Interpretation of the biological relevance of genotoxicity test results: the importance of thresholds (Q33816103)

29 July 2017

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title

Interpretation of the biological relevance of genotoxicity test results: the importance of thresholds (English)

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29 July 2017

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Kirkland DJ

1

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PubMed ID

10633186

29 July 2017

Müller L

series ordinal

2

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PubMed ID

10633186

29 July 2017

language of work or name

English

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publication date

1 January 2000

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29 July 2017

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29 July 2017

464

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29 July 2017

1

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29 July 2017

137-147

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The quality of genotoxicity testing of drugs. Experiences of a regulatory agency with new and old compounds

29 July 2017

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https://api.crossref.org/works/10.1016%2FS1383-5718%2899%2900175-8

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Human biological relevance and the use of threshold-arguments in regulatory genotoxicity assessment: experience with pharmaceuticals

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https://api.crossref.org/works/10.1016%2FS1383-5718%2899%2900175-8

7 January 2021

International Commission for Protection against Environmental Mutagens and Carcinogens. ICPEMC publication no. 10. Review of the evidence for the presence or absence of thresholds in the induction of genetic effects by genotoxic chemicals

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https://api.crossref.org/works/10.1016%2FS1383-5718%2899%2900175-8

7 January 2021

International Commission for Protection Against Environmental Mutagens and Carcinogens. Genotoxicity under extreme culture conditions. A report from ICPEMC Task Group 9.

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https://api.crossref.org/works/10.1016%2FS1383-5718%2899%2900175-8

7 January 2021

Chromosomal aberration tests in vitro: problems with protocol design and interpretation of results.

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Evaluation of the in vitro micronucleus test as an alternative to the in vitro chromosomal aberration assay: position of the GUM Working Group on the in vitro micronucleus test. Gesellschaft für Umwelt-Mutations-forschung

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https://api.crossref.org/works/10.1016%2FS1383-5718%2899%2900175-8

7 January 2021

Towards a validation of the micronucleus test

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Comparative evaluation of the in vitro micronucleus test and the in vitro chromosome aberration test: industrial experience

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https://api.crossref.org/works/10.1016%2FS1383-5718%2899%2900175-8

7 January 2021

Chromosomal aberrations in V79 hamster cells induced by hyperosmotic solutions of NaCl

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7 January 2021

Low pH leads to sister-chromatid exchanges and chromosomal aberrations, and its clastogenicity is S-dependent

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7 January 2021

Sodium azide mutagenesis in mammals: inability of mammalian cells to convert azide to a mutagenic intermediate.

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7 January 2021

Series: current issues in mutagenesis and carcinogenesis, No. 65. The genotoxicity and carcinogenicity of paracetamol: a regulatory (re)view

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7 January 2021

International Workshop on Standardisation of Genotoxicity Test Procedures. Report of the in vitro sub-group

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7 January 2021

Recommendations for spacing of test chemical concentrations in the mouse lymphoma tk mutation assay (MLA)

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7 January 2021

Discrimination between genotoxicity and cytotoxicity in the induction of DNA double-strand breaks in cells treated with etoposide, melphalan, cisplatin, potassium cyanide, Triton X-100, and gamma-irradiation

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DNA synthesis inhibition as an indirect mechanism of chromosome aberrations: comparison of DNA-reactive and non-DNA-reactive clastogens

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7 January 2021

Effects of high osmotic strength on chromosome aberrations, sister-chromatid exchanges and DNA strand breaks, and the relation to toxicity

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Rapid DNA degradation in primary rat hepatocytes treated with diverse cytotoxic chemicals: analysis by pulsed field gel electrophoresis and implications for alkaline elution assays.

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7 January 2021

10.1016/S1383-5718(99)00175-8

Identifiers

DOI

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29 July 2017

1 reference

PubMed ID

10633186