GITR ligand fusion protein agonist enhances the tumor antigen-specific CD8 T-cell response and leads to long-lasting memory. (Q33814776)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28649380%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

title

GITR ligand fusion protein agonist enhances the tumor antigen-specific CD8 T-cell response and leads to long-lasting memory (English)

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23 March 2020

1

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23 March 2020

author name string

Nick Holoweckyj

2

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23 March 2020

Randall S MacGill

3

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23 March 2020

Kelly McGlinchey

4

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23 March 2020

Ching Ching Leow

5

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23 March 2020

Scott H Robbins

6

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23 March 2020

publication date

20 June 2017

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Journal for Immunotherapy of Cancer

23 March 2020

published in

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23 March 2020

volume

5

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23 March 2020

page(s)

47

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https://scigraph.springernature.com/pub.10.1186/s40425-017-0247-0

23 March 2020

exact match

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cites work

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Authentic GITR Signaling Fails To Induce Tumor Regression unless Foxp3+ Regulatory T Cells Are Depleted

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IL-15-dependent upregulation of GITR on CD8 memory phenotype T cells in the bone marrow relative to spleen and lymph node suggests the bone marrow as a site of superior bioavailability of IL-15.

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Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation

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28 July 2018

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Agonist anti-GITR antibody enhances vaccine-induced CD8(+) T-cell responses and tumor immunity

28 July 2018

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Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells.

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Costimulation via glucocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells

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Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells

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A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis

28 July 2018

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Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen.

28 July 2018

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Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance

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A Novel Murine GITR Ligand Fusion Protein Induces Antitumor Activity as a Monotherapy That Is Further Enhanced in Combination with an OX40 Agonist

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Pivotal roles of CD4+ effector T cells in mediating agonistic anti-GITR mAb-induced-immune activation and tumor immunity in CT26 tumors

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CD8 T cell-intrinsic GITR is required for T cell clonal expansion and mouse survival following severe influenza infection

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10.1186/S40425-017-0247-0

Identifiers

DOI

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Dimensions Publication ID

23 March 2020

1 reference

https://scigraph.springernature.com/pub.10.1186/s40425-017-0247-0

9 September 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28649380%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

1 reference