Redox signalling and transition metals in the control of the p53 pathway (Q33800722)

29 July 2017

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title

Redox signalling and transition metals in the control of the p53 pathway (English)

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29 July 2017

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Méplan C

1

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29 July 2017

Richard MJ

series ordinal

2

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29 July 2017

Hainaut P

series ordinal

3

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29 July 2017

language of work or name

English

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publication date

1 January 2000

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29 July 2017

Biochemical Pharmacology

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29 July 2017

59

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29 July 2017

1

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29 July 2017

25-33

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Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

29 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Transcriptional activation of the human glutathione peroxidase promoter by p53.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Inhibition of cyclooxygenase-2 gene expression by p53.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

A model for p53-induced apoptosis

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Mutant conformation of p53. Precise epitope mapping using a filamentous phage epitope library

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Temperature sensitivity for conformation is an intrinsic property of wild-type p53.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Flexibility: the key to p53 function?

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Allosteric activation of latent p53 tetramers

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Tumor necrosis factor-induced apoptosis stimulates p53 accumulation and p21WAF1 proteolysis in ME-180 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

p53 protein expression is correlated with benzo[a]pyrene-DNA adducts in carcinoma cell lines

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Mdm2 promotes the rapid degradation of p53

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Regulation of p53 stability by Mdm2

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

DNA damage induces phosphorylation of the amino terminus of p53

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Radiation, DNA damage and cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

The DNA-dependent protein kinase

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Recruitment of p300/CBP in p53-dependent signal pathways

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Synergistic activation of transcription by CBP and p53

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Identification of redox/repair protein Ref-1 as a potent activator of p53

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

p53 inhibits hypoxia-inducible factor-stimulated transcription

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Characterization of baculovirus recombinant wild-type p53. Dimerization of p53 is required for high-affinity DNA binding and cysteine oxidation inhibits p53 DNA binding

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Divalent metal ions induce conformational change in pure, human wild-type p53 tumor suppressor protein

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Effect of transition metals on binding of p53 protein to supercoiled DNA and to consensus sequence in DNA fragments.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Activation of the cryptic DNA binding function of mutant forms of p53.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Role of cysteine residues in regulation of p53 function

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Modulation of p53 protein conformation and DNA-binding activity by intracellular chelation of zinc.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Pyrrolidine dithiocarbamate prevents p53 activation and promotes p53 cysteine residue oxidation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Regulation of p53 by metal ions and by antioxidants: dithiocarbamate down-regulates p53 DNA-binding activity by increasing the intracellular level of copper.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

1 Introduction to metallothionein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

A p53-independent Pathway for Activation of WAF1/CIP1 Expression Following Oxidative Stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Redox state regulates binding of p53 to sequence-specific DNA, but not to non-specific or mismatched DNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Redox gene therapy for ischemia/reperfusion injury of the liver reduces AP1 and NF-kappaB activation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Cooperation of protein disulfide isomerase and redox environment in the regulation of NF-kappaB and AP1 binding to DNA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

Cell cycle regulation of metallothionein in human colonic cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900297-X

10.1016/S0006-2952(99)00297-X

7 January 2021

Identifiers

DOI

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29 July 2017

1 reference