DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization (Q33773787)

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English	DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization	scientific article

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scholarly article

1 reference

Europe PubMed Central

29 July 2017

DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization (English)

1 reference

Europe PubMed Central

29 July 2017

1 reference

based on heuristic

inferred from title

bites and stings

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based on heuristic

inferred from title

author name string

Charlene M Downey

1

1 reference

Europe PubMed Central

29 July 2017

Mehrnoosh Aghaei

2

1 reference

Europe PubMed Central

29 July 2017

Reto A Schwendener

3

1 reference

Europe PubMed Central

29 July 2017

Frank R Jirik

4

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Europe PubMed Central

29 July 2017

language of work or name

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publication date

18 June 2014

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Europe PubMed Central

29 July 2017

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Europe PubMed Central

29 July 2017

9

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Europe PubMed Central

29 July 2017

6

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Europe PubMed Central

29 July 2017

e99988

1 reference

Europe PubMed Central

29 July 2017

copyright license

Creative Commons Attribution 4.0 International

18 June 2014

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April 2022 Public Data File from Crossref

copyright status

0 references

Rationale, progress and development of vaccines utilizing STING-activating cyclic dinucleotide adjuvants

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STING-dependent cytosolic DNA sensing pathways

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Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid

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28 July 2018

Identification of human-selective analogues of the vascular-disrupting agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)

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5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential

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STING is a direct innate immune sensor of cyclic di-GMP

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28 July 2018

Activation of mitogen-activated protein kinases by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) plays an important role in macrophage stimulation

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How genetically engineered mouse tumor models provide insights into human cancers

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Temporal aspects of the action of ASA404 (vadimezan; DMXAA).

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28 July 2018

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Acute vascular disruption by 5,6-dimethylxanthenone-4-acetic Acid in an orthotopic model of human head and neck cancer

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A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

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p38 mitogen-activated protein kinase is required for the antitumor activity of the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid.

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Identifiers

10.1371/JOURNAL.PONE.0099988

1 reference

Europe PubMed Central

29 July 2017

2014PLoSO...999988D

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1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

29 July 2017

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