Transcriptome analysis of recombinant protein secretion by Aspergillus nidulans and the unfolded-protein response in vivo (Q33769853)

29 July 2017

Transcriptome analysis of recombinant protein secretion by Aspergillus nidulans and the unfolded-protein response in vivo (English)

1 reference

Putative RAB family GTPase

29 July 2017

0 references

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Ortholog(s) have role in cellular response to biotic stimulus, cellular response to starvation and filamentous growth of a population of unicellular organisms in response to biotic stimulus, more

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Putative phosphotransferase with a predicted role in phospholipid metabolism

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Ortholog(s) have role in vesicle-mediated transport and cell division site, cell tip, cytosol, nucleus, prospore membrane localization

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Putative oligosaccharyltransferase beta subunit

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Putative 70 kilodalton heat shock protein

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Putative translocon, beta subunit

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Putative peptidyl-prolyl cis-trans isomerase D (PPIase)

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Peptidyl-prolyl cis-trans isomerase B, putative

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Putative nuclear pore complex protein with homology to Saccharomyces cerevisiae Sec13p

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Putative peptidyl-prolyl cis-trans isomerase (PPIase)

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Putative signal recognition particle protein

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Putative ubiquitin-conjugating enzyme

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Ortholog(s) have HDEL sequence binding activity, role in ER to Golgi vesicle-mediated transport, protein retention in ER lumen and Golgi apparatus, integral component of endoplasmic reticulum membrane localization

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Putative GTPase with a predicted role in transport between cis and medial Golgi compartments

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Putative oligosaccharyltransferase epsilon subunit

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Putative regulator of mannosylphosphorylation

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FKBP-type peptidyl-prolyl cis-trans isomerase

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Putative GTPase required for early endosome trafficking

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3-hydroxy-3-methylglutaryl-CoA reductase, putative

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Putative peptidyl-prolyl cis-trans isomerase (PPIase)

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Response regulator, part of a two-component signal transduction system involved in control of stress response and conidiation

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Putative peptidyl-prolyl cis-trans isomerase

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putative calnexin

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Putative pyrroline-5-carboxylate reductase with a predicted role in proline metabolism

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Putative Rab-like GTPase

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Putative protein disulfide isomerase

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Putative calcium-transporting ATPase with a predicted role in energy metabolism

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Putative GTPase with a role in retrograde traffic from endosomes to the Golgi

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Ortholog of A. fumigatus Af293 : Afu5g06970, A. niger CBS 513.88 : An17g00170, A. oryzae RIB40 : AO090701000290, Aspergillus versicolor : Aspve1_0135244 and Aspergillus clavatus NRRL 1 : ACLA_010110

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Ortholog(s) have cytosol, nucleus localization

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Putative myo-inositol-1-phosphate synthase with a predicted role in phospholipid metabolism

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Protein associated with the nonclassical protein export pathway

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Putative translocon, alpha subunit

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Ortholog(s) have phosphatidylinositol-3-phosphate binding activity, role in CVT pathway, early endosome to Golgi transport, mitophagy and cytosol, endosome, extrinsic component of membrane, pre-autophagosomal structure localization

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Putative ER protein-translocation complex subunit

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Essential phospho-Ser/Thr-directed peptidyl prolyl-isomerase involved in cell cycle progression

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1-acylglycerol-3-phosphate O-acyltransferase, putative

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dicarboxylic amino acid permease

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Putative 60 kilodalton heat shock protein

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Hsp70-family protein

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Ortholog(s) have ubiquitin binding activity

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Putative Rab GDP-dissociation inhibitor

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Putative Sec1p-like protein with a predicted role in vacuolar protein sorting

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TRAPP II complex subunit Trs120

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Ortholog(s) have GTP binding, signal recognition particle binding activity, role in protein targeting to ER and cytosol, nucleus, signal recognition particle receptor complex localization

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Putative ADP ribosylation factor guanine nucleotide exchange factor

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Putative mannosyltransferase

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Transcriptional activator hacA, putative

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Ortholog(s) have cytosol, plasma membrane localization

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ADP-ribosylation factor, putative

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Protein that plays a role in sensitivity to DNA-damaging agents

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Ortholog(s) have endoplasmic reticulum localization

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Ortholog of A. fumigatus Af293 : Afu1g15110, A. niger CBS 513.88 : An01g13270, A. oryzae RIB40 : AO090005001214, Neosartorya fischeri NRRL 181 : NFIA_010310 and Aspergillus wentii : Aspwe1_0051140

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Putative chaperone of the endoplasmic reticulum (ER) lumen

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Putative ER protein-translocation complex subunit

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Protein with a predicted role in ER-associated protein degradation

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Ortholog(s) have 7S RNA binding activity and role in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition, SRP-dependent cotranslational protein targeting to membrane, translocation

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Putative protein translocation complex subunit

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L-amino acid oxidase

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Putative GTPase with a predicted role in intra-Golgi transport

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Putative protein disulfide isomerase

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Putative phosphatidylinositol transfer protein

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Sensor for unfolded proteins in the ER ire1, putative

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Putative small GTPase involved in endosomal maturation and vacuolar biogenesis

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Putative protein disulfide isomerase

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Putative protein transport protein

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Putative heat shock protein

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Ortholog(s) have protein transporter activity, role in filamentous growth, posttranslational protein targeting to membrane, translocation and Sec62/Sec63 complex localization

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Putative zinc-finger protein with a predicted role in ER unfolded protein degradation

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Putative oligosaccharyltransferase delta subunit

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Putative phytase with a predicted role in phytic acid catabolism

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Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases (aspartate and proline transporters) into COPII coated vesicles for transport to the cell surface

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Putative mannose-1-phosphate guanyltransferase

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Putative ER-resident chaperone of the HSP70 family

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Putative ubiquitin-specific protease

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Putative ubiquitin-activating enzyme

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HOPS/CORVET complex subunit, vacuolar sorting protein, putative

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Similar to syntaxin proteins

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Putative P-type ATPase

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Putative signal sequence processing protein with a predicted role in targeting proteins to the endoplasmic reticulum

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Transcript levels increase during the unfolded-protein response (UPR)

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Putative secretory component

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Ortholog(s) have ATP binding, ATPase activity, protein homodimerization activity

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Putative 26S proteasome regulatory subunit

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FKBP-type peptidyl-prolyl cis-trans isomerase, putative

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Putative GTPase with a predicted role in ER to Golgi transport

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70 kilodalton heat shock protein

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Putative 30 kilodalton heat shock protein

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Protein with a predicted role in asparagine-linked glycosylation

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Putative ubiquitin-conjugating enzyme

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Protein involved in DNA repair

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Aspergillus nidulans

object named as

Aspergillus nidulans

1 reference

Andrew H Sims

1

0 references

author name string

Manda E Gent

2

1 reference

29 July 2017

Karin Lanthaler

3

1 reference

29 July 2017

Nigel S Dunn-Coleman

4

1 reference

29 July 2017

Stephen G Oliver

5

1 reference

29 July 2017

Geoffrey D Robson

6

1 reference

29 July 2017

language of work or name

English

0 references

publication date

1 May 2005

1 reference

Applied and Environmental Microbiology

29 July 2017

1 reference

29 July 2017

71

1 reference

29 July 2017

5

1 reference

29 July 2017

2737-2747

1 reference

Glutamic protease distribution is limited to filamentous fungi

29 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Combining transcriptome data with genomic and cDNA sequence alignments to make confident functional assignments for Aspergillus nidulans genes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Negative subtraction hybridization: an efficient method to isolate large numbers of condition-specific cDNAs

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Global analysis of nutrient control of gene expression in Saccharomyces cerevisiae during growth and starvation.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Characterization of the protein processing and secretion pathways in a comprehensive set of expressed sequence tags from Trichoderma reesei

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Use of expressed sequence tag analysis and cDNA microarrays of the filamentous fungus Aspergillus nidulans

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

The transcription factor HACA mediates the unfolded protein response in Aspergillus niger, and up-regulates its own transcription

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Role of the unfolded protein response pathway in regulation of INO1 and in the sec14 bypass mechanism in Saccharomyces cerevisiae.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Filamentous fungi as cell factories for heterologous protein production

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

The secretion pathway in filamentous fungi: a biotechnological view

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Small GTP-binding proteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Genomic expression programs in the response of yeast cells to environmental changes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Filamentous fungi as microbial cell factories for food use.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

A concise guide to cDNA microarray analysis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Molecular characterization of a PDI-related gene prpA in Aspergillus niger var. awamori

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Protein targeting to the endoplasmic reticulum in yeast. 1997 Fleming Lecture

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Vesicular transport: how many Ypt/Rab-GTPases make a eukaryotic cell?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

The ER chaperone encoding bipA gene of black Aspergilli is induced by heat shock and unfolded proteins.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Molecular evidence for an ancient duplication of the entire yeast genome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Efficient production of secreted proteins by Aspergillus: progress, limitations and prospects

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Overexpression of binding protein and disruption of the PMR1 gene synergistically stimulate secretion of bovine prochymosin but not plant thaumatin in yeast.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

From DNA sequence to biological function

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Protein disulfide isomerase mutant lacking its isomerase activity accelerates protein folding in the cell.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Synthesis of calf prochymosin (prorennin) in Escherichia coli

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

A GTP-binding protein required for secretion rapidly associates with secretory vesicles and the plasma membrane in yeast

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Production of extracellular proteins by the filamentous fungus Aspergillus

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Commercial levels of chymosin production by Aspergillus

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Identification of a novel gene hbrB required for polarised growth in Aspergillus nidulans

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Improvement of foreign-protein production in Aspergillus niger var. awamori by constitutive induction of the unfolded-protein response

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

The effects of drugs inhibiting protein secretion in the filamentous fungus Trichoderma reesei. Evidence for down-regulation of genes that encode secreted proteins in the stressed cells

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Activation mechanisms of the HAC1-mediated unfolded protein response in filamentous fungi

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Genomic analysis of the unfolded protein response in Arabidopsis shows its connection to important cellular processes

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Mcm1p-induced DNA bending regulates the formation of ternary transcription factor complexes.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

The foldase CYPB is a component of the secretory pathway of Aspergillus niger and contains the endoplasmic reticulum retention signal HEEL.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Production of tissue plasminogen activator (t-PA) in Aspergillus niger

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Identification and characterization of a family of secretion-related small GTPase-encoding genes from the filamentous fungus Aspergillus niger: a putative SEC4 homologue is not essential for growth

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Glucoamylase::green fluorescent protein fusions to monitor protein secretion in Aspergillus niger

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Molecular cloning and characterization of Aspergillus nidulans cyclophilin B.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Isolation and characterisation of a gene encoding protein disulphide isomerase, pdiA, from Aspergillus niger.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Nucleotide sequence of the Aspergillus niger srpA gene

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Use of Aspergillus overproducing mutants, cured for integrated plasmid, to overproduce heterologous proteins

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Expression of calf prochymosin in Saccharomyces cerevisiae

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087583

Expression of cloned calf prochymosin gene sequence in Escherichia coli

30 October 2018

1 reference

12 December 2020

Efficient synthesis of enzymatically active calf chymosin in Saccharomyces cerevisiae

1 reference

12 December 2020

Improved production of chymosin in Aspergillus by expression as a glucoamylase-chymosin fusion

1 reference

12 December 2020

Secretion of calf chymosin from the filamentous fungus Aspergillus oryzae

1 reference

12 December 2020

Degradation of proteins from the ER of S. cerevisiae requires an intact unfolded protein response pathway

1 reference

12 December 2020

A glucoamylase::GFP gene fusion to study protein secretion by individual hyphae of Aspergillus niger

1 reference

12 December 2020

Functional implications of disulfide bond, Cys206-Cys210, in recombinant prochymosin (chymosin)

1 reference

12 December 2020

A defined level of protein disulfide isomerase expression is required for optimal secretion of thaumatin by Aspegillus awamori

1 reference

12 December 2020

Hybridization array technology coupled with chemostat culture: Tools to interrogate gene expression in Saccharomyces cerevisiae

1 reference

12 December 2020

Isolation and characterisation of a calnexin homologue, clxA, from Aspergillus niger

1 reference

12 December 2020

Analysis of the role of the gene bipA, encoding the major endoplasmic reticulum chaperone protein in the secretion of homologous and heterologous proteins in black Aspergilli

1 reference

12 December 2020

10.1128/AEM.71.5.2737-2747.2005

Identifiers

DOI

1 reference

29 July 2017

1 reference

29 July 2017

1 reference