PTEN gene and integrin signaling in cancer (Q33765703)

29 July 2017

title

PTEN gene and integrin signaling in cancer (English)

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29 July 2017

M Tamura

1

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29 July 2017

J Gu

series ordinal

2

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29 July 2017

H Tran

series ordinal

3

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29 July 2017

K M Yamada

series ordinal

4

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29 July 2017

publication date

1 November 1999

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Journal of the National Cancer Institute

29 July 2017

language of work or name

English

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published in

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29 July 2017

volume

91

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29 July 2017

issue

21

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29 July 2017

page(s)

1820-1828

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publication type of scholarly work

29 July 2017

review article

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Molecular themes in oncogenesis

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

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P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

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A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

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Presence of an SH2 Domain in the Actin-Binding Protein Tensin

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Pten is essential for embryonic development and tumour suppression

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

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Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

21 January 2018

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Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

21 January 2018

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Germline mutations in PTEN are present in Bannayan-Zonana syndrome

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PTEN mutations in gliomas and glioneuronal tumors.

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Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers

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PTEN (MMAC1) Mutations Are Frequent in Primary Glioblastomas (de novo) but not in Secondary Glioblastomas

21 January 2018

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Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

21 January 2018

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Phosphatases and tumorigenesis

21 January 2018

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Integrin function: molecular hierarchies of cytoskeletal and signaling molecules

21 January 2018

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Molecular interactions in cell adhesion complexes

21 January 2018

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Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function

21 January 2018

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Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

21 January 2018

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An interaction between alpha-actinin and the beta 1 integrin subunit in vitro

21 January 2018

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Sequence and domain structure of talin

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Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly

21 January 2018

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Integrin-mediated cell adhesion promotes tyrosine phosphorylation of p130Cas, a Src homology 3-containing molecule having multiple Src homology 2-binding motifs

21 January 2018

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Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases

21 January 2018

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Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors

21 January 2018

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alpha vbeta 3 integrin associates with activated insulin and PDGFbeta receptors and potentiates the biological activity of PDGF

21 January 2018

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Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex

21 January 2018

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Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

21 January 2018

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Induction of carcinoma cell migration on vitronectin by NF-kappa B-dependent gene expression.

21 January 2018

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Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase

21 January 2018

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21 January 2018

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A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth

21 January 2018

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A role for Jun-N-terminal kinase in anoikis; suppression by bcl-2 and crmA.

21 January 2018

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Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown

21 January 2018

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Growth factor activation of MAP kinase requires cell adhesion.

21 January 2018

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Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information

21 January 2018

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21 January 2018

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Integrins take partners: cross-talk between integrins and other membrane receptors

21 January 2018

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Integrins and GTPases in tumour cell growth, motility and invasion

21 January 2018

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The biology of cancer metastasis or, ‘you cannot fix it if you do not know how it works’

21 January 2018

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Adhesion molecules and tumor cell interaction with endothelium and subendothelial matrix

21 January 2018

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21 January 2018

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Cell surface interactions with extracellular materials

21 January 2018

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Elevated levels of the alpha 5 beta 1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells

21 January 2018

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Integrin alpha 5 beta 1 expression negatively regulates cell growth: reversal by attachment to fibronectin

21 January 2018

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Integrin-dependent signal transduction

21 January 2018

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Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction

21 January 2018

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A link between cyclin A expression and adhesion-dependent cell cycle progression

21 January 2018

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Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

Regulation of the cell cycle by focal adhesion kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

Control of adhesion-dependent cell survival by focal adhesion kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

The adaptor protein Shc couples a class of integrins to the control of cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

Inhibition of pp125FAK in cultured fibroblasts results in apoptosis

21 January 2018

1 reference

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Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I.

21 January 2018

1 reference

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Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

21 January 2018

1 reference

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Phosphatidylinositol 3-Kinase Is Required for Integrin-Stimulated AKT and Raf-1/Mitogen-Activated Protein Kinase Pathway Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

Integrin signalling and tyrosine phosphorylation: just the FAKs?

21 January 2018

1 reference

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Focal adhesion kinase in integrin signaling

21 January 2018

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Signaling through focal adhesion kinase

21 January 2018

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Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase

21 January 2018

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Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins

21 January 2018

1 reference

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Integrin-mediated activation of MAP kinase is independent of FAK: evidence for dual integrin signaling pathways in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

Direct Association of Protein-tyrosine Phosphatase PTP-PEST with Paxillin

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

Protein-tyrosine phosphatase alpha regulates Src family kinases and alters cell-substratum adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

Protein tyrosine phosphatase 1B negatively regulates integrin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

The nonreceptor protein tyrosine phosphatase PTP1B binds to the cytoplasmic domain of N-cadherin and regulates the cadherin-actin linkage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

Impaired integrin-mediated adhesion and signaling in fibroblasts expressing a dominant-negative mutant PTP1B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells

21 January 2018

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Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

21 January 2018

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A mechanism for regulation of the adhesion-associated proteintyrosine kinase pp125FAK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

Regulation of chemotaxis by the platelet-derived growth factor receptor-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

p130Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

Identification of p130Cas as a Mediator of Focal Adhesion Kinase–promoted Cell Migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

CAS/Crk Coupling Serves as a “Molecular Switch” for Induction of Cell Migration

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

Shc and FAK differentially regulate cell motility and directionality modulated by PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

Regulation of cell motility by mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

Mechanisms and consequences of activation of protein kinase B/Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

Specific TrkA survival signals interfere with different apoptotic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

Induction of apoptosis after expression of PYK2, a tyrosine kinase structurally related to focal adhesion kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.21.1820

21 January 2018

Identifiers

DOI

10.1093/JNCI/91.21.1820

1 reference

29 July 2017

1 reference