The formulated microbicide RC-101 was safe and antivirally active following intravaginal application in pigtailed macaques (Q33760642)

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17 January 2020

title

The formulated microbicide RC-101 was safe and antivirally active following intravaginal application in pigtailed macaques (English)

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17 January 2020

12

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17 January 2020

13

Robert I Lehrer

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17 January 2020

author name string

Alexander M Cole

1

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17 January 2020

Dorothy L Patton

2

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17 January 2020

Lisa C Rohan

3

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17 January 2020

Amy L Cole

4

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17 January 2020

Yvonne Cosgrove-Sweeney

5

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17 January 2020

Nicole A Rogers

6

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17 January 2020

Deena Ratner

7

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17 January 2020

Alexandra B Sassi

8

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17 January 2020

Carol Lackman-Smith

9

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17 January 2020

Patrick Tarwater

10

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17 January 2020

Bharat Ramratnam

11

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17 January 2020

Alan J Waring

14

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17 January 2020

Phalguni Gupta

15

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17 January 2020

language of work or name

English

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publication date

29 November 2010

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17 January 2020

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17 January 2020

volume

5

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17 January 2020

issue

11

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17 January 2020

page(s)

e15111

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Creative Commons Attribution 4.0 International

17 January 2020

copyright license

start time

29 November 2010

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Formulation development of retrocyclin 1 analog RC-101 as an anti-HIV vaginal microbicide product

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993972

Identification of gammaretroviruses constitutively released from cell lines used for human immunodeficiency virus research

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993972

A summary of preclinical topical microbicide vaginal safety and chlamydial efficacy evaluations in a pigtailed macaque model

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993972

Retrocyclin RC-101 overcomes cationic mutations on the heptad repeat 2 region of HIV-1 gp41.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993972

HIV-1 adapts to a retrocyclin with cationic amino acid substitutions that reduce fusion efficiency of gp41.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993972

The θ-Defensin, Retrocyclin, Inhibits HIV-1 Entry

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993972

Relationship of vaginal bacteria and inflammation with conception and early pregnancy loss following in-vitro fertilization

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993972

Retrocyclin: a primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993972

Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp120

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993972

A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993972

0.25% chlorhexidine gluconate gel. A protective topical microbicide

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993972

Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993972

The vaginal microflora of pig-tailed macaques and the effects of chlorhexidine and benzalkonium on this ecosystem.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993972

Effects of nonoxynol-9 on vaginal microflora and chlamydial infection in a monkey model

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993972

The role of mononuclear phagocytes in HTLV-III/LAV infection

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993972

Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda

28 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015111

Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015111

Evolution of primate theta-defensins: a serpentine path to a sweet tooth

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015111

The retrocyclin analogue RC-101 prevents human immunodeficiency virus type 1 infection of a model human cervicovaginal tissue construct

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015111

RC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015111

A theta-defensin composed exclusively of D-amino acids is active against HIV-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015111

The normal vaginal flora, H2O2-producing lactobacilli, and bacterial vaginosis in pregnant women.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015111

Effects of multiple applications of benzalkonium chloride and nonoxynol 9 on the vaginal epithelium in the pigtailed macaque (Macaca nemestrina).

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015111

Safety and efficacy evaluations for vaginal and rectal use of BufferGel in the macaque model

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015111

Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015111

Growth of macrophage-tropic and primary human immunodeficiency virus type 1 (HIV-1) isolates in a unique CD4+ T-cell clone (PM1): failure to downregulate CD4 and to interfere with cell-line-tropic HIV-1.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993972

θ-Defensins Prevent HIV-1 Env-mediated Fusion by Binding gp41 and Blocking 6-Helix Bundle Formation

30 October 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015111

Vaginal myeloperoxidase and flora in the pig-tailed macaque

21 January 2018

1 reference

12 December 2020

Lactobacillus crispatus capsules: single-use safety study in the Macaca nemestrina model

1 reference

12 December 2020

Macaca fascicularis vs. Macaca nemestrina as a model for topical microbicide safety studies

1 reference

12 December 2020

HBTU activation for automated Fmoc solid-phase peptide synthesis

1 reference

12 December 2020

The vaginal microbial ecosystem and resistance to HIV

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0015111

Identifiers

DOI

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17 January 2020

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1 reference

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17 January 2020

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