Suboptimal Dosing Parameters as Possible Factors in the Negative Phase III Clinical Trials of Progesterone for Traumatic Brain Injury (Q33756256)

29 July 2017

5 references

25 April 2019

19 June 2019

19 September 2019

13 November 2019

17 November 2019

Suboptimal Dosing Parameters as Possible Factors in the Negative Phase III Clinical Trials of Progesterone for Traumatic Brain Injury (English)

1 reference

biomedical investigative technique

29 July 2017

phase III clinical trial

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traumatic brain injury

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1 reference

19 September 2019

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13 November 2019

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17 November 2019

Randy B Howard

1

1 reference

29 July 2017

Iqbal Sayeed

series ordinal

2

1 reference

29 July 2017

Donald G Stein

series ordinal

3

1 reference

29 July 2017

language of work or name

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15 September 2015

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29 July 2017

1 June 2017

5 references

25 April 2019

19 June 2019

19 September 2019

13 November 2019

17 November 2019

Journal of Neurotrauma

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29 July 2017

25 April 2019

19 June 2019

19 September 2019

13 November 2019

17 November 2019

34

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29 July 2017

11

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29 July 2017

1915-1918

1 reference

Creative Commons Attribution-NonCommercial

29 July 2017

5 references

25 April 2019

19 June 2019

19 September 2019

13 November 2019

17 November 2019

on focus list of Wikimedia project

ScienceSource

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cites work

Embracing failure: What the Phase III progesterone studies can teach about TBI clinical trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455214

Bench-to-Bedside and Bedside Back to the Bench; Seeking a Better Understanding of the Acute Pathophysiological Process in Severe Traumatic Brain Injury

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455214

A clinical trial of progesterone for severe traumatic brain injury

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455214

Very early administration of progesterone for acute traumatic brain injury.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455214

Cerebrolysin Asian Pacific trial in acute brain injury and neurorecovery: design and methods

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455214

Progesterone in transient ischemic stroke: a dose-response study

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455214

Progesterone in experimental permanent stroke: a dose-response and therapeutic time-window study

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455214

The neuroprotective effects of progesterone on traumatic brain injury: current status and future prospects

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455214

Of Timescales, Animal Models, and Human Disease: The 50th Anniversary of C. elegans as a Biological Model

21 June 2018

1 reference

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The Laboratory Rat: Relating Its Age With Human's

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455214

A clinical/translational perspective: can a developmental hormone play a role in the treatment of traumatic brain injury?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455214

Progesterone synthesis in the nervous system: implications for myelination and myelin repair.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455214

Re-orientation of clinical research in traumatic brain injury: report of an international workshop on comparative effectiveness research

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455214

Potential relevance of bell-shaped and u-shaped dose-responses for the therapeutic targeting of angiogenesis in cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455214

Progesterone as a neuroprotective factor in traumatic and ischemic brain injury

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455214

To scale or not to scale: the principles of dose extrapolation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455214

Progesterone neuroprotection in traumatic CNS injury and motoneuron degeneration.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455214

Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455214

ProTECT: a randomized clinical trial of progesterone for acute traumatic brain injury

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455214

Steady-state serum concentrations of progesterone following continuous intravenous infusion in patients with acute moderate to severe traumatic brain injury

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455214

Behavioral effects and anatomic correlates after brain injury: a progesterone dose–response study

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455214

Effects of the duration of progesterone treatment on the resolution of cerebral edema induced by cortical contusions in rats.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455214

Progesterone exacerbates striatal stroke injury in progesterone-deficient female animals

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455214

Progesterone for traumatic brain injury--resisting the sirens' song.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455214

Progesterone pharmacokinetics in the mouse: implications for potential stroke therapy.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455214

Getting neurorehabilitation right: what can be learned from animal models?

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455214

Superoxide dismutase, lipid peroxidation, and bell-shaped dose response curves

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455214

Progesterone protects against necrotic damage and behavioral abnormalities caused by traumatic brain injury

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455214

Serum progesterone levels correlate with decreased cerebral edema after traumatic brain injury in male rats

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5455214

Comparing rat's to human's age: how old is my rat in people years?

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26370183

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1089/NEU.2015.4179

1 reference

29 July 2017

1 reference

29 July 2017

1 reference