Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations (Q33742421)

29 July 2017

Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations (English)

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Tora K Smulders-Srinivasan

29 July 2017

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Tora K Smulders-Srinivasan

2

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Andrey Y. Abramov

Andrey Y Abramov

1

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Michael R. Duchen

Michael R Duchen

Douglass Matthew Turnbull

7

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8

Douglass M Turnbull

1 reference

29 July 2017

Denise M Kirby

3

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29 July 2017

Rebeca Acin-Perez

4

1 reference

29 July 2017

José Antonio Enriquez

5

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29 July 2017

Robert N Lightowlers

6

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29 July 2017

language of work or name

English

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publication date

15 February 2010

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29 July 2017

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29 July 2017

133

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29 July 2017

Pt 3

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29 July 2017

797-807

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describes a project that uses

29 July 2017

1 reference

Transmitochondrial embryonic stem cells containing pathogenic mtDNA mutations are compromised in neuronal differentiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

Mouse models of mitochondrial DNA defects and their relevance for human disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

Pathogenic mitochondrial DNA mutations are common in the general population

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

The mitochondrial impairment, oxidative stress and neurodegeneration connection: reality or just an attractive hypothesis?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

Strong purifying selection in transmission of mammalian mitochondrial DNA

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

Mitochondrial ND5 gene variation associated with encephalomyopathy and mitochondrial ATP consumption

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

Prevalence of mitochondrial DNA disease in adults

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

Mitochondrial disease--its impact, etiology, and pathology.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

Mitochondrial DNA mutations in human disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

Neuropathological aspects of mitochondrial DNA disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

Glutathione pathways in the brain.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

Differentiation-specific effects of LHON mutations introduced into neuronal NT2 cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

Mitochondria and calcium: from cell signalling to cell death

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

Mitochondria exert a negative feedback on the propagation of intracellular Ca2+ waves in rat cortical astrocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

Mitochondria buffer physiological calcium loads in cultured rat dorsal root ganglion neurons.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

Neuropathology in Kearns-Sayre syndrome

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

The Cycling of Calcium, Sodium, and Protons Across the Inner Membrane of Cardiac Mitochondria

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

Prevalence of mitochondrial 1555A-->G mutation in adults of European descent.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

Dopaminergic midbrain neurons are the prime target for mitochondrial DNA deletions

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

Molecular neuropathology of MELAS: level of heteroplasmy in individual neurones and evidence of extensive vascular involvement.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

Acute glutathione depletion restricts mitochondrial ATP export in cerebellar granule neurons.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

MELAS: clinical phenotype and morphological brain abnormalities

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

Imaging mitochondrial function in intact cells.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

Quantitative imaging of glutathione in hippocampal neurons and glia in culture using monochlorobimane

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842515

Generation of mice with mitochondrial dysfunction by introducing mouse mtDNA carrying a deletion into zygotes

30 October 2018

1 reference

12 December 2020

Relative levels of hexokinase in isolated neuronal, astrocytic, and oligodendroglial fractions from rat brain

1 reference

12 December 2020

Ca ion uptake by rat kidney mitochondria and its dependence on respiration and phosphorylation

1 reference

12 December 2020

CATION AND ANION BALANCE DURING ACTIVE ACCUMULATION OF CA++ AND MG++ BY ISOLATED MITOCHONDRIA

1 reference

12 December 2020

Prevalence of Mitochondrial 1555A→G Mutation in European Children

1 reference

12 December 2020

Identifiers

DOI

10.1093/BRAIN/AWQ015

1 reference

29 July 2017

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29 July 2017

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