Inhibition of the ribonuclease H activity of HIV-1 reverse transcriptase by GSK5750 correlates with slow enzyme-inhibitor dissociation (Q33718515)

28 July 2017

title

Inhibition of the ribonuclease H activity of HIV-1 reverse transcriptase by GSK5750 correlates with slow enzyme-inhibitor dissociation (English)

1 reference

28 July 2017

Greg L Beilhartz

1

1 reference

28 July 2017

Marianne Ngure

2

1 reference

28 July 2017

Brian A Johns

3

1 reference

28 July 2017

Felix DeAnda

4

1 reference

28 July 2017

Peter Gerondelis

5

1 reference

28 July 2017

Matthias Götte

6

1 reference

28 July 2017

language of work or name

English

0 references

publication date

9 April 2014

1 reference

Journal of Biological Chemistry

28 July 2017

published in

1 reference

28 July 2017

volume

289

1 reference

28 July 2017

issue

23

1 reference

28 July 2017

page(s)

16270-16277

1 reference

HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors

28 July 2017

cites work

1 reference

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21 June 2018

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Structural Basis for the Inhibition of RNase H Activity of HIV-1 Reverse Transcriptase by RNase H Active Site-Directed Inhibitors

21 June 2018

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Structure of HIV-1 Reverse Transcriptase with the Inhibitor β-Thujaplicinol Bound at the RNase H Active Site

21 June 2018

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21 June 2018

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HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition

21 June 2018

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Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity

21 June 2018

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21 June 2018

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21 June 2018

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HIV-1 Reverse Transcriptase Structure with RNase H Inhibitor Dihydroxy Benzoyl Naphthyl Hydrazone Bound at a Novel Site

21 June 2018

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21 June 2018

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Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA

21 June 2018

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Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

21 June 2018

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Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA

21 June 2018

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HIV-1 reverse transcriptase-associated RNase H cleaves RNA/RNA in arrested complexes: implications for the mechanism by which RNase H discriminates between RNA/RNA and RNA/DNA

21 June 2018

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Nevirapine alters the cleavage specificity of ribonuclease H of human immunodeficiency virus 1 reverse transcriptase

21 June 2018

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Use of an oligoribonucleotide containing the polypurine tract sequence as a primer by HIV reverse transcriptase

21 June 2018

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21 June 2018

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Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase

21 June 2018

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Reverse transcriptase.RNase H from the human immunodeficiency virus. Relationship of the DNA polymerase and RNA hydrolysis activities

21 June 2018

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Processing of the primer for plus strand DNA synthesis by human immunodeficiency virus 1 reverse transcriptase

21 June 2018

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Specificity of human immunodeficiency virus-1 reverse transcriptase-associated ribonuclease H in removal of the minus-strand primer, tRNA(Lys3)

21 June 2018

1 reference

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Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor

21 June 2018

1 reference

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Mechanism and fidelity of HIV reverse transcriptase

21 June 2018

1 reference

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Human immunodeficiency virus type 1 reverse transcriptase: spatial and temporal relationship between the polymerase and RNase H activities

21 June 2018

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Site-specific footprinting reveals differences in the translocation status of HIV-1 reverse transcriptase. Implications for polymerase translocation and drug resistance

21 June 2018

1 reference

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Mutational analysis of Tyr-501 of HIV-1 reverse transcriptase. Effects on ribonuclease H activity and inhibition of this activity by N-acylhydrazones

21 January 2018

1 reference

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Transient kinetic analyses of the ribonuclease H cleavage activity of HIV-1 reverse transcriptase in complex with efavirenz and/or a β-thujaplicinol analogue

21 January 2018

1 reference

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Rapid purification of homodimer and heterodimer HIV-1 reverse transcriptase by metal chelate affinity chromatography.

21 January 2018

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Temporal coordination between initiation of HIV (+)-strand DNA synthesis and primer removal

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24719329

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M114.569707

1 reference

release_brexwsusyvd33lrpe46weogulq

28 July 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/brexwsusyvd33lrpe46weogulq

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

4047396

1 reference

28 July 2017

1 reference