The effect of protein kinase C and G protein-coupled receptor kinase inhibition on tolerance induced by mu-opioid agonists of different efficacy (Q33714922)

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English	The effect of protein kinase C and G protein-coupled receptor kinase inhibition on tolerance induced by mu-opioid agonists of different efficacy	scientific article

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15 January 2020

The effect of protein kinase C and G protein-coupled receptor kinase inhibition on tolerance induced by mu-opioid agonists of different efficacy (English)

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15 January 2020

G protein-coupled receptor

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6

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15 January 2020

author name string

L C Hull

1

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15 January 2020

J Llorente

2

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15 January 2020

B H Gabra

3

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15 January 2020

F L Smith

4

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15 January 2020

E Kelly

5

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15 January 2020

G Henderson

7

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15 January 2020

W L Dewey

8

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publication date

14 December 2009

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15 January 2020

Journal of Pharmacology and Experimental Therapeutics

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15 January 2020

332

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15 January 2020

3

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15 January 2020

1127-1135

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15 January 2020

Involvement of PKC alpha and G-protein-coupled receptor kinase 2 in agonist-selective desensitization of mu-opioid receptors in mature brain neurons.

1 reference

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21 June 2018

Agonist-selective mechanisms of GPCR desensitization

1 reference

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21 June 2018

GPCR functional selectivity has therapeutic impact

1 reference

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21 June 2018

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

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21 June 2018

Agonist-selective mechanisms of mu-opioid receptor desensitization in human embryonic kidney 293 cells

1 reference

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21 June 2018

Differential activation of G-proteins by mu-opioid receptor agonists

1 reference

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The role of opioid receptor internalization and beta-arrestins in the development of opioid tolerance

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G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal

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SOME NARCOTIC ANTAGONISTS IN THE BENZOMORPHAN SERIES

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21 June 2018

Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence

1 reference

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Involvement of G protein-coupled receptor kinase-6 in desensitization of CGRP receptors

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Spinal PKC activity and expression: role in tolerance produced by continuous spinal morphine infusion

1 reference

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Ligand-induced changes in surface mu-opioid receptor number: relationship to G protein activation?

1 reference

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Involvement of intracellular calcium in morphine tolerance in mice

1 reference

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21 June 2018

Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness

1 reference

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Signal transduction correlates of mu opioid agonist intrinsic efficacy: receptor-stimulated [35S]GTP gamma S binding in mMOR-CHO cells and rat thalamus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835442

21 June 2018

mu-Opioid receptor internalization: opiate drugs have differential effects on a conserved endocytic mechanism in vitro and in the mammalian brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835442

21 June 2018

Down-regulation of mu-opioid receptor by full but not partial agonists is independent of G protein coupling

1 reference

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21 June 2018

mu-Opioid receptor-stimulated guanosine-5'-O-(gamma-thio)-triphosphate binding in rat thalamus and cultured cell lines: signal transduction mechanisms underlying agonist efficacy

1 reference

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21 June 2018

Morphine activates opioid receptors without causing their rapid internalization

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21 June 2018

Phosphorylation and agonist-specific intracellular trafficking of an epitope-tagged mu-opioid receptor expressed in HEK 293 cells

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Determination and characterization of the antinociceptive activity of intraventricularly administered acetylcholine in mice

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21 June 2018

Dosing protocol and analgesic efficacy determine opioid tolerance in the mouse

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30 October 2018

PKC and PKA inhibitors reinstate morphine-induced behaviors in morphine tolerant mice

1 reference

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30 October 2018

How important is protein kinase C in mu-opioid receptor desensitization and morphine tolerance?

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Protein kinase C activation enhances morphine-induced rapid desensitization of mu-opioid receptors in mature rat locus ceruleus neurons

1 reference

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Mu-opioid receptor desensitization in mature rat neurons: lack of interaction between DAMGO and morphine.

1 reference

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The expression of a high level of morphine antinociceptive tolerance in mice involves both PKC and PKA.

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Prolonged reversal of morphine tolerance with no reversal of dependence by protein kinase C inhibitors

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Rational design and evaluation of new lead compound structures for selective betaARK1 inhibitors

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1 reference

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12 December 2020

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10.1124/JPET.109.161455

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15 January 2020

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15 January 2020

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15 January 2020

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