Agonist-dependent mu-opioid receptor signaling can lead to heterologous desensitization (Q33708526)

28 July 2017

Agonist-dependent mu-opioid receptor signaling can lead to heterologous desensitization (English)

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28 July 2017

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2

Hui Zheng

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28 July 2017

Ping-Yee Law

5

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author name string

Ji Chu

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1

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28 July 2017

Yuhan Zhang

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3

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28 July 2017

Horace H Loh

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28 July 2017

5 January 2010

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28 July 2017

13

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inferred from page(s)

published in

Cellular Signalling

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28 July 2017

22

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28 July 2017

684-696

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28 July 2017

4

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describes a project that uses

28 July 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2833358/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine

21 June 2018

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Src phosphorylation of micro-receptor is responsible for the receptor switching from an inhibitory to a stimulatory signal.

21 June 2018

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Functional coupling of mu-receptor-Galphai-tethered proteins in AtT20 cells

21 June 2018

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Agonist-selective signaling is determined by the receptor location within the membrane domains.

21 June 2018

1 reference

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Morphine-induced mu-opioid receptor rapid desensitization is independent of receptor phosphorylation and beta-arrestins

21 June 2018

1 reference

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Pre-treatment with a PKC or PKA inhibitor prevents the development of morphine tolerance but not physical dependence in mice

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Phosphorylation of Galpha11 protein contributes to agonist-induced desensitization of 5-HT2A receptor signaling

21 June 2018

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Increased response to morphine in mice lacking protein kinase C epsilon

21 June 2018

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mu opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis

21 June 2018

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Agonist-selective mechanisms of mu-opioid receptor desensitization in human embryonic kidney 293 cells

21 June 2018

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The linoleic acid derivative DCP-LA selectively activates PKC-epsilon, possibly binding to the phosphatidylserine binding site

21 June 2018

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Molecular and cellular basis of cannabinoid and opioid interactions.

21 June 2018

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Chronic morphine acts via a protein kinase Cgamma-G(beta)-adenylyl cyclase complex to augment phosphorylation of G(beta) and G(betagamma) stimulatory adenylyl cyclase signaling

21 June 2018

1 reference

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Desensitization of G protein-coupled receptors and neuronal functions

21 June 2018

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G-protein coupled receptors in lipid rafts and caveolae: how, when and why do they go there?

21 June 2018

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G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal

21 June 2018

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Mechanisms of cross-talk between G-protein-coupled receptors resulting in enhanced release of intracellular Ca2+.

21 June 2018

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Ca2+-independent protein kinase Cs mediate heterologous desensitization of leukocyte chemokine receptors by opioid receptors

21 June 2018

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Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice.

21 June 2018

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Opioid receptor genes inactivated in mice: the highlights.

21 June 2018

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Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions

21 June 2018

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Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawal

21 June 2018

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Bidirectional heterologous desensitization of opioid and chemokine receptors

21 June 2018

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Acute opioid receptor desensitization and tolerance: is there a link?

21 June 2018

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Phosphorylation of GRK2 by protein kinase C abolishes its inhibition by calmodulin.

21 June 2018

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Heterologous desensitization of response mediated by selective PKC-dependent phosphorylation of G(i-1) and G(i-2).

21 June 2018

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Molecular mechanisms and regulation of opioid receptor signaling

21 June 2018

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21 June 2018

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What molecular events underlie heterologous desensitization? Focus on "receptor phosphorylation does not mediate cross talk between muscarinic M(3) and bradykinin B(2) receptors".

21 June 2018

1 reference

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3-Isobutyl-1-methylxanthine inhibits basal mu-opioid receptor phosphorylation and reverses acute morphine tolerance and dependence in mice

21 June 2018

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GABA(B) receptor-mediated stimulation of adenylyl cyclase activity in membranes of rat olfactory bulb

21 June 2018

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Morphine-activated opioid receptors elude desensitization by beta-arrestin

21 June 2018

1 reference

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G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization

21 June 2018

1 reference

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Anchoring proteins for protein kinase C: a means for isozyme selectivity

21 June 2018

1 reference

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Protein kinase C phosphorylates G12 alpha and inhibits its interaction with G beta gamma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2833358

Opioids mobilize calcium from inositol 1,4,5-trisphosphate-sensitive stores in NG108-15 cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2833358

Enhancement of the rate of GTP hydrolysis in rat brain by repeated kappa-opioid treatment

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2833358

The sites of phosphorylation by protein kinase C and an intact SH2 domain are required for the enhanced response to beta-adrenergic agonists in cells overexpressing c-src

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2833358

Protein kinase C phosphorylates the inhibitory guanine-nucleotide-binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2833358

Hormonal regulation of Gi2 alpha-subunit phosphorylation in intact hepatocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2833358

Concentration-related effects of morphine on cognition and motor control in human subjects

21 June 2018

1 reference

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Role of protein kinase C and mu-opioid receptor (MOPr) desensitization in tolerance to morphine in rat locus coeruleus neurons.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2833358

NMDAR-nNOS generated zinc recruits PKCgamma to the HINT1-RGS17 complex bound to the C terminus of Mu-opioid receptors.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2833358

Constitutive activity of the cannabinoid CB1 receptor regulates the function of co-expressed Mu opioid receptors

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2833358

Involvement of the protein kinase Cgamma isoform in development of tolerance to nitrous oxide-induced antinociception in mice.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2833358

Determination of the role of conventional, novel and atypical PKC isoforms in the expression of morphine tolerance in mice

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2833358

Interactions between CB1 cannabinoid and mu opioid receptors mediating inhibition of neurotransmitter release in rat nucleus accumbens core

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2833358

Short- and long-term regulation of adenylyl cyclase activity by delta-opioid receptor are mediated by Galphai2 in neuroblastoma N2A cells

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2833358

Compartment-specific localization of cannabinoid 1 (CB1) and mu-opioid receptors in rat nucleus accumbens

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2833358

The expression of a high level of morphine antinociceptive tolerance in mice involves both PKC and PKA.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2833358

Genetic dissociation of opiate tolerance and physical dependence in delta-opioid receptor-1 and preproenkephalin knock-out mice.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2833358

Prolonged reversal of morphine tolerance with no reversal of dependence by protein kinase C inhibitors

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2833358

Inhibition of spinal protein kinase Calpha expression by an antisense oligonucleotide attenuates morphine infusion-induced tolerance

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2833358

Reduced development of tolerance to the analgesic effects of morphine and clonidine in PKC gamma mutant mice

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2833358

Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2833358

Delta-opioid receptors on astroglial cells in primary culture: mobilization of intracellular free calcium via a pertussis sensitive G protein.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2833358

A mitogen-activated protein kinase pathway is required for mu-opioid receptor desensitization

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2833358

Differential mu opiate receptor phosphorylation and desensitization induced by agonists and phorbol esters.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2833358

Enkephalin activates the phospholipase C/Ca2+ system through cross-talk between opioid receptors and P2-purinergic or bradykinin receptors in NG 108-15 cells. A permissive role for pertussis toxin-sensitive G-proteins

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2833358

Mu and delta opioid receptor desensitization in undifferentiated human neuroblastoma SHSY5Y cells.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2833358

Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: an in situ hybridization study

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2833358

The effect of intrinsic efficacy on opioid tolerance

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2833358

Protein kinase C contains a pseudosubstrate prototope in its regulatory domain

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20043990

12 December 2020

inferred from PubMed ID database lookup

nPKCepsilon and NMDA receptors participate in neuroprotection induced by morphine pretreatment

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20043990

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1016/J.CELLSIG.2009.12.003

1 reference

28 July 2017

1 reference

28 July 2017

1 reference