Regulation of NF-kappaB by the HTLV-1 Tax protein. (Q33706869)

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11 December 2019

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24 August 2020

Regulation of NF-kappaB by the HTLV-1 Tax protein (English)

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Human T-lymphotropic virus 1

11 December 2019

main subject

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24 August 2020

X H Li

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11 December 2019

R B Gaynor

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2

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11 December 2019

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1 January 1999

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11 December 2019

7 references

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page(s)

233-245

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issue

4-6

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I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding

11 December 2019

cites work

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12 December 2020

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

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12 December 2020

Diseases associated with HTLV-I: virus, IL-2 receptor dysregulation and redox regulation

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12 December 2020

Constitutive phosphorylation and turnover of I kappa B alpha in human T-cell leukemia virus type I-infected and Tax-expressing T cells

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12 December 2020

Tax induces nuclear translocation of NF-kappa B through dissociation of cytoplasmic complexes containing p105 or p100 but does not induce degradation of I kappa B alpha/MAD3

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12 December 2020

IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

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12 December 2020

Localization of human T-cell leukemia virus type 1 tax to subnuclear compartments that overlap with interchromatin speckles

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12 December 2020

Function and activation of NF-kappa B in the immune system

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12 December 2020

Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering.

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12 December 2020

Identification and characterization of an IkappaB kinase

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12 December 2020

The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

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12 December 2020

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12 December 2020

Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism

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12 December 2020

Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation

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12 December 2020

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

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12 December 2020

Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway

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12 December 2020

Mechanisms of human T-cell leukemia virus-induced leukemogenesis

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12 December 2020

Type I human T cell leukemia virus tax protein transforms rat fibroblasts through the cyclic adenosine monophosphate response element binding protein/activating transcription factor pathway

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12 December 2020

HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization

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12 December 2020

The death domain kinase RIP mediates the TNF-induced NF-kappaB signal

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12 December 2020

Inhibition of NF-kappa B by sodium salicylate and aspirin

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12 December 2020

Activation of NF-kappa B by the Tax protein of HTLV-1.

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12 December 2020

The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats.

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12 December 2020

Regulation of the human interleukin-2 receptor alpha chain promoter: activation of a nonfunctional promoter by the transactivator gene of HTLV-I.

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12 December 2020

NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation

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12 December 2020

NF-kappa B and rel proteins in innate immunity

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12 December 2020

Recognition of bZIP proteins by the human T-cell leukaemia virus transactivator Tax.

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12 December 2020

Cytoplasmic forms of human T-cell leukemia virus type 1 Tax induce NF-kappaB activation

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12 December 2020

Transcriptional activator Tax of HTLV-1 binds to the NF-kappa B precursor p105

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12 December 2020

IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

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12 December 2020

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

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12 December 2020

Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease

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12 December 2020

Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-kappa B subunit

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12 December 2020

I kappa B: a specific inhibitor of the NF-kappa B transcription factor

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12 December 2020

Evidence in support of a role for human T-cell leukemia virus type I Tax in activating NF-kappa B via stimulation of signaling pathways

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12 December 2020

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli

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12 December 2020

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

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12 December 2020

I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention

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12 December 2020

Human T-cell leukemia virus type I Tax-protein-mediated activation of NF-kappa B from p100 (NF-kappa B2)-inhibited cytoplasmic reservoirs

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12 December 2020

Structure, regulation and function of NF-kappa B

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12 December 2020

CHUK, a new member of the helix-loop-helix and leucine zipper families of interacting proteins, contains a serine-threonine kinase catalytic domain.

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12 December 2020

Apoptotic, non-apoptotic, and anti-apoptotic pathways of tumor necrosis factor signalling

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12 December 2020

Human T-cell leukemia virus type I Tax associates with and is negatively regulated by the NF-kappa B2 p100 gene product: implications for viral latency

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12 December 2020

HTLV-1 Tax enhances NF-kappa B2 expression and binds to the products p52 and p100, but does not suppress the inhibitory function of p100.

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12 December 2020

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12 December 2020

A molecular mechanism for human T-cell leukemia virus latency and Tax transactivation

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12 December 2020

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12 December 2020

Identification of the gene responsible for human T-cell leukaemia virus transcriptional regulation

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12 December 2020

NF-IL6 and NF-kappa B in cytokine gene regulation

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12 December 2020

Mechanism of DNA-binding enhancement by the human T-cell leukaemia virus transactivator Tax.

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12 December 2020

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B

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12 December 2020

The NF-kappa B and I kappa B proteins: new discoveries and insights

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12 December 2020

Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation

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12 December 2020

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12 December 2020

Human T-cell lymphotropic virus type I (HTLV-I) transcriptional activator, Tax, enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction

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12 December 2020

IKAP is a scaffold protein of the IkappaB kinase complex

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12 December 2020

Anchoring of CREB binding protein to the human T-cell leukemia virus type 1 promoter: a molecular mechanism of Tax transactivation

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12 December 2020

RIP and FADD: two "death domain"-containing proteins can induce apoptosis by convergent, but dissociable, pathways

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12 December 2020

The human T-cell leukemia virus type 1 transactivator protein Tax colocalizes in unique nuclear structures with NF-kappaB proteins

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12 December 2020

Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300

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12 December 2020

Cellular transformation by human T-cell leukemia virus type I.

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12 December 2020

NF-kappa B: ten years after

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12 December 2020

Inhibition of TNF-induced apoptosis by NF-kappa B.

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12 December 2020

Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro

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12 December 2020

Transcription factors in immune-mediated disease

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12 December 2020

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

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12 December 2020

TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

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12 December 2020

A transgenic mouse model for human neurofibromatosis

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12 December 2020

Correction of radiation sensitivity in ataxia telangiectasia cells by a truncated I kappa B-alpha

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12 December 2020

Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation.

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12 December 2020

Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases

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12 December 2020

TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

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12 December 2020

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

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12 December 2020

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

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12 December 2020

Nuclear factor-kappa B.

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12 December 2020

Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila

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12 December 2020

Direct interaction of CREB protein with 21 bp Tax-response elements of HTLV-ILTR

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12 December 2020

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

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12 December 2020

MEK kinase is involved in tumor necrosis factor alpha-induced NF-kappaB activation and degradation of IkappaB-alpha.

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12 December 2020

Human T cell leukemia virus type I (HTLV-I) and human diseases

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12 December 2020

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

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12 December 2020

Dorsal, an embryonic polarity gene in Drosophila, is homologous to the vertebrate proto-oncogene, c-rel.

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12 December 2020

Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha

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12 December 2020

Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP.

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12 December 2020

N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity

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12 December 2020

Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1.

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12 December 2020

The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta

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12 December 2020

HTLV-1 21 bp repeat sequences facilitate stable association between Tax and CREB to increase CREB binding affinity

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12 December 2020

FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis

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12 December 2020

The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells

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12 December 2020

Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

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12 December 2020

Inactivation of IkappaBbeta by the tax protein of human T-cell leukemia virus type 1: a potential mechanism for constitutive induction of NF-kappaB

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12 December 2020

HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation.

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12 December 2020

CHUK, a conserved helix-loop-helix ubiquitous kinase, maps to human chromosome 10 and mouse chromosome 19

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12 December 2020

Dif, a dorsal-related gene that mediates an immune response in Drosophila.

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12 December 2020

Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity

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12 December 2020

JNK or IKK, AP-1 or NF-kappaB, which are the targets for MEK kinase 1 action?

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12 December 2020

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation

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12 December 2020

Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus, type I.

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12 December 2020

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

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12 December 2020

Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs

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12 December 2020

Kappa B site-dependent induction of gene expression by diverse inducers of nuclear factor kappa B requires Raf-1.

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12 December 2020

Towards a better aspirin

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12 December 2020

The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice

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12 December 2020

Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

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12 December 2020

Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation

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12 December 2020

The tax oncoprotein of human T-cell leukemia virus type 1 associates with and persistently activates IkappaB kinases containing IKKalpha and IKKbeta

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12 December 2020

Complex formation between CREB and Tax enhances the binding affinity of CREB for the human T-cell leukemia virus type 1 21-base-pair repeats

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12 December 2020

Tax protein of HTLV-1 destabilizes the complexes of NF-kappa B and I kappa B-alpha and induces nuclear translocation of NF-kappa B for transcriptional activation

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12 December 2020

Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras.

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12 December 2020

Pro-inflammatory signaling: last pieces in the NF-kappaB puzzle?

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12 December 2020

Persistent activation of NF-kappa B/Rel by human T-cell leukemia virus type 1 tax involves degradation of I kappa B beta.

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12 December 2020

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

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12 December 2020

Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

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12 December 2020

Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

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12 December 2020

Kinetic analysis of human T-cell leukemia virus type I Tax-mediated activation of NF-kappa B

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12 December 2020

Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases

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12 December 2020

Nuclear uptake control of NF-kappa B by MAD-3, an I kappa B protein present in the nucleus

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12 December 2020

NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway

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12 December 2020

Human T-cell leukemia virus type I Tax activation of NF-kappa B/Rel involves phosphorylation and degradation of I kappa B alpha and RelA (p65)-mediated induction of the c-rel gene

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12 December 2020

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

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12 December 2020

MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

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12 December 2020

Death receptors: signaling and modulation

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12 December 2020

Pleiotropic effect of the human T-cell leukemia virus Tax protein on the DNA binding activity of eukaryotic transcription factors

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12 December 2020

10.1017/S0016672399003808

Identifiers

DOI

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11 December 2019

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11 December 2019

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