The Molecular Mechanisms of Anesthetic Action: Updates and Cutting Edge Developments from the Field of Molecular Modeling (Q33678016)

28 July 2017

1 reference

title

The Molecular Mechanisms of Anesthetic Action: Updates and Cutting Edge Developments from the Field of Molecular Modeling (English)

1 reference

28 July 2017

Edward J Bertaccini

1

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28 July 2017

8 July 2010

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28 July 2017

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28 July 2017

3

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28 July 2017

7

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28 July 2017

2178-2196

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Creative Commons Attribution 4.0 International

28 July 2017

start time

8 July 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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A Unitary Anesthetic Binding Site at High Resolution

21 June 2018

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GABA-induced intersubunit conformational movement in the GABAA receptor alpha 1M1-beta 2M3 transmembrane subunit interface: experimental basis for homology modeling of an intravenous anesthetic binding site

21 June 2018

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X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

21 June 2018

1 reference

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Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

21 June 2018

1 reference

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Tryptophan mutations at azi-etomidate photo-incorporation sites on alpha1 or beta2 subunits enhance GABAA receptor gating and reduce etomidate modulation

21 June 2018

1 reference

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X-ray structure of a prokaryotic pentameric ligand-gated ion channel

21 June 2018

1 reference

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Cross-linking of sites involved with alcohol action between transmembrane segments 1 and 3 of the glycine receptor following activation

21 June 2018

1 reference

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Homology modeling and molecular dynamics simulations of the alpha1 glycine receptor reveals different states of the channel

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036663

State-dependent cross-linking of the M2 and M3 segments: functional basis for the alignment of GABAA and acetylcholine receptor M3 segments.

21 June 2018

1 reference

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Structural basis for high-affinity volatile anesthetic binding in a natural 4-helix bundle protein

21 June 2018

1 reference

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Refined structure of the nicotinic acetylcholine receptor at 4A resolution

21 June 2018

1 reference

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Charge selectivity of the Cys-loop family of ligand-gated ion channels.

21 June 2018

1 reference

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Weak intermolecular associations and anesthesia

21 June 2018

1 reference

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Tryptophan scanning mutagenesis in TM4 of the GABA(A) receptor alpha1 subunit: implications for modulation by inhaled anesthetics and ion channel structure

21 June 2018

1 reference

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Unique assignment of inter-subunit association in GABA(A) alpha 1 beta 3 gamma 2 receptors determined by molecular modeling

21 June 2018

1 reference

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Molecular modelling of specific and non-specific anaesthetic interactions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036663

Molecular modeling of ligand-gated ion channels: progress and challenges

21 June 2018

1 reference

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Anesthetics and ion channels: molecular models and sites of action

21 June 2018

1 reference

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Evidence for a common binding cavity for three general anesthetics within the GABAA receptor.

21 June 2018

1 reference

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Specific binding sites for alcohols and anesthetics on ligand-gated ion channels

21 June 2018

1 reference

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A designed four-alpha-helix bundle that binds the volatile general anesthetic halothane with high affinity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036663

Evaluation of forcefields for molecular mechanics/dynamics calculations involving halogenated anesthetics.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036663

Multiple sequence alignment with Clustal X

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036663

Structural basis for the inhibition of firefly luciferase by a general anesthetic

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036663

Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036663

The lateral pressure profile in membranes: a physical mechanism of general anesthesia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036663

Comparative protein modelling by satisfaction of spatial restraints

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036663

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036663

Polyhalogenated and perfluorinated compounds that disobey the Meyer-Overton hypothesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036663

Stereospecific dihaloalkane binding in a pH-sensitive cavity in cubic insulin crystals

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036663

Molecular dynamics simulation of anesthetic-phospholipid bilayer interactions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036663

Is membrane expansion relevant to anaesthesia?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036663

Mechanisms of general anesthesia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036663

What solvent best represents the site of action of inhaled anesthetics in humans, rats, and dogs?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036663

Role of hydrogen bonding in general anesthesia.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036663

Anesthetic inhibition of firefly luciferase, a protein model for general anesthesia, does not exhibit pressure reversal

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036663

Halothane binds in the adenine-specific niche of crystalline adenylate kinase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036663

Zur Theorie der Alkoholnarkose

21 June 2018

1 reference

Partitioning of four modern volatile general anesthetics into solvents that model buried amino acid side-chains.

21 January 2018

1 reference

The common chemical motifs within anesthetic binding sites

21 January 2018

1 reference

Comparative modeling of a GABAA alpha1 receptor using three crystal structures as templates

21 January 2018

1 reference

Halothane binding to a G protein coupled receptor in retinal membranes by photoaffinity labeling.

21 January 2018

1 reference

Identification of a general anesthetic binding site in the diacylglycerol-binding domain of protein kinase Cdelta

21 January 2018

1 reference

Identification of binding sites in the nicotinic acetylcholine receptor for [3H]azietomidate, a photoactivatable general anesthetic

21 January 2018

1 reference

Determinants of volatile general anesthetic potency: a preliminary three-dimensional pharmacophore for halogenated anesthetics.

21 January 2018

1 reference

Predicting the transmembrane secondary structure of ligand-gated ion channels.

21 January 2018

1 reference

Homology modeling of a human glycine alpha 1 receptor reveals a plausible anesthetic binding site

21 January 2018

1 reference

Identification of acetylcholine receptor channel-lining residues in the M1 segment of the alpha-subunit.

21 January 2018

1 reference

Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the alpha subunit.

21 January 2018

1 reference

A conserved tyrosine in the beta2 subunit M4 segment is a determinant of gamma-aminobutyric acid type A receptor sensitivity to propofol

21 January 2018

1 reference

Identification of a GABAA receptor anesthetic binding site at subunit interfaces by photolabeling with an etomidate analog.

21 January 2018

1 reference

General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036663

A molecular description of how noble gases and nitrogen bind to a model site of anesthetic action

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036663

Nicotinic acetylcholine receptor at 9 A resolution.

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27713348

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifying the lipid-protein interface of the Torpedo nicotinic acetylcholine receptor: secondary structure implications

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27713348

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3390/PH3072178

1 reference

28 July 2017

1 reference

28 July 2017

1 reference

PubMed ID

27713348