A phosphopeptide mimetic prodrug targeting the SH2 domain of Stat3 inhibits tumor growth and angiogenesis. (Q33661939)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23350355%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

title

A phosphopeptide mimetic prodrug targeting the SH2 domain of Stat3 inhibits tumor growth and angiogenesis (English)

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22 February 2020

7

Robert C Bast

1 reference

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22 February 2020

author name string

Edmond J Auzenne

1

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22 February 2020

Jim Klostergaard

2

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22 February 2020

Pijus K Mandal

3

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22 February 2020

Warren S Liao

4

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22 February 2020

Zhen Lu

5

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22 February 2020

Fengqin Gao

6

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22 February 2020

Fredika M Robertson

8

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22 February 2020

John S McMurray

9

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22 February 2020

publication date

1 January 2012

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Journal of Experimental Therapeutics & Oncology

22 February 2020

published in

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22 February 2020

volume

10

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22 February 2020

page(s)

155-162

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22 February 2020

issue

2

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STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small cell lung carcinoma.

22 February 2020

cites work

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Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3.

21 June 2018

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Identification of Purine-Scaffold Small-Molecule Inhibitors of Stat3 Activation by QSAR Studies

21 June 2018

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Design, synthesis, and in vitro characterization of novel hybrid peptidomimetic inhibitors of STAT3 protein

21 June 2018

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21 June 2018

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A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processes

21 June 2018

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The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors

21 June 2018

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Structure-affinity relationships of glutamine mimics incorporated into phosphopeptides targeted to the SH2 domain of signal transducer and activator of transcription 3.

21 June 2018

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Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities.

21 June 2018

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Synthesis of phosphatase-stable, cell-permeable peptidomimetic prodrugs that target the SH2 domain of Stat3

21 June 2018

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Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.

21 June 2018

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Conformationally constrained peptidomimetic inhibitors of signal transducer and activator of transcription. 3: Evaluation and molecular modeling.

21 June 2018

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Chemical probes that competitively and selectively inhibit Stat3 activation

21 June 2018

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Function of mitochondrial Stat3 in cellular respiration

21 June 2018

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STAT 3 as a target for cancer drug discovery

21 June 2018

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Roles of unphosphorylated STATs in signaling

21 June 2018

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Inhibition of tumor metastasis by a growth factor receptor bound protein 2 Src homology 2 domain-binding antagonist.

21 June 2018

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STAT3: a critical transcription activator in angiogenesis.

21 June 2018

1 reference

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Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains

21 June 2018

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Solid-phase synthesis of Stat3 inhibitors incorporating O-carbamoylserine and O-carbamoylthreonine as glutamine mimics

21 June 2018

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Design and synthesis of phosphotyrosine peptidomimetic prodrugs

21 June 2018

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HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas.

21 June 2018

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Inhibition of angiogenesis by growth factor receptor bound protein 2-Src homology 2 domain bound antagonists

21 June 2018

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Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity.

21 June 2018

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SH2 domains: role, structure and implications for molecular medicine

21 June 2018

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Structural requirements for signal transducer and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motif

21 June 2018

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The STATs of cancer--new molecular targets come of age

21 June 2018

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Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor

21 June 2018

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Transcription factors as targets for cancer therapy

21 June 2018

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21 June 2018

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Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

21 June 2018

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Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation

21 June 2018

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Antagonists of the Src homology 2 (SH2) domains of Grb2, Src, Lck and ZAP-70.

21 June 2018

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SH2 domain inhibition: a problem solved?

21 June 2018

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Potent blockade of hepatocyte growth factor-stimulated cell motility, matrix invasion and branching morphogenesis by antagonists of Grb2 Src homology 2 domain interactions

21 June 2018

1 reference

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The role of STATs in transcriptional control and their impact on cellular function

21 June 2018

1 reference

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Inhibition of the ras-dependent mitogenic pathway by phosphopeptide prodrugs with antiproliferative properties

21 June 2018

1 reference

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Progress in the development of inhibitors of SH2 domains

21 June 2018

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Selective GRB2 SH2 inhibitors as anti-Ras therapy

21 June 2018

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Effect of potent and selective inhibitors of the Grb2 SH2 domain on cell motility

21 June 2018

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Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation

21 June 2018

1 reference

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Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors

21 June 2018

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Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

21 June 2018

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Cell density dependent increase of constitutive signal transducers and activators of transcription 3 activity in melanoma cells is mediated by Janus kinases.

21 June 2018

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Structural basis for the binding of high affinity phosphopeptides to Stat3.

30 October 2018

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Investigation of the binding determinants of phosphopeptides targeted to the SRC homology 2 domain of the signal transducer and activator of transcription 3. Development of a high-affinity peptide inhibitor

30 October 2018

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Identification of a high-affinity phosphopeptide inhibitor of Stat3.

30 October 2018

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An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects

30 October 2018

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12 December 2020

Structure-activity relationships of small phosphopeptides, inhibitors of Grb2 SH2 domain, and their prodrugs

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12 December 2020

On modeling peptidomimetics in complex with the SH2 domain of Stat3

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12 December 2020

New syntheses of tetrazolylmethylphenylalanine and O-malonyltyrosine as pTyr mimetics for the design of STAT3 dimerization inhibitors

1 reference

12 December 2020

Design and synthesis of a new, conformationally constrained, macrocyclic small-molecule inhibitor of STAT3 via 'click chemistry'

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12 December 2020

Src homology-2 domains: structure, mechanisms, and drug discovery

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12 December 2020

Targeting STAT3 in cancer: how successful are we?

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12 December 2020

Identifiers

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22 February 2020

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