The sulfhydryl containing compounds WR-2721 and glutathione as radio- and chemoprotective agents. A review, indications for use and prospects (Q33653212)

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English	The sulfhydryl containing compounds WR-2721 and glutathione as radio- and chemoprotective agents. A review, indications for use and prospects	scientific article

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scholarly article

1 reference

Europe PubMed Central

28 July 2017

4 references

12 November 2019

20 November 2019

25 November 2020

1 December 2020

The sulfhydryl containing compounds WR-2721 and glutathione as radio- and chemoprotective agents. A review, indications for use and prospects (English)

1 reference

Europe PubMed Central

28 July 2017

organic compound, having C-P covalent bound

1 reference

12 November 2019

1 reference

20 November 2019

1 reference

25 November 2020

radiation protection agent

1 reference

1 December 2020

1 reference

based on heuristic

inferred from title

author name string

Hospers GA

1

1 reference

Europe PubMed Central

28 July 2017

Eisenhauer EA

2

1 reference

Europe PubMed Central

28 July 2017

de Vries EG

3

1 reference

Europe PubMed Central

28 July 2017

language of work or name

0 references

publication date

1 May 1999

5 references

Europe PubMed Central

28 July 2017

12 November 2019

20 November 2019

25 November 2020

1 December 2020

British Journal of Cancer

5 references

Europe PubMed Central

28 July 2017

12 November 2019

20 November 2019

25 November 2020

1 December 2020

80

1 reference

Europe PubMed Central

28 July 2017

5-6

1 reference

Europe PubMed Central

28 July 2017

629-638

1 reference

Europe PubMed Central

28 July 2017

https://scigraph.springernature.com/pub.10.1038/sj.bjc.6690404

0 references

Selective cytoprotection with amifostine in concurrent radiochemotherapy for head and neck cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

Endothelial P-selectin expression is reduced in advanced primary melanoma and melanoma metastasis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

Pharmacologic approaches to protection against radiation-induced lethality and other damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

Comparison of five agents in protecting the cochlea against the ototoxic effects of cisplatin in the hamster

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

Stimulation of hematopoiesis by amifostine in patients with myelodysplastic syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

Cardioprotection with dexrazoxane for doxorubicin-containing therapy in advanced breast cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

Amifostine (Ethyol): pharmacokinetic and pharmacodynamic effects in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

Intraperitoneal cisplatin plus intravenous cyclophosphamide versus intravenous cisplatin plus intravenous cyclophosphamide for stage III ovarian cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

Amifostine does not alter the antitumor activity of cisplatin in a pre-clinical model of testicular cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

Amifostine and chemotherapy-related thrombocytopenia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

Cytoprotective agents for anthracyclines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

Amifostine pretreatment for protection against cyclophosphamide-induced and cisplatin-induced toxicities: results of a randomized control trial in patients with advanced ovarian cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

Carboplatin combined with amifostine, a bone marrow protectant, in the treatment of non-small-cell lung cancer: a randomised phase II study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

High-dose cisplatin and cyclophosphamide with glutathione in the treatment of advanced ovarian cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

Randomized clinical trial of mitomycin-C with or without pretreatment with WR-2721 in patients with advanced colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

Cisplatin-associated neurotoxicity: can it be prevented?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

Protection of Normal Tissue from the Cytotoxic Effects of Chemotherapy and Radiation by Amifostine: Clinical Experiences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

Four cycles of BEP versus an alternating regime of PVB and BEP in patients with poor-prognosis metastatic testicular non-seminoma; a randomised study of the EORTC Genitourinary Tract Cancer Cooperative Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

HPLC and 31P NMR characterization of the reaction between antitumor platinum agents and the phosphorothioate chemoprotective agent S-2-(3-aminopropylamino)ethylphosphorothioic acid (WR-2721).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

Clinical trial of the effect of S-2-(3-aminopropylamino)-ethylphosphorothioic acid (WR-2721) (NSC 296961) on the toxicity of cyclophosphamide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

Inhibition of radiation carcinogenesis in mice by S-2-(3-aminopropylamino)-ethylphosphorothioic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

Phase I Controlled trials of WR-2721 and cyclophosphamide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

2-[(Aminopropyl)amino]ethanethiol (WR1065) is anti-neoplastic and anti-mutagenic when given during 60Co gamma-ray irradiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

Radioprotection of cells in culture by WR-2721 and derivatives: form of the drug responsible for protection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

Protective effect of reduced glutathione against cisplatin-induced renal and systemic toxicity and its influence on the therapeutic activity of the antitumor drug

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

Late cardiac effects of doxorubicin therapy for acute lymphoblastic leukemia in childhood

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

Antioxidant and glutathione-related enzymatic activities in rat sciatic nerve

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

The first normal oral mucosa epithelium in which gamma-glutamyl transpeptidase activity has been detected

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

The radioprotector WR-2721 reduces neutron-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in mouse splenocytes when administered prior to or following irradiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

Distribution of 35 S-Labeled WR-2721 in Normal and Malignant Tissues of the Mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

21 June 2018

Repression of c-myc gene expression by the thiol and disulfide forms of the cytoprotector amifostine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

30 October 2018

Glutathione reduces the toxicity and improves quality of life of women diagnosed with ovarian cancer treated with cisplatin: results of a double-blind, randomised trial.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

30 October 2018

The effects of cycloheximide and WR-1065 on radiation-induced repair processes: a mechanism for chemoprevention

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

30 October 2018

Audiological findings in a Phase I protocol investigating the effect of WR 2721, high-dose cisplatin and radiation therapy in patients with locally advanced cervical carcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

30 October 2018

A randomised double-blind placebo controlled clinical trial assessing the tolerability and efficacy of glutathione as an adjuvant to escalating doses of cisplatin in the treatment of advanced ovarian cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

30 October 2018

Cisplatin neuropathy. Risk factors, prognosis, and protection by WR-2721.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362304

30 October 2018

Amifostine, cisplatin, and vinblastine in metastatic non-small-cell lung cancer: a report of high response rates and prolonged survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of amifostine and its metabolites in patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amifostine protects normal tissues from paclitaxel toxicity while cytotoxicity against tumour cells is maintained

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WR-1065, an active metabolite of the cytoprotector amifostine, affects phosphorylation of topoisomerase II alpha leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disposition of the radioprotector ethiofos in the rhesus monkey. Influence of route of administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy and safety of high-dose cisplatin and cyclophosphamide with glutathione protection in the treatment of bulky advanced epithelial ovarian cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of the Effective Radioprotective Dose of WR-2721 in Humans through an Interspecies Tissue Distribution Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Active versus passive absorption kinetics as the basis for selective protection of normal tissues by S-2-(3-aminopropylamino)-ethylphosphorothioic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential protection against cytotoxic chemotherapeutic effects on bone marrow CFUs by Wr-2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The modification of melphalan toxicity in tumor bearing mice by S-2-(3-aminopropylamino)-ethylphosphorothioic acid (WR2721)

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection and potentiation of nitrogen mustard cytotoxicity by WR-2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective modification of glutathione metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dephosphorylation of WR-2721 with mouse tissue homogenates

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alkaline phosphatase promotes radioprotection and accumulation of WR-1065 in V79-171 cells incubated in medium containing WR-2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection against cis-diamminedichloroplatinum cytotoxicity and mutagenicity in V79 cells by 2-[(aminopropyl)amino]ethanethiol

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effects of 2-[(aminopropyl)amino] ethanethiol against bleomycin and nitrogen mustard-induced mutagenicity in V79 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human pharmacokinetics of WR-2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I/II trials of WR-2721 and cis-platinum

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uptake of WR-2721 derivatives by cells in culture: identification of the transported form of the drug

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple forms of gamma-glutamyl transpeptidase in human submandibular gland

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-dose intravenous glutathione in man. Pharmacokinetics and effects on cyst(e)ine in plasma and urine

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The chemical reactivity of the modulating agent WR2721 (ethiofos) and its main metabolites with the antitumor agents cisplatin and carboplatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antimutagenic effects of radioprotector WR-2721 against fission-spectrum neurons and 60Co gamma-rays in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of glutathione administration on the disposition of free and total platinum in patients after administration of cisplatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of radiation with or without WR-2721 in advanced rectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Topical application of WR-2721 to prevent radiation-induced proctosigmoiditis. A phase I/II trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced glutathione protects against cisplatin-induced neurotoxicity in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase II study of combination chemotherapy in advanced ovarian carcinoma with cisplatin and cyclophosphamide plus reduced glutathione as potential protective agent against cisplatin toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of the modulating agent WR2721 on myelotoxicity and antitumour activity in carboplatin-treated mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morbidity of ischemic heart disease in early breast cancer 15-20 years after adjuvant radiotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Late cardiac effects of adjuvant therapy: too soon to tell?

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amifostine (WR-2721) shortens the engraftment period of 4-hydroperoxycyclophosphamide-purged bone marrow in breast cancer patients receiving high-dose chemotherapy with autologous bone marrow support

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radioprotection of the rat small intestine with topical WR-2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accumulation of 99mTc-glutathione in head and neck tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-cytotoxic and anti-mutagenic mechanisms of action

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Topical Application of WR-2721 Achieves High Concentrations in the Rectal Wall

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amifostine improves the antileukemic therapeutic index of mafosfamide: implications for bone marrow purging

1 reference

https://pubmed.ncbi.nlm.nih.gov/10360638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxicity of cisplatin +/- reduced glutathione in the first-line treatment of advanced ovarian cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6690404

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.BJC.6690404

1 reference

Europe PubMed Central

28 July 2017

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0 references

1 reference

Europe PubMed Central

28 July 2017

1 reference

Europe PubMed Central

28 July 2017

ResearchGate publication ID

0 references

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