Chemoprevention of mouse intestinal tumorigenesis by the cyclin-dependent kinase inhibitor SNS-032 (Q33642396)

28 July 2017

title

Chemoprevention of mouse intestinal tumorigenesis by the cyclin-dependent kinase inhibitor SNS-032 (English)

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28 July 2017

Amelie Boquoi

1

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28 July 2017

Tina Chen

series ordinal

2

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28 July 2017

Greg H Enders

series ordinal

3

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28 July 2017

publication date

1 September 2009

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Cancer Prevention Research

28 July 2017

published in

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28 July 2017

volume

2

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28 July 2017

issue

9

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28 July 2017

page(s)

800-806

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SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples

28 July 2017

cites work

1 reference

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Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial

28 July 2018

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Concomitant DFMO and sulindac chemoprevention of colorectal adenomas: a major clinical advance

28 July 2018

1 reference

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The development of duodenal microadenomas in FAP patients: the human correlate of the Min mouse

28 July 2018

1 reference

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SNS-032 prevents tumor cell-induced angiogenesis by inhibiting vascular endothelial growth factor

28 July 2018

1 reference

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p16(Ink4a) inhibits histologic progression and angiogenic signaling in min colon tumors

28 July 2018

1 reference

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p27kip1 in intestinal tumorigenesis and chemoprevention in the mouse

28 July 2018

1 reference

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Preclinical and clinical development of the cyclin-dependent kinase inhibitor flavopiridol

28 July 2018

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Primary prevention of colorectal cancer: diet and drugs

28 July 2018

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Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status

28 July 2018

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Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists

28 July 2018

1 reference

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Ulcerative colitis and colon cancer: more controversy than clarity

28 July 2018

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Inflammatory bowel disease and colon cancer: a review

28 July 2018

1 reference

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Alterations in DNA methylation: a fundamental aspect of neoplasia

28 July 2018

1 reference

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A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice

28 July 2018

1 reference

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Combination chemoprevention of intestinal carcinogenesis in a murine model of familial adenomatous polyposis

28 July 2018

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Drugs to prevent colon cancer show promise, but hurdles remain for chemoprevention

30 October 2018

1 reference

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A phase 1 study of SNS-032 (formerly BMS-387032), a potent inhibitor of cyclin-dependent kinases 2, 7 and 9 administered as a single oral dose and weekly infusion in patients with metastatic refractory solid tumors

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819381

Chemoprevention of familial adenomatous polyposis by low doses of atorvastatin and celecoxib given individually and in combination to APCMin mice.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819381

Cyclin-dependent kinase pathways as targets for cancer treatment

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819381

Dextran sodium sulfate strongly promotes colorectal carcinogenesis in Apc(Min/+) mice: inflammatory stimuli by dextran sodium sulfate results in development of multiple colonic neoplasms.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819381

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819381

S and G2 phase roles for Cdk2 revealed by inducible expression of a dominant-negative mutant in human cells

30 October 2018

1 reference

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Role of the INK4a locus in tumor suppression and cell mortality.

30 October 2018

1 reference

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Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers

30 October 2018

1 reference

12 December 2020

Inhibition of colon tumor progression and angiogenesis by the Ink4a/Arf locus

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12 December 2020

Chemoprevention of colorectal cancer

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12 December 2020

In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine)

1 reference

12 December 2020

Loss of Apc+ in intestinal adenomas from Min mice

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12 December 2020

Hypermethylation of the p16INK4a promoter in colectomy specimens of patients with long-standing and extensive ulcerative colitis

1 reference

12 December 2020

The role of mutant Apc in the development of dysplasia and cancer in the mouse model of dextran sulfate sodium-induced colitis

1 reference

12 December 2020

p16(INK4): involvement early and often in gastrointestinal malignancies

1 reference

12 December 2020

Rare CpG Island Methylator Phenotype in Ulcerative Colitis–Associated Neoplasias

1 reference

12 December 2020

K-ras mutations in aberrant crypt foci, adenomas and adenocarcinomas during azoxymethane-induced colon carcinogenesis

1 reference

12 December 2020

p16(INK4a) expression begins early in human colon neoplasia and correlates inversely with markers of cell proliferation

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12 December 2020

Colon cancer in ulcerative colitis

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12 December 2020

10.1158/1940-6207.CAPR-09-0053

Identifiers

DOI

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28 July 2017

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28 July 2017

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