Convergent transcription through a long CAG tract destabilizes repeats and induces apoptosis (Q33637169)

28 July 2017

title

Convergent transcription through a long CAG tract destabilizes repeats and induces apoptosis (English)

1 reference

28 July 2017

1 reference

Yunfu Lin

1

1 reference

28 July 2017

Mei Leng

series ordinal

2

1 reference

28 July 2017

Ma Wan

series ordinal

3

1 reference

28 July 2017

John H Wilson

series ordinal

4

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28 July 2017

language of work or name

English

0 references

publication date

20 July 2010

1 reference

Molecular and Cellular Biology

28 July 2017

published in

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28 July 2017

volume

30

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28 July 2017

issue

18

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28 July 2017

page(s)

4435-4451

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Repeat expansion disease: progress and puzzles in disease pathogenesis

28 July 2017

cites work

1 reference

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21 June 2018

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R loops stimulate genetic instability of CTG.CAG repeats

21 June 2018

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Epigenetic silencing in Friedreich ataxia is associated with depletion of CTCF (CCCTC-binding factor) and antisense transcription

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset

21 June 2018

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Transcription destabilizes triplet repeats

21 June 2018

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Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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G4-forming sequences in the non-transcribed DNA strand pose blocks to T7 RNA polymerase and mammalian RNA polymerase II.

21 June 2018

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Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline

21 June 2018

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Genome-wide demethylation promotes triplet repeat instability independently of homologous recombination

21 June 2018

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21 June 2018

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21 June 2018

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An antisense transcript spanning the CGG repeat region of FMR1 is upregulated in premutation carriers but silenced in full mutation individuals

21 June 2018

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21 June 2018

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RPA and ATR link transcriptional stress to p53

21 June 2018

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Transcription-induced CAG repeat contraction in human cells is mediated in part by transcription-coupled nucleotide excision repair

21 June 2018

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OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

21 June 2018

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Trinucleotide Repeat Disorders

21 June 2018

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Polyglutamine neurodegenerative diseases and regulation of transcription: assembling the puzzle

21 June 2018

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Bidirectional expression of CUG and CAG expansion transcripts and intranuclear polyglutamine inclusions in spinocerebellar ataxia type 8.

21 June 2018

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21 June 2018

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TopBP1 activates the ATR-ATRIP complex

21 June 2018

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ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.

21 June 2018

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Transcription promotes contraction of CAG repeat tracts in human cells

21 June 2018

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21 June 2018

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21 June 2018

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Antisense transcription in the mammalian transcriptome

21 June 2018

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Inducible control of transgene expression with ecdysone receptor: gene switches with high sensitivity, robust expression, and reduced size

21 June 2018

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Activation of DNA damage signaling

21 June 2018

1 reference

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Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria.

21 June 2018

1 reference

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Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation

21 June 2018

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Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

21 June 2018

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MSH2-dependent germinal CTG repeat expansions are produced continuously in spermatogonia from DM1 transgenic mice.

21 June 2018

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The contribution of <i>cis</i>-elements to disease-associated repeat instability: clinical and experimental evidence

21 June 2018

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Nuclease-deficient FEN-1 blocks Rad51/BRCA1-mediated repair and causes trinucleotide repeat instability

21 June 2018

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Selectable system for monitoring the instability of CTG/CAG triplet repeats in mammalian cells.

21 June 2018

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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

21 June 2018

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A new mathematical model for relative quantification in real-time RT-PCR

21 June 2018

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The GAA*TTC triplet repeat expanded in Friedreich's ataxia impedes transcription elongation by T7 RNA polymerase in a length and supercoil dependent manner

21 June 2018

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Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice

21 June 2018

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Mitochondria and apoptosis

21 June 2018

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Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system

21 June 2018

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RNA polymerase II stalled at a thymine dimer: footprint and effect on excision repair

21 June 2018

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Trinucleotide repeats that expand in human disease form hairpin structures in vitro

21 June 2018

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Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

21 June 2018

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SCA8 mRNA expression suggests an antisense regulation of KLHL1 and correlates to SCA8 pathology

21 June 2018

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CREB-binding protein modulates repeat instability in a Drosophila model for polyQ disease

30 October 2018

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Fen1 does not control somatic hypermutability of the (CTG)(n)*(CAG)(n) repeat in a knock-in mouse model for DM1.

30 October 2018

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Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

30 October 2018

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Antisense transcription and heterochromatin at the DM1 CTG repeats are constrained by CTCF.

30 October 2018

1 reference

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Genome-wide demethylation destabilizes CTG.CAG trinucleotide repeats in mammalian cells

30 October 2018

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Somatic expansion behaviour of the (CTG)n repeat in myotonic dystrophy knock-in mice is differentially affected by Msh3 and Msh6 mismatch-repair proteins

30 October 2018

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Trinucleotide expansion in haploid germ cells by gap repair

30 October 2018

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A triplex-forming sequence from the human c-MYC promoter interferes with DNA transcription

30 October 2018

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12 December 2020

Transcription - guarding the genome by sensing DNA damage

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12 December 2020

Alternative structures in duplex DNA formed within the trinucleotide repeats of the myotonic dystrophy and fragile X loci

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12 December 2020

atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity

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12 December 2020

Transcriptional properties of RNA polymerase II within triplet repeat-containing DNA from the human myotonic dystrophy and fragile X loci

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12 December 2020

Identifiers

DOI

10.1128/MCB.00332-10

1 reference

28 July 2017

1 reference

28 July 2017

1 reference