Testosterone supplementation reverses sarcopenia in aging through regulation of myostatin, c-Jun NH2-terminal kinase, Notch, and Akt signaling pathways (Q33634392)

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English	Testosterone supplementation reverses sarcopenia in aging through regulation of myostatin, c-Jun NH2-terminal kinase, Notch, and Akt signaling pathways	scientific article

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scholarly article

1 reference

Europe PubMed Central

28 July 2017

Testosterone supplementation reverses sarcopenia in aging through regulation of myostatin, c-Jun NH2-terminal kinase, Notch, and Akt signaling pathways (English)

1 reference

Europe PubMed Central

28 July 2017

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Ekaterina L Kovacheva

1

1 reference

Europe PubMed Central

28 July 2017

Amiya P Sinha Hikim

2

1 reference

Europe PubMed Central

28 July 2017

Ruoqing Shen

3

1 reference

Europe PubMed Central

28 July 2017

Indranil Sinha

4

1 reference

Europe PubMed Central

28 July 2017

Indrani Sinha-Hikim

5

1 reference

Europe PubMed Central

28 July 2017

language of work or name

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publication date

18 December 2009

1 reference

Europe PubMed Central

28 July 2017

1 reference

Europe PubMed Central

28 July 2017

151

1 reference

Europe PubMed Central

28 July 2017

628-638

1 reference

Europe PubMed Central

28 July 2017

2

1 reference

Europe PubMed Central

28 July 2017

Testosterone and growth hormone improve body composition and muscle performance in older men.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Valproic acid activates the PI3K/Akt/mTOR pathway in muscle and ameliorates pathology in a mouse model of Duchenne muscular dystrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Mouse model of testosterone-induced muscle fiber hypertrophy: involvement of p38 mitogen-activated protein kinase-mediated Notch signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Mitogen-activated protein kinase signaling in male germ cell apoptosis in the rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Notch1 is an effector of Akt and hypoxia in melanoma development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

PAX3/7 expression coincides with MyoD during chronic skeletal muscle overload

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Nuclear apoptosis contributes to sarcopenia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

The emerging biology of satellite cells and their therapeutic potential

1 reference

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21 June 2018

Involvement of c-Jun NH2-terminal kinase and nitric oxide-mediated mitochondria-dependent intrinsic pathway signaling in cardiotoxin-induced muscle cell death: role of testosterone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Decorin gene transfer promotes muscle cell differentiation and muscle regeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Alterations in myostatin expression are associated with changes in cardiac left ventricular mass but not ejection fraction in the mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Skeletal muscle apoptosis, sarcopenia and frailty at old age.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Drug insight: Testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Myostatin regulation of muscle development: molecular basis, natural mutations, physiopathological aspects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

The intricacies of p21 phosphorylation: protein/protein interactions, subcellular localization and stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Myostatin regulates cardiomyocyte growth through modulation of Akt signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Signaling pathways in skeletal muscle remodeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Cellular and molecular signatures of muscle regeneration: current concepts and controversies in adult myogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Apoptosis in muscle atrophy: relevance to sarcopenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Aging, stem cells and tissue regeneration: lessons from muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Rejuvenation of aged progenitor cells by exposure to a young systemic environment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Muscle regeneration in the prolonged absence of myostatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Beginnings of a signal-transduction pathway for bioenergetic control of cell survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Conditional activation of akt in adult skeletal muscle induces rapid hypertrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Myostatin mutation associated with gross muscle hypertrophy in a child

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Mitogen-activated protein kinases in apoptosis regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Androgenic regulation of oxidative stress in the rat prostate: involvement of NAD(P)H oxidases and antioxidant defense machinery during prostatic involution and regrowth

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Myostatin negatively regulates satellite cell activation and self-renewal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

The true face of JNK activation in apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Muscle satellite cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

H2O2 and 4-hydroxynonenal mediate amyloid beta-induced neuronal apoptosis by activating JNKs and p38MAPK.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Metabolic profiling of cell growth and death in cancer: applications in drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Sarcopenia: current concepts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Glucose-6-phosphate dehydrogenase and the oxidative pentose phosphate cycle protect cells against apoptosis induced by low doses of ionizing radiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Importance of glucose-6-phosphate dehydrogenase activity in cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Epidemiology of sarcopenia among the elderly in New Mexico

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Double muscling in cattle due to mutations in the myostatin gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Changes in fibre type, number and diameter in developing and ageing skeletal muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

21 June 2018

Down-regulation of Akt/mammalian target of rapamycin signaling pathway in response to myostatin overexpression in skeletal muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

30 October 2018

Effects of testosterone supplementation on skeletal muscle fiber hypertrophy and satellite cells in community-dwelling older men.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

30 October 2018

Apoptotic responses to hindlimb suspension in gastrocnemius muscles from young adult and aged rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

30 October 2018

Skeletal muscle atrophy is associated with an increased expression of myostatin and impaired satellite cell function in the portacaval anastamosis rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

30 October 2018

Age-associated changes in SAPK/JNK and p38 MAPK signaling in response to the generation of ROS by 3-nitropropionic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

30 October 2018

Testosterone-induced muscle hypertrophy is associated with an increase in satellite cell number in healthy, young men.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

30 October 2018

The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

30 October 2018

Longitudinal changes in body composition in older men and women: role of body weight change and physical activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

30 October 2018

Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817626

30 October 2018

Epidemiology of sarcopenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/20022929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myostatin, a negative regulator of muscle growth, functions by inhibiting myoblast proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20022929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of diminished oestrogen and androgen levels on development of skeletal muscle fibres in hypogonadal mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20022929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Notch-mediated restoration of regenerative potential to aged muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/20022929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of spermatogenesis by androgens in gonadotropin-deficient (hpg) mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20022929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prolonged absence of myostatin reduces sarcopenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/20022929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormalities of mitochondrial functioning can partly explain the metabolic disorders encountered in sarcopenic gastrocnemius

1 reference

https://pubmed.ncbi.nlm.nih.gov/20022929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antagonism of myostatin enhances muscle regeneration during sarcopenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/20022929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Androgens negatively regulate myostatin expression in an androgen-dependent skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/20022929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of myostatin signaling by c-Jun N-terminal kinase in C2C12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20022929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1210/EN.2009-1177

1 reference

Europe PubMed Central

28 July 2017

1 reference

Europe PubMed Central

28 July 2017

1 reference

Europe PubMed Central

28 July 2017

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