Immunotoxin complementation of HAART to deplete persisting HIV-infected cell reservoirs (Q33604776)

28 July 2017

Immunotoxin complementation of HAART to deplete persisting HIV-infected cell reservoirs (English)

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28 July 2017

2

Ira Pastan

1 reference

28 July 2017

Edward A Berger

1

1 reference

28 July 2017

10 June 2010

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28 July 2017

1 reference

28 July 2017

6

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28 July 2017

6

1 reference

28 July 2017

e1000803

1 reference

Creative Commons CC0 License

28 July 2017

start time

10 June 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

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cites work

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Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target

28 July 2018

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A simian immunodeficiency virus-infected macaque model to study viral reservoirs that persist during highly active antiretroviral therapy

28 July 2018

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Analysis of human immunodeficiency virus type 1 viremia and provirus in resting CD4+ T cells reveals a novel source of residual viremia in patients on antiretroviral therapy

28 July 2018

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HIV interactions with monocytes and dendritic cells: viral latency and reservoirs

28 July 2018

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Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy

28 July 2018

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HIV latency: present knowledge, future directions

28 July 2018

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Phase II trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with hairy cell leukemia

28 July 2018

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The challenge of finding a cure for HIV infection

28 July 2018

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Targeted tumor therapies at a glance

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HIV infection and the gastrointestinal immune system

28 July 2018

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Short communication: Activating stimuli enhance immunotoxin-mediated killing of HIV-infected macrophages

28 July 2018

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Eradication of HIV: current challenges and new directions

28 July 2018

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Pseudomonas exotoxin A: from virulence factor to anti-cancer agent

28 July 2018

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Optimizing denileukin diftitox (Ontak) therapy

28 July 2018

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An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes

28 July 2018

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Viral reservoirs, residual viremia, and the potential of highly active antiretroviral therapy to eradicate HIV infection.

28 July 2018

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Host and microbial cells as targets for armed antibodies in the treatment of infectious diseases

28 July 2018

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Suppression of viremia and evolution of human immunodeficiency virus type 1 drug resistance in a macaque model for antiretroviral therapy

28 July 2018

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Hide-and-seek: the challenge of viral persistence in HIV-1 infection

28 July 2018

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Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection

28 July 2018

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Targeted killing of virally infected cells by radiolabeled antibodies to viral proteins

28 July 2018

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Elimination of HIV-1 infection by treatment with a doxorubicin-conjugated anti-envelope antibody.

28 July 2018

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Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells

28 July 2018

1 reference

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Pathogenesis of macrophage tropic HIV-1.

28 July 2018

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The discovery of HIV as the cause of AIDS.

28 July 2018

1 reference

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Targeting therapeutics to an exposed and conserved binding element of the HIV-1 fusion protein

28 July 2018

1 reference

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Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia

28 July 2018

1 reference

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Macrophage are the principal reservoir and sustain high virus loads in rhesus macaques after the depletion of CD4+ T cells by a highly pathogenic simian immunodeficiency virus/HIV type 1 chimera (SHIV): Implications for HIV-1 infections of humans

28 July 2018

1 reference

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Specific killing of HIV-infected lymphocytes by a recombinant immunotoxin directed against the HIV-1 envelope glycoprotein

28 July 2018

1 reference

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An anti-CD45RO immunotoxin eliminates T cells latently infected with HIV-1 in vitro

28 July 2018

1 reference

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Reconsidering targeted toxins to eliminate HIV infection: you gotta have HAART

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883583

In vitro evolution of a neutralizing human antibody to human immunodeficiency virus type 1 to enhance affinity and broaden strain cross-reactivity

28 July 2018

1 reference

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Animal model for the therapy of acquired immunodeficiency syndrome with reverse transcriptase inhibitors

28 July 2018

1 reference

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Treatment of HIV tissue culture infection with monoclonal antibody-ricin A chain conjugates.

28 July 2018

1 reference

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CD4-Pseudomonas exotoxin hybrid protein blocks the spread of human immunodeficiency virus infection in vitro and is active against cells expressing the envelope glycoproteins from diverse primate immunodeficiency retroviruses

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883583

Recombinant CD4-Pseudomonas exotoxin hybrid protein displays HIV-specific cytotoxicity without affecting MHC class II-dependent functions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883583

Anti-HIV activity of CD4-Pseudomonas exotoxin on infected primary human lymphocytes and monocyte/macrophages

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883583

Activity of CD4-Pseudomonas exotoxin against cells expressing diverse forms of the HIV and SIV envelope glycoproteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883583

Elimination of infectious human immunodeficiency virus from human T-cell cultures by synergistic action of CD4-Pseudomonas exotoxin and reverse transcriptase inhibitors.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883583

A recombinant diphtheria toxin related human CD4 fusion protein specifically kills HIV infected cells which express gp120 but selects fusion toxin resistant cells which carry HIV

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883583

Inhibition of HIV-1 RNA production by the diphtheria toxin-related IL-2 fusion proteins DAB486IL-2 and DAB389IL-2.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883583

Quantitative assay for testing susceptibility of HIV isolates to zidovudine and sCD4 (178)-PE40

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883583

A Step Ahead on the HIV Collaboratory

28 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1000803

Paul Ehrlich's magic bullet concept: 100 years of progress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1000803

HIV-infected cells are killed by rCD4-ricin A chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1000803

Immunotoxin therapy of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1000803

Continuous presence of CD4-PE40 is required for antiviral activity against single-passage HIV isolates and infected peripheral blood mononuclear cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1000803

Use of recombinant soluble CD4 Pseudomonas exotoxin, a novel immunotoxin, for treatment of persons infected with human immunodeficiency virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1000803

Failure of short-term CD4-PE40 infusions to reduce virus load in human immunodeficiency virus-infected persons

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1000803

Anti-HIV-1 immunotoxin 3B3(Fv)-PE38: enhanced potency against clinical isolates in human PBMCs and macrophages, and negligible hepatotoxicity in macaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1000803

Chimeric toxins targeted to the human immunodeficiency virus type 1 envelope glycoprotein augment the in vivo activity of combination antiretroviral therapy in thy/liv-SCID-Hu mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1000803

Molecular Characterization, Reactivation, and Depletion of Latent HIV

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1000803

Increased affinity and stability of an anti-HIV-1 envelope immunotoxin by structure-based mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1000803

Antibody-based HIV-1 vaccines: recent developments and future directions

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1000803

Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1000803

Inferior clinical outcome of the CD4+ cell count-guided antiretroviral treatment interruption strategy in the SMART study: role of CD4+ Cell counts and HIV RNA levels during follow-up.

21 January 2018

1 reference

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21 January 2018

1 reference

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Lowering the isoelectric point of the Fv portion of recombinant immunotoxins leads to decreased nonspecific animal toxicity without affecting antitumor activity

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883583

Selective killing of HIV-infected cells by recombinant human CD4-Pseudomonas exotoxin hybrid protein

30 October 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1000803

Primary HIV-1 isolates refractory to neutralization by soluble CD4 are potently inhibited by CD4-Pseudomonas exotoxin

21 January 2018

1 reference

12 December 2020

Selective elimination of HIV-1-infected cells with an interleukin-2 receptor-specific cytotoxin

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12 December 2020

Role of CD25+ and CD25-T cells in acute HIV infection in vitro

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12 December 2020

In vivo efficacy of anti-glycoprotein 41, but not anti-glycoprotein 120, immunotoxins in a mouse model of HIV infection

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12 December 2020

Gemtuzumab ozogamicin in the treatment of acute myeloid leukemia

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12 December 2020

10.1371/JOURNAL.PPAT.1000803

Identifiers

DOI

1 reference

28 July 2017

1 reference

28 July 2017

1 reference

PubMed ID

20548940