Small-molecule modulators of inward rectifier K+ channels: recent advances and future possibilities (Q33603023)

28 July 2017

1 reference

title

Small-molecule modulators of inward rectifier K+ channels: recent advances and future possibilities (English)

1 reference

28 July 2017

Gautam Bhave

1

1 reference

28 July 2017

Daniel Lonergan

series ordinal

2

1 reference

28 July 2017

Brian A Chauder

series ordinal

3

1 reference

28 July 2017

Jerod S Denton

series ordinal

4

1 reference

28 July 2017

publication date

1 May 2010

1 reference

Future Medicinal Chemistry

28 July 2017

published in

1 reference

28 July 2017

volume

2

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28 July 2017

issue

5

1 reference

28 July 2017

page(s)

757-774

1 reference

Inwardly rectifying potassium channels: their structure, function, and physiological roles

28 July 2017

cites work

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The Kir channel immunoglobulin domain is essential for Kir1.1 (ROMK) thermodynamic stability, trafficking and gating

21 June 2018

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Dietary K regulates ROMK channels in connecting tubule and cortical collecting duct of rat kidney

21 June 2018

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21 June 2018

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Preliminary SAR studies on non-apamin-displacing 4-(aminomethylaryl)pyrrazolopyrimidine K(Ca) channel blockers

21 June 2018

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An improved terminology and classification of Bartter-like syndromes

21 June 2018

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Inward rectifier potassium currents as a target for atrial fibrillation therapy

21 June 2018

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Common variants in genes underlying monogenic hypertension and hypotension and blood pressure in the general population

21 June 2018

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Rare independent mutations in renal salt handling genes contribute to blood pressure variation

21 June 2018

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Characterization of in vivo and in vitro electrophysiological and antiarrhythmic effects of a novel IKACh blocker, NIP-151: a comparison with an IKr-blocker dofetilide

21 June 2018

1 reference

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The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel

21 June 2018

1 reference

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Behavioral characterization of mice lacking GIRK/Kir3 channel subunits.

21 June 2018

1 reference

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Mutations in KCNJ13 cause autosomal-dominant snowflake vitreoretinal degeneration

21 June 2018

1 reference

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Modulation of pain transmission by G-protein-coupled receptors

21 June 2018

1 reference

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K(ATP) channel pharmacogenomics: from bench to bedside

21 June 2018

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Crystal structure of a Kir3.1-prokaryotic Kir channel chimera

21 June 2018

1 reference

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H bonding at the helix-bundle crossing controls gating in Kir potassium channels

21 June 2018

1 reference

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21 June 2018

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Functional significance of channels and transporters expressed in the inner ear and kidney

21 June 2018

1 reference

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Inhibition of astroglial inwardly rectifying Kir4.1 channels by a tricyclic antidepressant, nortriptyline.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Blockade by NIP-142, an antiarrhythmic agent, of carbachol-induced atrial action potential shortening and GIRK1/4 channel

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Inwardly rectifying potassium channels (Kir) in central nervous system glia: a special role for Kir4.1 in glial functions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Chronic inhibition of cardiac Kir2.1 and HERG potassium channels by celastrol with dual effects on both ion conductivity and protein trafficking.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Molecular and cellular diversity of neuronal G-protein-gated potassium channels.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Phosphorylation-regulated endoplasmic reticulum retention signal in the renal outer-medullary K+ channel (ROMK)

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

K(ATP) channel therapeutics at the bedside

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Mechanism of the voltage sensitivity of IRK1 inward-rectifier K+ channel block by the polyamine spermine

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

A thallium-sensitive, fluorescence-based assay for detecting and characterizing potassium channel modulators in mammalian cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Function recovery after chemobleaching (FRAC): evidence for activity silent membrane receptors on cell surface

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Effects of the atrial antiarrhythmic drug AVE0118 on cardiac ion channels.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Lifetime risk for development of atrial fibrillation: the Framingham Heart Study

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Inhibition of G protein-activated inwardly rectifying K+ channels by various antidepressant drugs

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Mechanism of rectification in inward-rectifier K+ channels

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

What is the optimal serum potassium level in cardiovascular patients?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Novel neuroprotective K+ channel inhibitor identified by high-throughput screening in yeast

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Gating of GIRK channels: details of an intricate, membrane-delimited signaling complex

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Crystal structure of the potassium channel KirBac1.1 in the closed state

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Inhibition of G protein-activated inwardly rectifying K+ channels by fluoxetine (Prozac).

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Absence of small conductance K+ channel (SK) activity in apical membranes of thick ascending limb and cortical collecting duct in ROMK (Bartter's) knockout mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

An inward rectifier K(+) channel at the basolateral membrane of the mouse distal convoluted tubule: similarities with Kir4-Kir5.1 heteromeric channels

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

G protein-gated inwardly rectifying potassium channels are targets for volatile anesthetics.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Mechanism underlying bupivacaine inhibition of G protein-gated inwardly rectifying K+ channels

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

G-protein mediated gating of inward-rectifier K+ channels

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Genetic inactivation of an inwardly rectifying potassium channel (Kir4.1 subunit) in mice: phenotypic impact in retina

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Inhibition by various antipsychotic drugs of the G-protein-activated inwardly rectifying K(+) (GIRK) channels expressed in xenopus oocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

pH gating of ROMK (K(ir)1.1) channels: control by an Arg-Lys-Arg triad disrupted in antenatal Bartter syndrome

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

A mutation linked with Bartter's syndrome locks Kir 1.1a (ROMK1) channels in a closed state

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Direct block of native and cloned (Kir2.1) inward rectifier K+ channels by chloroethylclonidine.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Inwardly rectifying K+ channel Kir7.1 is highly expressed in thyroid follicular cells, intestinal epithelial cells and choroid plexus epithelial cells: implication for a functional coupling with Na+,K+-ATPase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

A novel inward rectifier K+ channel with unique pore properties

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Inward rectifier potassium channels

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Non-potassium-sparing diuretics and risk of sudden cardiac death.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Subunit positional effects revealed by novel heteromeric inwardly rectifying K+ channels

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Cloning and expression of an inwardly rectifying ATP-regulated potassium channel

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Effects of antidiuretic hormone on cellular conductive pathways in mouse medullary thick ascending limbs of Henle: II. Determinants of the ADH-mediated increases in transepithelial voltage and in net Cl− absorption

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Effects of antidiuretic hormone on cellular conductive pathways in mouse medullary thick ascending limbs of Henle: I. ADH increases transcellular conductance pathways

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Luminal influences on potassium secretion: sodium concentration and fluid flow rate

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification

21 June 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.179

Classification and rescue of ROMK mutations underlying hyperprostaglandin E syndrome/antenatal Bartter syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.179

Initial SAR studies on apamin-displacing 2-aminothiazole blockers of calcium-activated small conductance potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.179

A phosphorylation-dependent export structure in ROMK (Kir 1.1) channel overrides an endoplasmic reticulum localization signal

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.179

Expression of inwardly rectifying potassium channel subunits in native human retinal pigment epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.179

Strong voltage-dependent inward rectification of inward rectifier K+ channels is caused by intracellular spermine.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.179

Electrostatic tuning of Mg2+ affinity in an inward-rectifier K+ channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.179

Gating of inwardly rectifying K+ channels localized to a single negatively charged residue.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.179

Selective inhibition of Kir currents by antihistamines.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.179

Bi-directional effects of GABA(B) receptor agonists on the mesolimbic dopamine system

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.179

Evaluation of the role of I(KACh) in atrial fibrillation using a mouse knockout model.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.179

Abnormal heart rate regulation in GIRK4 knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.179

Hyperalgesia and blunted morphine analgesia in G protein-gated potassium channel subunit knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.179

Spinal G-protein-gated K+ channels formed by GIRK1 and GIRK2 subunits modulate thermal nociception and contribute to morphine analgesia.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.179

Inhibitory effects of the antiepileptic drug ethosuximide on G protein-activated inwardly rectifying K+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.179

Classic D1 dopamine receptor antagonist R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH23390) directly inhibits G protein-coupled inwardly rectifying potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.179

The dual modulation of GIRK1/GIRK2 channels by opioid receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.179

Identification of an inward rectifier potassium channel gene expressed in mouse cortical astrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.179

Kir potassium channel subunit expression in retinal glial cells: implications for spatial potassium buffering

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.179

Time course of inner ear degeneration and deafness in mice lacking the Kir4.1 potassium channel subunit.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.179

Inhibition of astroglial Kir4.1 channels by selective serotonin reuptake inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.179

Secretory modulation of basolateral membrane inwardly rectified K(+) channel in guinea pig distal colonic crypts

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.179

Decreased cocaine self-administration in Kir3 potassium channel subunit knockout mice

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Contribution of the Kir3.1 subunit to the muscarinic-gated atrial potassium channel IKACh

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

Kir4.1 potassium channel subunit is crucial for oligodendrocyte development and in vivo myelination.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

ROMK1 (Kir1.1) causes apoptosis and chronic silencing of hippocampal neurons.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883187

30 October 2018

1 reference

12 December 2020

Maxi-K channels contribute to urinary potassium excretion in the ROMK-deficient mouse model of Type II Bartter's syndrome and in adaptation to a high-K diet

1 reference

12 December 2020

GABA spillover activates postsynaptic GABA(B) receptors to control rhythmic hippocampal activity

1 reference

12 December 2020

Localization of inward rectifier potassium channel Kir7.1 in the basolateral membrane of distal nephron and collecting duct

1 reference

12 December 2020

Genetic heterogeneity of Bartter's syndrome revealed by mutations in the K+ channel, ROMK

1 reference

12 December 2020

Inhibitory effect of amiodarone on the muscarinic acetylcholine receptor-operated potassium current in guinea pig atrial cells

1 reference

12 December 2020

1 reference

12 December 2020

Roles of Na-K-2Cl and Na-Cl cotransporters and ROMK potassium channels in urinary concentrating mechanism

1 reference

12 December 2020

Two channels for one job

1 reference

12 December 2020

Kir4.1/Kir5.1 channel forms the major K+ channel in the basolateral membrane of mouse renal collecting duct principal cells

1 reference

12 December 2020

Identifiers

DOI

10.4155/FMC.10.179

1 reference

28 July 2017

1 reference

28 July 2017

1 reference