Inhibition of hepatic microsomal triglyceride transfer protein - a novel therapeutic option for treatment of homozygous familial hypercholesterolemia (Q33599900)

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Language	Label	Description	Also known as
English	Inhibition of hepatic microsomal triglyceride transfer protein - a novel therapeutic option for treatment of homozygous familial hypercholesterolemia	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

28 July 2017

10 references

24 March 2019

22 April 2019

31 July 2019

8 August 2019

17 September 2019

2 October 2019

7 October 2019

28 November 2019

15 December 2019

18 December 2020

Inhibition of hepatic microsomal triglyceride transfer protein - a novel therapeutic option for treatment of homozygous familial hypercholesterolemia (English)

1 reference

Europe PubMed Central

28 July 2017

hypercholesterolemia

0 references

familial hypercholesterolemia

9 references

24 March 2019

22 April 2019

31 July 2019

8 August 2019

17 September 2019

2 October 2019

7 October 2019

28 November 2019

15 December 2019

homozygous familial hypercholesterolemia

0 references

cell surface receptor

1 reference

31 July 2019

1 reference

8 August 2019

heterocyclic compound

1 reference

17 September 2019

mechanism of action

1 reference

2 October 2019

human digestive system

1 reference

7 October 2019

transport protein

1 reference

28 November 2019

membrane protein

1 reference

15 December 2019

1 reference

based on heuristic

inferred from title

anticholesteremic agents

1 reference

18 December 2020

1 reference

based on heuristic

inferred from title

1

object named as

Alpo Vuorio

1 reference

Europe PubMed Central

28 July 2017

Petri T Kovanen

3

object named as

Petri T Kovanen

1 reference

Europe PubMed Central

28 July 2017

author name string

Matti J Tikkanen

2

1 reference

Europe PubMed Central

28 July 2017

language of work or name

0 references

publication date

6 May 2014

11 references

Europe PubMed Central

28 July 2017

24 March 2019

22 April 2019

31 July 2019

8 August 2019

17 September 2019

2 October 2019

7 October 2019

28 November 2019

15 December 2019

18 December 2020

Vascular Health and Risk Management

11 references

Europe PubMed Central

28 July 2017

24 March 2019

22 April 2019

31 July 2019

8 August 2019

17 September 2019

2 October 2019

7 October 2019

28 November 2019

15 December 2019

18 December 2020

10

1 reference

Europe PubMed Central

28 July 2017

263-270

1 reference

Europe PubMed Central

28 July 2017

copyright license

Creative Commons Attribution-NonCommercial

10 references

24 March 2019

22 April 2019

31 July 2019

8 August 2019

17 September 2019

2 October 2019

7 October 2019

28 November 2019

15 December 2019

18 December 2020

on focus list of Wikimedia project

0 references

Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Guidelines on the use of therapeutic apheresis in clinical practice-evidence-based approach from the Writing Committee of the American Society for Apheresis: the sixth special issue.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Recent advances in the treatment of homozygous familial hypercholesterolaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Microsomal transfer protein inhibition in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Management of familial hypercholesterolemia: a review of the recommendations from the National Lipid Association Expert Panel on Familial Hypercholesterolemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

The evidence-base for the efficacy of lipoprotein apheresis in combating cardiovascular disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Low-density lipoprotein receptor gene familial hypercholesterolemia variant database: update and pathological assessment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Homozygous familial hypercholesterolemia: current perspectives on diagnosis and treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Homozygous familial hypercholesterolemia in Lebanon: a genotype/phenotype correlation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Preemptive liver transplantation in a child with familial hypercholesterolemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Efficacy criteria and cholesterol targets for LDL apheresis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Longitudinal evaluation and assessment of cardiovascular disease in patients with homozygous familial hypercholesterolemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Long-term safety and efficacy of low-density lipoprotein apheresis in childhood for homozygous familial hypercholesterolemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Current management of severe homozygous hypercholesterolaemias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Hypercholesterolemic valvulopathy: an aspect of malignant atherosclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Microsomal triglyceride transfer protein (MTP) inhibitors: discovery of clinically active inhibitors using high-throughput screening and parallel synthesis paradigms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

The role of the microsomal triglygeride transfer protein in abetalipoproteinemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Analysis of LDL receptor gene mutations in Italian patients with homozygous familial hypercholesterolemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Expanded-dose simvastatin is effective in homozygous familial hypercholesterolaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

An inhibitor of the microsomal triglyceride transfer protein inhibits apoB secretion from HepG2 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Deficiency of low density lipoprotein receptors in liver and adrenal gland of the WHHL rabbit, an animal model of familial hypercholesterolemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Regulation of plasma cholesterol by lipoprotein receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Heart-liver transplantation in a patient with familial hypercholesterolaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Familial defective apolipoprotein B-100: low density lipoproteins with abnormal receptor binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Two common low density lipoprotein receptor gene mutations cause familial hypercholesterolemia in Afrikaners

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Familial hypobeta-lipoproteinemia: studies in 13 kindreds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Prenatal diagnosis of homozygous familial hypercholesterolaemia. Expression of a genetic receptor disease in utero

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

14 July 2018

Effect of the proprotein convertase subtilisin/kexin 9 monoclonal antibody, AMG 145, in homozygous familial hypercholesterolemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

30 October 2018

Emerging low-density lipoprotein therapies: Microsomal triglyceride transfer protein inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

30 October 2018

Lomitapide for homozygous familial hypercholesterolaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

30 October 2018

Apheresis in homozygous familial hypercholesterolemia: the results of a follow-up of all Norwegian patients with homozygous familial hypercholesterolemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

30 October 2018

Reduction in mortality in subjects with homozygous familial hypercholesterolemia associated with advances in lipid-lowering therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

30 October 2018

Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

30 October 2018

Liver transplantation for homozygous familial hypercholesterolemia: two case reports.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

30 October 2018

Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

30 October 2018

Low-density lipoprotein apheresis in children with familial hypercholesterolemia: follow-up to 21 years.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

30 October 2018

Non-invasive detection of aortic and coronary atherosclerosis in homozygous familial hypercholesterolemia by 64 slice multi-detector row computed tomography angiography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

30 October 2018

A dose-titration and comparative study of rosuvastatin and atorvastatin in patients with homozygous familial hypercholesterolaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

30 October 2018

Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

30 October 2018

Long-term effects of LDL apheresis in patients with severe hypercholesterolemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

30 October 2018

Diaminoindanes as microsomal triglyceride transfer protein inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

30 October 2018

MTP inhibitor decreases plasma cholesterol levels in LDL receptor-deficient WHHL rabbits by lowering the VLDL secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

30 October 2018

A host of hypercholesterolaemic homozygotes in South Africa.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018418

30 October 2018

Homozygous familial hypercholesterolemia among French Canadians in Québec Province

1 reference

https://pubmed.ncbi.nlm.nih.gov/24851052

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural history and cardiac manifestations of homozygous familial hypercholesterolaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/24851052

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo metabolism of apolipoproteins A-I and E in patients with abetalipoproteinemia: implications for the roles of apolipoproteins B and E in HDL metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/24851052

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits

1 reference

https://pubmed.ncbi.nlm.nih.gov/24851052

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipoprotein(a) is an independent risk factor for cardiovascular disease in heterozygous familial hypercholesterolemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/24851052

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sudden Death in a 4-Year-Old Boy: A Near-Complete Occlusion of the Coronary Artery Caused by an Aggressive Low-Density Lipoprotein Receptor Mutation (W556R) in Homozygous Familial Hypercholesterolemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/24851052

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular genetic epidemiology of homozygous familial hypercholesterolemia in the Hokuriku district of Japan

1 reference

https://pubmed.ncbi.nlm.nih.gov/24851052

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liver transplantation as treatment for familial homozygous hypercholesterolemia: too early or too late

1 reference

https://pubmed.ncbi.nlm.nih.gov/24851052

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liver transplantation as a treatment option for three siblings with homozygous familial hypercholesterolemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/24851052

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Guidelines for the management of familial hypercholesterolemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/24851052

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipoprotein(a) in homozygous familial hypercholesterolemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/24851052

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased secretion of ApoB follows inhibition of ApoB-MTP binding by a novel antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/24851052

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of cholesterol synthesis by atorvastatin in homozygous familial hypercholesterolaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/24851052

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The rebound of lipoproteins after LDL-apheresis. Kinetics and estimation of mean lipoprotein levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/24851052

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy of mevinolin as adjuvant therapy for refractory familial hypercholesterolaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/24851052

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Lebanese allele at the low density lipoprotein receptor locus. Nonsense mutation produces truncated receptor that is retained in endoplasmic reticulum

1 reference

https://pubmed.ncbi.nlm.nih.gov/24851052

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lovastatin therapy in receptor-negative homozygous familial hypercholesterolemia: Lack of effect on low-density lipoprotein concentrations or turnover

1 reference

https://pubmed.ncbi.nlm.nih.gov/24851052

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2147/VHRM.S36641

1 reference

Europe PubMed Central

28 July 2017

1 reference

Europe PubMed Central

28 July 2017

1 reference

Europe PubMed Central

28 July 2017

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