Simvastatin inhibited cardiac hypertrophy and fibrosis in apolipoprotein E-deficient mice fed a "Western-style diet" by increasing PPAR α and γ expression and reducing TC, MMP-9, and Cat S levels. (Q33577634)

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English	Simvastatin inhibited cardiac hypertrophy and fibrosis in apolipoprotein E-deficient mice fed a "Western-style diet" by increasing PPAR α and γ expression and reducing TC, MMP-9, and Cat S levels.	scientific article

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scholarly article

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13 February 2020

Simvastatin inhibited cardiac hypertrophy and fibrosis in apolipoprotein E-deficient mice fed a "Western-style diet" by increasing PPAR α and γ expression and reducing TC, MMP-9, and Cat S levels (English)

1 reference

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13 February 2020

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13 February 2020

author name string

Ping Ye

2

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13 February 2020

Ji-qiang He

3

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13 February 2020

Li Sheng

4

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13 February 2020

Lu-ya Wang

5

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13 February 2020

Jie Du

6

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13 February 2020

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13 September 2010

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13 February 2020

Acta Pharmacologica Sinica

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13 February 2020

31

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13 February 2020

10

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13 February 2020

1350-1358

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13 February 2020

https://scigraph.springernature.com/pub.10.1038/aps.2010.109

0 references

Molecular targets and regulators of cardiac hypertrophy.

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14 July 2018

Rosuvastatin inhibits norepinephrine-induced cardiac hypertrophy via suppression of Gh.

1 reference

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14 July 2018

Superoxide-dependent cathepsin activation is associated with hypertensive myocardial remodeling and represents a target for angiotensin II type 1 receptor blocker treatment

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14 July 2018

Differential roles of cardiomyocyte and macrophage peroxisome proliferator-activated receptor gamma in cardiac fibrosis.

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14 July 2018

Reversal of systemic hypertension-associated cardiac remodeling in chronic pressure overload myocardium by ciglitazone

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14 July 2018

Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease

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14 July 2018

Role of oxidative stress in cardiac hypertrophy and remodeling

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14 July 2018

Prevention of cardiac hypertrophy by atorvastatin in a transgenic rabbit model of human hypertrophic cardiomyopathy

1 reference

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14 July 2018

Cardiovascular functional phenotypes and pharmacological responses in apolipoprotein E deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012913

14 July 2018

Role of matrix metalloproteinases in hypertension-associated cardiac fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012913

14 July 2018

Increased expression of elastolytic cysteine proteases, cathepsins S and K, in the neointima of balloon-injured rat carotid arteries

1 reference

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14 July 2018

A novel pleiotropic effect of statins: prevention of cardiac hypertrophy by cholesterol-independent mechanisms

1 reference

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14 July 2018

Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy

1 reference

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14 July 2018

Dyslipidemia and an unfavorable fatty acid profile predict left ventricular hypertrophy 20 years later

1 reference

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14 July 2018

Association of pravastatin and left ventricular mass in hypercholesterolemic patients: role of 8-iso-prostaglandin f2alpha formation

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2010.109

21 January 2018

Atorvastatin improves peroxisome proliferator-activated receptor signaling in cardiac hypertrophy by preventing nuclear factor-kappa B activation.

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2010.109

21 January 2018

Matrix metalloproteinases and tissue remodeling in hypertrophic cardiomyopathy.

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2010.109

21 January 2018

Effect of mast cell stabilizers in hyperhomocysteinemia-induced cardiac hypertrophy in rats

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2010.109

21 January 2018

Cardiac hypertrophy is enhanced in PPAR -/- mice in response to chronic pressure overload

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2010.109

21 January 2018

Peroxisome proliferator-activated receptor gamma activators inhibit cardiac hypertrophy in cardiac myocytes

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2010.109

21 January 2018

Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in mice

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2010.109

21 January 2018

Lysosomal cysteine peptidase cathepsin L protects against cardiac hypertrophy through blocking AKT/GSK3beta signaling

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2010.109

21 January 2018

Cardiac hypertrophy during hypercholesterolemia and its amelioration with rosuvastatin and amlodipine

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2010.109

21 January 2018

Atorvastatin attenuating down-regulation of peroxisome proliferator-activated receptor gamma in preventing cardiac hypertrophy of rats in vitro and in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012913

31 October 2018

Aortic constriction exacerbates atherosclerosis and induces cardiac dysfunction in mice lacking apolipoprotein E

1 reference

https://pubmed.ncbi.nlm.nih.gov/20835264

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree

1 reference

https://pubmed.ncbi.nlm.nih.gov/20835264

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elastolytic cathepsin induction/activation system exists in myocardium and is upregulated in hypertensive heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/20835264

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/APS.2010.109

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13 February 2020

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13 February 2020

1 reference

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13 February 2020

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