Stability engineering of scFvs for the development of bispecific and multivalent antibodies (Q33574335)

28 July 2017

Stability engineering of scFvs for the development of bispecific and multivalent antibodies (English)

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28 July 2017

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Lisa J Croner

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author name string

Brian R Miller

1

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28 July 2017

Stephen J Demarest

2

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28 July 2017

Alexey Lugovskoy

3

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28 July 2017

Flora Huang

4

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28 July 2017

Xiufeng Wu

5

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28 July 2017

William B Snyder

6

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28 July 2017

Norman Wang

8

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28 July 2017

Aldo Amatucci

9

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28 July 2017

Jennifer S Michaelson

10

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28 July 2017

Scott M Glaser

11

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28 July 2017

language of work or name

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10 May 2010

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Protein Engineering Design and Selection

28 July 2017

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28 July 2017

23

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28 July 2017

549-557

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28 July 2017

7

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Novel tetravalent and bispecific IgG-like antibody molecules combining single-chain diabodies with the immunoglobulin gamma1 Fc or CH3 region

28 July 2017

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ028

A simple method for enriching populations of transfected CHO cells for cells of higher specific productivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ028

Selecting for antibody scFv fragments with improved stability using phage display with denaturation under reducing conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ028

CHARMM: A program for macromolecular energy, minimization, and dynamics calculations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ028

A graph-theory algorithm for rapid protein side-chain prediction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ028

Design and production of novel tetravalent bispecific antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ028

Optimization of the antibody C(H)3 domain by residue frequency analysis of IgG sequences.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ028

Engineering stability into Escherichia coli secreted Fabs leads to increased functional expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ028

Biophysical properties of human antibody variable domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ028

Clinical genetics for the pulmonologist: introduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ028

A broad range of Fab stabilities within a host of therapeutic IgGs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ028

A comparison of strategies to stabilize immunoglobulin Fv-fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ028

Directed evolution of an anti-carcinoembryonic antigen scFv with a 4-day monovalent dissociation half-time at 37 degrees C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ028

Structural energetics of the molten globule state

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ028

Engineered antibody fragments and the rise of single domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ028

The influence of the framework core residues on the biophysical properties of immunoglobulin heavy chain variable domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ028

Structural understanding of stabilization patterns in engineered bispecific Ig-like antibody molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ028

Recombinant bispecific antibodies for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ028

A fully human recombinant IgG-like bispecific antibody to both the epidermal growth factor receptor and the insulin-like growth factor receptor for enhanced antitumor activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ028

Recombinant approaches to IgG-like bispecific antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ028

Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTbetaR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ028

Rapid screening platform for stabilization of scFvs in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ028

Denaturant m values and heat capacity changes: relation to changes in accessible surface areas of protein unfolding

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ028

Engineering antibody Fv fragments for cancer detection and therapy: disulfide-stabilized Fv fragments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ028

Comparative protein modelling by satisfaction of spatial restraints

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ028

Directed evolution of a stable scaffold for T-cell receptor engineering.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ028

Conserved amino acid networks involved in antibody variable domain interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ028

Stability engineering of antibody single-chain Fv fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ028

21 January 2018

Identifiers

DOI

10.1093/PROTEIN/GZQ028

1 reference

28 July 2017

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