Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function (Q33569852)

28 July 2017

Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function (English)

1 reference

28 July 2017

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6

Ulrich H von Andrian

1 reference

28 July 2017

Arturo Borzutzky

4

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author name string

Lalit Kumar

1

1 reference

28 July 2017

Janet Chou

2

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28 July 2017

Christina S K Yee

3

1 reference

28 July 2017

Elisabeth H Vollmann

5

1 reference

28 July 2017

Shin-Young Park

7

1 reference

28 July 2017

Georg Hollander

8

1 reference

28 July 2017

John P Manis

9

1 reference

28 July 2017

P Luigi Poliani

10

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28 July 2017

Raif S Geha

11

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28 July 2017

language of work or name

English

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publication date

21 April 2014

1 reference

Journal of Experimental Medicine

28 July 2017

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28 July 2017

211

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28 July 2017

5

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28 July 2017

929-942

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PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors

28 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

An early T cell lineage commitment checkpoint dependent on the transcription factor Bcl11b

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

Non-redundant roles of the Gab1 and Gab2 scaffolding adapters in VEGF-mediated signalling, migration, and survival of endothelial cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

Cytokines, leptin, and stress-induced thymic atrophy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

Distinct roles for Syk and ZAP-70 during early thymocyte development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

Signaling pathways downstream of pattern-recognition receptors and their cross talk

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

3BP2 deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

NOD-LRR proteins: role in host-microbial interactions and inflammatory disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

Mutation in the leucine-rich repeat C-flanking region of platelet glycoprotein Ib beta impairs assembly of von Willebrand factor receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

Peripheral development of B cells in mouse and man.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

A congenital mutation of the novel gene LRRC8 causes agammaglobulinemia in humans

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

Genes required for B cell development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

Bcl11b is required for differentiation and survival of αβ T lymphocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

The "Gab" in signal transduction.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

Analysis of thymic stromal cell populations using flow cytometry

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

The Nrarp gene encodes an ankyrin-repeat protein that is transcriptionally regulated by the notch signaling pathway

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

The leucine-rich repeat as a protein recognition motif

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

Nrarp is a novel intracellular component of the Notch signaling pathway

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

A yeast two-hybrid study of human p97/Gab2 interactions with its SH2 domain-containing binding partners

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

A new mathematical model for relative quantification in real-time RT-PCR

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

Correlating notch signaling with thymocyte maturation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

The Syk family of protein tyrosine kinases in T-cell activation and development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

Sublethal gamma-radiation induces differentiation of CD4-/CD8- into CD4+/CD8+ thymocytes without T cell receptor beta rearrangement in recombinase activation gene 2-/- mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

Glucocorticoid-induced apoptosis in the thymus

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

LRRC8 proteins share a common ancestor with pannexins, and may form hexameric channels involved in cell-cell communication.

21 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1084%2FJEM.20131379

Biochemical and kinetic characterization of the glucocorticoid-induced apoptosis of immature CD4+CD8+ thymocytes.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1084%2FJEM.20131379

LRRC8 extracellular domain is composed of 17 leucine-rich repeats.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1084%2FJEM.20131379

The trophic action of IL-7 on pro-T cells: inhibition of apoptosis of pro-T1, -T2, and -T3 cells correlates with Bcl-2 and Bax levels and is independent of Fas and p53 pathways.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010910

Heterogeneity among DN1 prothymocytes reveals multiple progenitors with different capacities to generate T cell and non-T cell lineages

31 October 2018

1 reference

12 December 2020

Circulating hematopoietic progenitors with T lineage potential

1 reference

12 December 2020

Steroid sensitivity of thymocyte subpopulations during intrathymic differentiation. Effects of 17 beta-estradiol and dexamethasone on subsets expressing T cell antigen receptor or IL-2 receptor

1 reference

12 December 2020

A defect in the nuclear translocation of CIITA causes a form of type II bare lymphocyte syndrome

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20131379

1 reference

release_mzkzuchhqnapbophnafppgpw5u

28 July 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/mzkzuchhqnapbophnafppgpw5u

24 November 2022

mapped directly with Wikidata item

PMCID

4010910

1 reference

28 July 2017

1 reference