Physiological modeling to understand the impact of enzymes and transporters on drug and metabolite data and bioavailability estimates (Q33550408)

28 July 2017

Physiological modeling to understand the impact of enzymes and transporters on drug and metabolite data and bioavailability estimates (English)

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28 July 2017

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Huadong Sun

1

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28 July 2017

K Sandy Pang

series ordinal

2

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28 July 2017

language of work or name

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6 April 2010

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28 July 2017

Pharmaceutical Research

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28 July 2017

27

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28 July 2017

7

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28 July 2017

1237-1254

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Bioavailability of drugs (first of two parts).

28 July 2017

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https://api.crossref.org/works/10.1007%2FS11095-010-0049-2

Bioavailability of drugs (second of two parts).

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11095-010-0049-2

An in vitro examination of the impact of polyethylene glycol 400, Pluronic P85, and vitamin E d-alpha-tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein efflux and enterocyte-based metabolism in excised rat intestine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-010-0049-2

Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-010-0049-2

The role of metabolites in bioequivalence

21 January 2018

1 reference

12 December 2020

Fundamental relationships between the composition of pluronic block copolymers and their hypersensitization effect in MDR cancer cells

1 reference

12 December 2020

Sequential first-pass elimination of a metabolite derived from a precursor

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12 December 2020

An Overview of the Analysis and Interpretation of Bioavailability Studies in Man

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12 December 2020

Commonly used surfactant, Tween 80, improves absorption of P-glycoprotein substrate, digoxin, in rats

1 reference

12 December 2020

Effects of poly(ethylene glycol) on efflux transporter activity in Caco-2 cell monolayers

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12 December 2020

Effect of polyoxyl 35 castor oil and Polysorbate 80 on the intestinal absorption of digoxin in vitro

1 reference

12 December 2020

Pluronic block copolymers alter apoptotic signal transduction of doxorubicin in drug-resistant cancer cells

1 reference

12 December 2020

A general model of metabolite kinetics following intravenous and oral administration of the parent drug

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12 December 2020

An essential relationship between ATP depletion and chemosensitizing activity of Pluronic block copolymers.

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12 December 2020

Oral bioavailability and first-pass effects

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12 December 2020

Modulation of intestinal P-glycoprotein function by cremophor EL and other surfactants by an in vitro diffusion chamber method using the isolated rat intestinal membranes

1 reference

12 December 2020

A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P-glycoprotein activity in vitro

1 reference

12 December 2020

Area under the curve and bioavailability

1 reference

12 December 2020

Potential mechanisms by which Peceol increases the gastrointestinal absorption of amphotericin B.

1 reference

12 December 2020

Impact of Solutol HS 15 on the pharmacokinetic behaviour of colchicine upon intravenous administration to male Wistar rats

1 reference

12 December 2020

The role of metabolites in bioequivalency assessment. III. Highly variable drugs with linear kinetics and first-pass effect

1 reference

12 December 2020

Influence of route of administration on drug availability

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12 December 2020

N-trimethyl chitosan chloride as a potential absorption enhancer across mucosal surfaces: in vitro evaluation in intestinal epithelial cells (Caco-2).

1 reference

12 December 2020

Effect of excipients on the stability and transport of recombinant human epidermal growth factor (rhEGF) across CACO-2 cell monolayers

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12 December 2020

Impact of excipients on the absorption of P-glycoprotein substrates in vitro and in vivo

1 reference

12 December 2020

Identification of intestinal loss of a drug through physiologically based pharmacokinetic simulation of plasma concentration-time profiles

1 reference

12 December 2020

Experimental studies on the influence of surfactants on intestinal absorption of drugs. Cefadroxil as model drug and sodium lauryl sulfate as model surfactant: studies in rat colon.

1 reference

12 December 2020

Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration

1 reference

12 December 2020

Trimethylated chitosan as polymeric absorption enhancer for improved peroral delivery of peptide drugs

1 reference

12 December 2020

Disposition of nomifensine after acute and prolonged dosing

1 reference

12 December 2020

Physiological parameters in laboratory animals and humans

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12 December 2020

The role of metabolites in bioequivalency assessment. I. Linear pharmacokinetics without first-pass effect

1 reference

12 December 2020

Application of stable isotope methodology in the evaluation of the pharmacokinetics of (S,S)-3-[3-(methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride in rats

1 reference

12 December 2020

Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers

1 reference

12 December 2020

The role of metabolites in bioequivalency assessment. II. Drugs with linear pharmacokinetics and first-pass effect

1 reference

12 December 2020

Pharmacokinetics of lidocaine and its deethylated metabolite: dose and time dependency studies in man.

1 reference

12 December 2020

First-pass metabolism of lidocaine in the anesthetized rabbit. Contribution of the small intestine.

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12 December 2020

Effect of route of administration on drug disposition

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12 December 2020

Sequential first-pass metabolism of nortilidine: the active metabolite of the synthetic opioid drug tilidine

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12 December 2020

Disparity in intestine disposition between formed and preformed metabolites and implications: a theoretical study

1 reference

12 December 2020

Modeling of intestinal drug absorption: roles of transporters and metabolic enzymes (for the Gillette Review Series).

1 reference

12 December 2020

Pharmacokinetics of desethylamiodarone in the rat after its administration as the preformed metabolite, and after administration of amiodarone

1 reference

12 December 2020

Influence of vitamin E TPGS poly(ethylene glycol) chain length on apical efflux transporters in Caco-2 cell monolayers

1 reference

12 December 2020

Formed and preformed metabolites: facts and comparisons.

1 reference

12 December 2020

In vitro investigation on the impact of the surface-active excipients Cremophor EL, Tween 80 and Solutol HS 15 on the metabolism of midazolam

1 reference

12 December 2020

Hepatic blood flow in horses during the recuperative period from maximal exercise

1 reference

12 December 2020

Use of metabolite AUC data in bioavailability studies to discriminate between absorption and first-pass extraction

1 reference

12 December 2020

Pharmacokinetics of losartan, an angiotensin II receptor antagonist, and its active metabolite EXP3174 in humans

1 reference

12 December 2020

Modern bioavailability, bioequivalence and biopharmaceutics classification system. New scientific approaches to international regulatory standards

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12 December 2020

Metabolism of nomifensine after oral and intravenous administration

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12 December 2020

Enrofloxacin and marbofloxacin in horses: comparison of pharmacokinetic parameters, use of urinary and metabolite data to estimate first-pass effect and absorbed fraction

1 reference

12 December 2020

10.1007/S11095-010-0049-2

Identifiers

DOI

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release_cmt5nmft7jh4fgktqxhnx3gqua

28 July 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/cmt5nmft7jh4fgktqxhnx3gqua

24 November 2022

mapped directly with Wikidata item

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