The pathobiology of osteoarthritis and the rationale for the use of pentosan polysulfate for its treatment (Q33540394)

27 July 2017

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title

The pathobiology of osteoarthritis and the rationale for the use of pentosan polysulfate for its treatment (English)

1 reference

27 July 2017

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Ghosh P

1

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27 July 2017

1 February 1999

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Seminars in Arthritis and Rheumatism

27 July 2017

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27 July 2017

28

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27 July 2017

4

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27 July 2017

211-267

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The occurrence of osteoarthritis outside Europe

27 July 2017

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A longitudinal study of cartilage matrix metabolism in patients with cruciate ligament rupture--synovial fluid concentrations of aggrecan fragments, stromelysin-1 and tissue inhibitor of metalloproteinase-1.

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7 January 2021

Temporal patterns of stromelysin-1, tissue inhibitor, and proteoglycan fragments in human knee joint fluid after injury to the cruciate ligament or meniscus

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Connective tissue antigens stimulate collagenase production in arthritic diseases

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Cartilage specific collagen activates macrophages and the alternative pathway of complement: evidence for an immunopathogenic concept of rheumatoid arthritis

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Cellular immune response toward human articular chondrocytes. T cell reactivities against chondrocyte and fibroblast membranes in destructive joint diseases

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Antibodies to types I, II, IX, and XI collagen in the serum of patients with rheumatic diseases

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Experimental arthritis induced by intraarticular injection of allogenic cartilaginous particles into rabbit knees

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Evidence that a humoral immune response to autologous cartilage proteoglycan can participate in the induction of cartilage pathology

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Increased interleukin 1 beta production of macrophages by proteoglycan fragments deriving from articular cartilage in vitro

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Autoimmune recognition of cartilage collagens

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Immunolocalization of inducible nitric oxide synthase in synovium and cartilage in rheumatoid arthritis and osteoarthritis.

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Nitric oxide and proteoglycan biosynthesis by human articular chondrocytes in alginate culture

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Inflammatory cytokines and enzymes in synovial fluid of patients with rheumatoid arthritis and other arthritides

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Elevated synovial fluid levels of interleukin-6 and tumor necrosis factor associated with early experimental canine osteoarthritis

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Interleukin-1 beta induces synthesis and secretion of interleukin-6 in human chondrocytes

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Effects of interleukin-6 on the metabolism of connective tissue components in rheumatoid synovial fibroblasts

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Interleukin 6 enhances the production of tissue inhibitor of metalloproteinases (TIMP) but not that of matrix metalloproteinases by human fibroblasts

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The effect of additive hyaluronic acid on animal joints with experimentally reduced lubricating ability

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Increased friction of animal joints by experimental degeneration and recovery by addition of hyaluronic acid

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Concentration and molecular weight of sodium hyaluronate in synovial fluid from patients with rheumatoid arthritis and other arthropathies

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Osteoarthritis and hyaluronan--palliative or disease-modifying treatment?

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Interactions of hyaluronan (hyaluronic acid) with phospholipids as determined by gel permeation chromatography, multi-angle laser-light-scattering photometry and 1H-NMR spectroscopy

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Hyaluronan receptor (CD44) expression and function in human peripheral blood monocytes and alveolar macrophages

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https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

The synthesis of hyaluronic acid by human synovial fibroblasts is influenced by the nature of the hyaluronate in the extracellular environment

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Synovial intimal fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Synthesis of underpolymerized hyaluronic acid by fibroblasts cultured from rheumatoid and non-rheumatoid synovitis

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Pentosan polysulphate and glycosaminoglycan polysulphate stimulate the synthesis of hyaluronan in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Interactions of pentosan polysulfate with cartilage matrix proteins and synovial fibroblasts derived from patients with osteoarthritis

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Osteoarthritis of the hip: a study of the nature and evolution of the disease

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Intramedullary pressure of the patella in Chondromalacia

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Intraosseous Pressure in the Patella in Relation to Simulated Joint Effusion and Knee Position:An Experimental Study in Puppies

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Intraosseous pressure and partial pressures of oxygen and carbon dioxide in osteoarthritis

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Microvascular obstruction in avascular necrosis. Immunohistochemistry of 14 femoral heads.

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Mechanisms of inflammation and leukocyte activation

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Anti-P-selectin antibody decreases inflammation and thrombus formation in venous thrombosis

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Inflammation: They're not just for clots anymore

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Effect of Pentosan Polysulfate on Activated Partial Thromboplastin Time, Thrombin Time, Euglobulin Clot Lysis, and on Tissue-Type Plasminogen Activator and Plasminogen Activator Inhibitor Activities in Patients with Thromboembolic Disease

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Comparison of the effects of sodium pentosanpolysulfate and unfractionated heparin on venous thrombosis; an experimental study in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Platelets and inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

In vitro studies of the interaction of heparin, low molecular weight heparin and heparinoids with platelets

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Influence on the clotting mechanism of sodium pentosan polysulfate (SP54) in comparison to commercial beef lung sodium heparin

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Fibrinogen binding on human platelets. Influence of different heparins and of pentosane polysulfate

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Effects of a sulphated xylan on aggregation of human blood platelets

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Anticoagulant activities of a pentosane polysulphate: Comparison with standard heparin and a fraction of low molecular weight heparin

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Effect of sulfated xylans during the interaction of [125I]-thrombin with antithrombin III or heparin cofactor II of human plasma

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

In vivo release of anti-Xa clotting activity by a heparin analogue

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Studies on the different mechanisms by which heparin and polysulphated xylan (PZ 68) inhibit blood coagulation in man

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Pentosan polysulphate: activation of heparin cofactor II or antithrombin III according to molecular weight fractionation

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

The antiheparin effect of a heparinoid, pentosan polysulphate. Investigation of a mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Identification of heparin cofactor II as the principal plasma cofactor for the antithrombin activity of pentosan polysulphate (SP54)

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Kinetic Considerations on the Physiologic Control of Thrombin and Factor Xa

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Mechanisms for inhibition of the generation of thrombin activity by sulfated polysaccharides

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Inhibition of thrombin-induced platelet aggregation and serotonin release by antithrombin III and heparin cofactor II in the presence of standard heparin, dermatan sulfate and pentosan polysulfate

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Respective role of antithrombin III and heparin cofactor II in the in vitro anticoagulant effect of heparin and of various sulphated polysaccharides

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Effect of Pentosan Polysulfate on Fibrinolysis: Basic Tests and Clinical Application

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Comparison between the effect of pentosan polysulphate heparin and antithrombin III injections in antithrombin III deficient patients

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

The inhibition of thrombin-dependent positive-feedback reactions is critical to the expression of the anticoagulant effect of heparin

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Inhibition of coagulation and platelet adhesion to extracellular matrix by unfractionated heparin and a low molecular weight heparin

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Influence of heparin; of different heparin fractions and of a low molecular weight heparin-like substance on the mechanism of fibrinolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Effect of the heparinoid pentosan polysulphate (SP 54) on the functional properties of cultured bovine aortic endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Release of plasminogen activator by pentosan polysulphate

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

A comparison of the lipolytic and anticoagulative properties of heparin and pentosan polysulphate in the thoroughbred horse

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

The effects of post-heparin plasma lipases on anti-Xa clotting activity

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Use of anti-inflammatory and analgesic drugs in dogs and cats

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Systemic use of pentosan polysulphate in the treatment of osteoarthritis.

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

An enzyme-linked immunosorbent-inhibition assay for quantitation of hyaluronan (hyaluronic acid) in biological fluids

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Degradation of proteoglycan aggregate by a cartilage metalloproteinase. Evidence for the involvement of stromelysin in the generation of link protein heterogeneity in situ

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Matrix metalloproteinases cleave at two distinct sites on human cartilage link protein

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

ECM and cell surface proteolysis: regulating cellular ecology

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Degradation of type IX collagen by matrix metalloproteinase 3 (stromelysin) from human rheumatoid synovial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Activation of matrix metalloproteinase 3 (stromelysin) and matrix metalloproteinase 2 ('gelatinase') by human neutrophil elastase and cathepsin G

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Plasmin degradation of cartilage proteoglycan

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Recombinant human interleukin-1 stimulates human articular cartilage to undergo resorption and human chondrocytes to produce both tissue- and urokinase-type plasminogen activator

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Effects of tumor necrosis factor alpha and beta on resorption of human articular cartilage and production of plasminogen activator by human articular chondrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

The degradation of articular collagen by neutrophil proteinases

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Degradation of cartilage collagens type II, IX, X and XI by enzymes derived from human articular chondrocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Susceptibility of cartilage collagens type II, IX, X, and XI to human synovial collagenase and neutrophil elastase.

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Biotin-Labeled Potato Chymotrypsin Inhibitor-1: A Useful Probe for the Detection and Quantitation of Chymotrypsin-like Serine Proteinases on Western Blots and Its Application in the Detection of a Serine Proteinase Synthesized by Articular Chondrocyt

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Susceptibility of the cartilage collagens types II, IX and XI to degradation by the cysteine proteinases, cathepsins B and L

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Cathepsin B in osteoarthritis: zonal variation of enzyme activity in human femoral head cartilage

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Extracellular presence of the lysosomal proteinase cathepsin B in rheumatoid synovium and its activity at neutral pH

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Characterization of proteoglycan degradation by calpain

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

The hyaluronate receptor is a member of the CD44 (H-CAM) family of cell surface glycoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

Catabolism of Hyaluronan in the Knee Joint of the Rabbit

1 reference

https://api.crossref.org/works/10.1016%2FS0049-0172%2899%2980021-3

7 January 2021

10.1016/S0049-0172(99)80021-3

Identifiers

DOI

1 reference

27 July 2017

1 reference

PubMed ID

10073500