A semi-mechanistic model to predict the effects of liver cirrhosis on drug clearance (Q33532744)

27 July 2017

A semi-mechanistic model to predict the effects of liver cirrhosis on drug clearance (English)

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27 July 2017

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Trevor N Johnson

1

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27 July 2017

Koen Boussery

2

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27 July 2017

Karen Rowland-Yeo

3

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27 July 2017

Geoffrey T Tucker

4

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27 July 2017

Amin Rostami-Hodjegan

5

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27 July 2017

1 March 2010

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Clinical Pharmacokinetics

27 July 2017

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27 July 2017

49

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27 July 2017

3

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27 July 2017

189-206

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https://scigraph.springernature.com/pub.10.2165/11318160-000000000-00000

27 July 2017

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cites work

The metabolism and bioavailability of morphine in patients with severe liver cirrhosis

1 reference

https://api.crossref.org/works/10.2165%2F11318160-000000000-00000

Commentary: a physiological approach to hepatic drug clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318160-000000000-00000

Evaluation of liver functional reserve by combining D-sorbitol clearance rate and CT measured liver volume

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318160-000000000-00000

CYP3A4 and CYP2A6 activities marked by the metabolism of lignocaine and coumarin in patients with liver and kidney diseases and epileptic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318160-000000000-00000

The metabolism of 7-ethoxycoumarin in human liver microsomes and the effect of primary biliary cirrhosis: implications for studies of drug metabolism in liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318160-000000000-00000

Different alterations of cytochrome P450 3A4 isoform and its gene expression in livers of patients with chronic liver diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318160-000000000-00000

Severity of cirrhosis and the relationship of alpha 1-acid glycoprotein concentration to plasma protein binding of lidocaine.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318160-000000000-00000

Reduction in renal blood flow following acute increase in the portal pressure: evidence for the existence of a hepatorenal reflex in man?

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318160-000000000-00000

Hepatic perfusion parameters in chronic liver disease: dynamic CT measurements correlated with disease severity

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318160-000000000-00000

Hepatic artery hemodynamic responsiveness to altered portal blood flow in normal and cirrhotic livers.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318160-000000000-00000

Doppler study of hepatic vein in cirrhotic patients: correlation with liver dysfunction and hepatic hemodynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318160-000000000-00000

Portosystemic shunting in portal hypertension: evaluation with portal scintigraphy with transrectally administered I-123 IMP

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318160-000000000-00000

The pharmacokinetics of caffeine and its dimethylxanthine metabolites in patients with chronic liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318160-000000000-00000

Pharmacokinetics of midazolam following intravenous and oral administration in patients with chronic liver disease and in healthy subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318160-000000000-00000

Creatinine clearance: an inadequate marker of renal filtration in patients with early posthepatitic cirrhosis (Child A) without fluid retention and muscle wasting

21 January 2018

1 reference

12 December 2020

Glomerular filtration rate measurement in cirrhotic patients with renal failure

1 reference

12 December 2020

Reduced duodenal cytochrome P450 3A protein expression and catalytic activity in patients with cirrhosis

1 reference

12 December 2020

Pharmacokinetics of chlormethiazole in healthy volunteers and patients with cirrhosis of the liver

1 reference

12 December 2020

Pharmacokinetics of omeprazole in cirrhotic patients

1 reference

12 December 2020

Liver volume in patients with or without chronic liver diseases

1 reference

12 December 2020

Quinidine pharmacokinetics in patients with cirrhosis or receiving propranolol

1 reference

12 December 2020

Circulatory changes in chronic liver disease

1 reference

12 December 2020

Pharmacokinetics of nifedipine after oral administration in chronic liver disease

1 reference

12 December 2020

Prediction of in vivo drug clearance from in vitro data. I: impact of inter-individual variability

1 reference

12 December 2020

Effects of liver disease on pharmacokinetics. An update

1 reference

12 December 2020

The human intestinal cytochrome P450 "pie".

1 reference

12 December 2020

Prediction of GFR in liver transplant candidates

1 reference

12 December 2020

Cardiac output determined by echocardiography in patients with cirrhosis: comparison with the indicator dilution technique

1 reference

12 December 2020

Biliary excretion of intravenous [14C] omeprazole in humans

1 reference

12 December 2020

Splanchnic and extrasplanchnic arterial hemodynamics in patients with cirrhosis

1 reference

12 December 2020

Hepatic and intestinal cytochrome P450 3A activity in cirrhosis: effects of transjugular intrahepatic portosystemic shunts

1 reference

12 December 2020

Intestinal first pass metabolism of midazolam in liver cirrhosis --effect of grapefruit juice

1 reference

12 December 2020

Normal red cell cardiac output in the hyperkinetic syndrome of alcoholic cirrhosis

1 reference

12 December 2020

Theophylline metabolism in patients with hepatosplenic mansoniasis and cirrhosis

1 reference

12 December 2020

A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: A tale of 'bottom-up' vs 'top-down' recogn

1 reference

12 December 2020

Theophylline pharmacokinetics and liver function indexes in chronic liver disease

1 reference

12 December 2020

Impairment of albumin and whole body postprandial protein synthesis in compensated liver cirrhosis

1 reference

12 December 2020

Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors

1 reference

12 December 2020

The portal component of hepatic perfusion measured by dynamic CT: an indicator of hepatic parenchymal damage

1 reference

12 December 2020

The hepatic sinusoid in aging and cirrhosis: effects on hepatic substrate disposition and drug clearance.

1 reference

12 December 2020

Renal function in cirrhosis and the effects of prostaglandin A1

1 reference

12 December 2020

Comparison of human duodenum and Caco-2 gene expression profiles for 12,000 gene sequences tags and correlation with permeability of 26 drugs

1 reference

12 December 2020

Volumetric and functional liver blood flow are both increased in the human transplanted liver

1 reference

12 December 2020

Liver disease selectively modulates cytochrome P450--mediated metabolism

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of intravenous midazolam in patients with severe alcoholic cirrhosis

1 reference

12 December 2020

Portal Blood Flow in Cirrhosis of the Liver*

1 reference

12 December 2020

Nutrition and survival in patients with liver cirrhosis

1 reference

12 December 2020

Cytochrome P450 1A2 is a major determinant of lidocaine metabolism in vivo: effects of liver function

1 reference

12 December 2020

Pharmacokinetics of diclofenac sodium in chronic active hepatitis and alcoholic cirrhosis

1 reference

12 December 2020

Differential alterations of cytochrome P450 proteins in livers from patients with severe chronic liver disease

1 reference

12 December 2020

Functional hepatic flow in patients with liver cirrhosis

1 reference

12 December 2020

Prediction of in vivo drug clearance from in vitro data. II: potential inter-ethnic differences

1 reference

12 December 2020

Changes of portal venous flow velocity after liver transplantation and its causes

1 reference

12 December 2020

Validity of the 13C-caffeine breath test as a noninvasive, quantitative test of liver function

1 reference

12 December 2020

Glucuronidation of drugs by hepatic microsomes derived from healthy and cirrhotic human livers

1 reference

12 December 2020

Change in portal flow after liver transplantation: effect on hepatic arterial resistance indices and role of spleen size.

1 reference

12 December 2020

Evaluation of hepatic function in liver cirrhosis: clinical utility of galactose elimination capacity, hepatic clearance of D-sorbitol, and laboratory investigations

1 reference

12 December 2020

Antiarrhythmics: elimination and dosage considerations in hepatic impairment

1 reference

12 December 2020

In-vivo indices of enzyme activity: the effect of renal impairment on the assessment of CYP2D6 activity

1 reference

12 December 2020

Renal functional reserve and nitric oxide in patients with compensated liver cirrhosis

1 reference

12 December 2020

Portal and splenic hemodynamics in cirrhotic patients: relationship between esophageal variceal bleeding and the severity of hepatic failure

1 reference

12 December 2020

Liver cirrhosis mortality rates in Britain from 1950 to 2002: an analysis of routine data

1 reference

12 December 2020

Changes in liver volume from birth to adulthood: a meta-analysis.

1 reference

12 December 2020

Functional hepatic volume measured by technetium-99m-galactosyl-human serum albumin liver scintigraphy: comparison between hepatocyte volume and liver volume by computed tomography

1 reference

12 December 2020

Pharmacokinetics of omeprazole given by continuous intravenous infusion to patients with varying degrees of hepatic dysfunction

1 reference

12 December 2020

Hepatic flow parameters measured with MR imaging and Doppler US: correlations with degree of cirrhosis and portal hypertension.

1 reference

12 December 2020

Impaired elimination of caffeine in cirrhosis

1 reference

12 December 2020

New challenge of hepatorenal syndrome: prevention and treatment

1 reference

12 December 2020

Receptor measurements via Tc-GSA kinetic modeling are proportional to functional hepatocellular mass

1 reference

12 December 2020

The creatinine approach to estimate skeletal muscle mass in patients with cirrhosis

1 reference

12 December 2020

Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children

1 reference

12 December 2020

Pharmacokinetics and dosage adjustment in patients with hepatic dysfunction

1 reference

12 December 2020

Prediction of intestinal first-pass drug metabolism

1 reference

12 December 2020

'In silico' simulations to assess the 'in vivo' consequences of 'in vitro' metabolic drug-drug interactions

1 reference

12 December 2020

Transection of the oesophagus for bleeding oesophageal varices

1 reference

12 December 2020

Nutritional assessment in various stages of liver cirrhosis.

1 reference

12 December 2020

The effects of age and renal and hepatic impairment on the pharmacokinetics of sildenafil

1 reference

12 December 2020

Distribution of mesenteric and splenic blood flow in cirrhosis of the liver as estimated by radionuclide angiography

1 reference

12 December 2020

Hemorheology in patients with liver cirrhosis: special emphasis on its relation to severity of esophageal variceal bleeding

1 reference

12 December 2020

Functional liver imaging with 99 Tcm-galactosyl-neoglycoalbumin (NGA) in alcoholic liver cirrhosis and liver fibrosis

1 reference

12 December 2020

Assessment of portosystemic shunting from superior mesenteric vein by duodenal administration of iodoamphetamine I123

1 reference

12 December 2020

The pharmacokinetics of theophylline and enprofylline in patients with liver cirrhosis and in patients with chronic renal disease

1 reference

12 December 2020

Clinical pharmacokinetics in patients with liver disease

1 reference

12 December 2020

Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples

1 reference

12 December 2020

Pharmacokinetics of [14C]omeprazole in patients with liver cirrhosis

1 reference

12 December 2020

The cardiac response to exercise in cirrhosis

1 reference

12 December 2020

Portal venous hemodynamics in chronic liver disease: effects of posture change and exercise

1 reference

12 December 2020

Selective effect of liver disease on the activities of specific metabolizing enzymes: investigation of cytochromes P450 2C19 and 2D6.

1 reference

12 December 2020

Hepatocyte volume as an indicator of hepatic functional reserve in cirrhotic patients with liver tumours

1 reference

12 December 2020

The Simcyp population-based ADME simulator

1 reference

12 December 2020

In vivo metabolic activity of CYP2C19 and CYP3A in relation to CYP2C19 genetic polymorphism in chronic liver disease

1 reference

12 December 2020

GENERAL AND REGIONAL CIRCULATORY ALTERATIONS IN CIRRHOSIS OF THE LIVER.

1 reference

12 December 2020

Pharmacokinetics of Metoprolol in Patients with Hepatic Cirrhosis

1 reference

12 December 2020

Interindividual variability in the concentrations of albumin and alpha-1-acid glycoprotein in patients with renal or liver disease, newborns and healthy subjects: implications for binding of drugs

1 reference

12 December 2020

Renal functional reserve is well maintained in patients with advanced liver cirrhosis and ascites

1 reference

12 December 2020

Pharmacokinetics of omeprazole in patients with liver cirrhosis and extrahepatic portal venous obstruction.

1 reference

12 December 2020

Renal hemodynamic and natriuretic effects of human atrial natriuretic factor infusion in cirrhosis with ascites

1 reference

12 December 2020

Physiology-based simulations of a pathological condition: prediction of pharmacokinetics in patients with liver cirrhosis

1 reference

12 December 2020

Correlation of serum concentrations of cystatin C and creatinine to inulin clearance in liver cirrhosis

1 reference

12 December 2020

Relationships between hemodynamic alterations and Child-Pugh Score in patients with cirrhosis.

1 reference

12 December 2020

Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.

1 reference

12 December 2020

Caffeine clearance in cirrhosis. The value of simplified determinations of liver metabolic capacity

1 reference

12 December 2020

Pre-translational regulation of cytochrome P450 genes is responsible for disease-specific changes of individual P450 enzymes among patients with cirrhosis.

1 reference

12 December 2020

Diagnostic value of plasma cystatin C as a glomerular filtration marker in decompensated liver cirrhosis

1 reference

12 December 2020

UDP glucuronosyltransferase mRNA levels in human liver disease

1 reference

12 December 2020

Effect of hepatic impairment on the pharmacokinetics of atomoxetine and its metabolites

1 reference

12 December 2020

Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

1 reference

12 December 2020

10.2165/11318160-000000000-00000

Identifiers

DOI

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Dimensions Publication ID

27 July 2017

1021670672

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Fatcat ID

release_2tbmdqb7irhbzckubs5k7ozn24

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Fatcat

https://api.fatcat.wiki/v0/release/2tbmdqb7irhbzckubs5k7ozn24

24 November 2022

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