Conditional inactivation of Brca1, p53 and Rb in mouse ovaries results in the development of leiomyosarcomas (Q33521701)

27 July 2017

Conditional inactivation of Brca1, p53 and Rb in mouse ovaries results in the development of leiomyosarcomas (English)

1 reference

27 July 2017

Katherine V Clark-Knowles

1

1 reference

27 July 2017

Mary K Senterman

2

1 reference

27 July 2017

Olga Collins

3

1 reference

27 July 2017

Barbara C Vanderhyden

4

1 reference

27 July 2017

language of work or name

English

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publication date

31 December 2009

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27 July 2017

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27 July 2017

4

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27 July 2017

12

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27 July 2017

e8534

1 reference

Creative Commons Attribution 4.0 International

27 July 2017

start time

31 December 2009

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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High rates of occult fallopian tube cancer diagnosed at prophylactic bilateral salpingo-oophorectomy

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Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer

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Brca1-deficient murine mammary epithelial cells have increased sensitivity to CDDP and MMS.

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Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2

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Lack of proliferative activity of surface epithelial inclusion cysts of the ovary.

21 June 2018

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Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform

21 June 2018

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21 June 2018

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Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding

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Caretaker Brca1: keeping the genome in the straight and narrow

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Accumulation of p53 protein is frequent in ovarian cancers associated with BRCA1 and BRCA2 germline mutations

21 June 2018

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BRCA1-associated growth arrest is RB-dependent

21 June 2018

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Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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A BRCA1 mutant alters G2-M cell cycle control in human mammary epithelial cells.

21 June 2018

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E-cadherin expression in human epithelial ovarian cancer and normal ovary

21 June 2018

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Double indemnity: p53, BRCA and cancer. p53 mutation partially rescues developmental arrest in Brca1 and Brca2 null mice, suggesting a role for familial breast cancer genes in DNA damage repair.

21 June 2018

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Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation.

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 June 2018

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21 June 2018

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Regulation of BRCA1 expression by the Rb-E2F pathway.

21 January 2018

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Conditional inactivation of Brca1 in the mouse ovarian surface epithelium results in an increase in preneoplastic changes.

21 January 2018

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Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

21 January 2018

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Apoptotic and cell cycle regulatory markers in uterine leiomyosarcoma.

21 January 2018

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Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer

21 January 2018

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MMTV-trBrca1 mice display strain-dependent abnormalities in vaginal development.

21 January 2018

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Strain-dependent differences in malignant conversion of mouse skin tumors is an inherent property of the epidermal keratinocyte

21 January 2018

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Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis.

21 January 2018

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17beta-estradiol accelerates tumor onset and decreases survival in a transgenic mouse model of ovarian cancer

21 January 2018

1 reference

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BRCA1 and BRCA2 mutations account for a large proportion of ovarian carcinoma cases

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795167

Clinical and pathologic findings of prophylactic salpingo-oophorectomies in 159 BRCA1 and BRCA2 carriers.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795167

Induction of carcinogenesis by concurrent inactivation of p53 and Rb1 in the mouse ovarian surface epithelium.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795167

Frequent loss of BRCA1 mRNA and protein expression in sporadic ovarian cancers

31 October 2018

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12 December 2020

Tumorigenesis as a consequence of genetic instability in Brca1 mutant mice

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12 December 2020

Frequency of BRCA1 dysfunction in ovarian cancer

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12 December 2020

Prophylactic oophorectomy: a morphologic and immunohistochemical study

1 reference

12 December 2020

Frequency of germline and somatic BRCA1 mutations in ovarian cancer

1 reference

12 December 2020

Mammary tumor formation in p53- and BRCA1-deficient mice

1 reference

12 December 2020

Altered surface and cyst epithelium of ovaries removed prophylactically from women with a family history of ovarian cancer

1 reference

12 December 2020

BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway

1 reference

12 December 2020

Increased frequency ofTP53 mutations inBRCA1 andBRCA2 ovarian tumours

1 reference

12 December 2020

p53 alterations in uterine leiomyosarcomas versus leiomyomas

1 reference

12 December 2020

Microscopic benign and invasive malignant neoplasms and a cancer-prone phenotype in prophylactic oophorectomies

1 reference

12 December 2020

Primary ovarian sarcoma: analysis of prognostic variables and the role of surgical cytoreduction

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12 December 2020

The biology of ovarian cancer

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0008534

Identifiers

DOI

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27 July 2017

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27 July 2017

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