Two Galpha(i1) rate-modifying mutations act in concert to allow receptor-independent, steady-state measurements of RGS protein activity (Q33509780)

27 July 2017

Two Galpha(i1) rate-modifying mutations act in concert to allow receptor-independent, steady-state measurements of RGS protein activity (English)

1 reference

27 July 2017

David P Siderovski

5

0 references

Adam Kimple

1 reference

ORCID Public Data File 2021

author name string

Thomas Zielinski

1

1 reference

27 July 2017

Adam J Kimple

2

1 reference

27 July 2017

Stephanie Q Hutsell

3

1 reference

27 July 2017

Mark D Koeff

4

1 reference

27 July 2017

Robert G Lowery

6

1 reference

27 July 2017

1 December 2009

1 reference

Journal of Biomolecular Screening

27 July 2017

1 reference

27 July 2017

14

1 reference

27 July 2017

10

1 reference

27 July 2017

1195-1206

1 reference

Characterization and optimization of a red-shifted fluorescence polarization ADP detection assay

27 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795102

Structural diversity in the RGS domain and its interaction with heterotrimeric G protein -subunits

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795102

The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Galpha-interaction face

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795102

Development of a Transcreener kinase assay for protein kinase A and demonstration of concordance of data with a filter-binding assay format

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795102

Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795102

Minimal determinants for binding activated G alpha from the structure of a G alpha(i1)-peptide dimer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795102

Transcreener: screening enzymes involved in covalent regulation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795102

G-protein signaling: back to the future

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795102

RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795102

Purification and in vitro functional analysis of the Arabidopsis thaliana regulator of G-protein signaling-1.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795102

Fluorescence-based assays for RGS box function

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795102

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795102

Regulators of G-protein signalling as new central nervous system drug targets.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795102

Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795102

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795102

Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795102

Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795102

The A326S mutant of Gialpha1 as an approximation of the receptor-bound state

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795102

RGS2/G0S8 is a selective inhibitor of Gqalpha function

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795102

Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795102

GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795102

A new family of regulators of G-protein-coupled receptors?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795102

Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795102

EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795102

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795102

GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795102

G proteins: transducers of receptor-generated signals

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795102

The influence of bound GDP on the kinetics of guanine nucleotide binding to G proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795102

A direct fluorescence-based assay for RGS domain GTPase accelerating activity

21 June 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109347473

Significance of Thr182 in the nucleotide-exchange and GTP-hydrolysis reactions of the alpha subunit of GTP-binding protein Gi2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109347473

Rapid activation of transducin by mutations distant from the nucleotide-binding site: evidence for a mechanistic model of receptor-catalyzed nucleotide exchange by G proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109347473

Evaluating PI3 kinase isoforms using Transcreener ADP assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057109347473

Covalent immobilization of histidine-tagged proteins for surface plasmon resonance

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19820068

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Discovery of acetyl-coenzyme A carboxylase 2 inhibitors: comparison of a fluorescence intensity-based phosphate assay and a fluorescence polarization-based ADP Assay for high-throughput screening

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19820068

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Quantitative assays for GTPase-activating proteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19820068

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1177/1087057109347473

1 reference

27 July 2017

1 reference

27 July 2017

1 reference