Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10 (Q33498106)

27 July 2017

Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10 (English)

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27 July 2017

Grace R Jeschke

2

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Cristina I Caescu

object named as

Cristina I Caescu

series ordinal

1

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author name string

Benjamin E Turk

series ordinal

3

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PubMed ID

19715556

27 July 2017

language of work or name

English

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publication date

23 October 2009

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27 July 2017

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27 July 2017

424

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27 July 2017

79-88

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27 July 2017

1

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ADAMs 10 and 17 represent differentially regulated components of a general shedding machinery for membrane proteins such as transforming growth factor alpha, L-selectin, and tumor necrosis factor alpha

27 July 2017

1 reference

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Formation of Pmel17 amyloid is regulated by juxtamembrane metalloproteinase cleavage, and the resulting C-terminal fragment is a substrate for gamma-secretase

14 July 2018

1 reference

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Metalloproteinase- and gamma-secretase-mediated cleavage of protein-tyrosine phosphatase receptor type Z

14 July 2018

1 reference

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Drug insight: tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis

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The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10.

14 July 2018

1 reference

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Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx

14 July 2018

1 reference

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ErbB-4 and TNF-alpha converting enzyme localization to membrane microdomains

14 July 2018

1 reference

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The shedding activity of ADAM17 is sequestered in lipid rafts

14 July 2018

1 reference

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Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans

14 July 2018

1 reference

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Substrate specificity and novel selective inhibitors of TNF-alpha converting enzyme (TACE) from two-dimensional substrate mapping

14 July 2018

1 reference

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Shedding of collagen XVII ectodomain depends on plasma membrane microenvironment

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1 reference

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ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.

14 July 2018

1 reference

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Evaluation of the contribution of different ADAMs to tumor necrosis factor alpha (TNFalpha) shedding and of the function of the TNFalpha ectodomain in ensuring selective stimulated shedding by the TNFalpha convertase (TACE/ADAM17).

14 July 2018

1 reference

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Ectodomain shedding of the glycoprotein GP of Ebola virus

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Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency

14 July 2018

1 reference

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Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

14 July 2018

1 reference

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Substrate specificity and inducibility of TACE (tumour necrosis factor α-converting enzyme) revisited: the Ala-Val preference, and induced intrinsic activity

14 July 2018

1 reference

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The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase

14 July 2018

1 reference

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Biochemical properties and functions of membrane-anchored metalloprotease-disintegrin proteins (ADAMs)

14 July 2018

1 reference

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Metalloprotease-mediated GH receptor proteolysis and GHBP shedding. Determination of extracellular domain stem region cleavage site

14 July 2018

1 reference

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The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

14 July 2018

1 reference

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Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1

14 July 2018

1 reference

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The tumor necrosis factor-alpha converting enzyme (TACE): a unique metalloproteinase with highly defined substrate selectivity

14 July 2018

1 reference

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A continuous fluorimetric assay for tumor necrosis factor-alpha converting enzyme

14 July 2018

1 reference

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Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability

14 July 2018

1 reference

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Determination of protease cleavage site motifs using mixture-based oriented peptide libraries

14 July 2018

1 reference

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Recognition sequences and structural elements contribute to shedding susceptibility of membrane proteins.

14 July 2018

1 reference

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A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

14 July 2018

1 reference

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Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme

14 July 2018

1 reference

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Structural properties of matrix metalloproteinases

14 July 2018

1 reference

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Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme

14 July 2018

1 reference

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Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha

14 July 2018

1 reference

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A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

14 July 2018

1 reference

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Human matrix metalloproteinase specificity studies using collagen sequence-based synthetic peptides

14 July 2018

1 reference

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Understanding the P1' specificity of the matrix metalloproteinases: effect of S1' pocket mutations in matrilysin and stromelysin-1.

14 July 2018

1 reference

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Mutational analysis of the membrane-proximal cleavage site of L-selectin: relaxed sequence specificity surrounding the cleavage site

14 July 2018

1 reference

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Structural requirements regulate endoproteolytic release of the L-selectin (CD62L) adhesion receptor from the cell surface of leukocytes.

14 July 2018

1 reference

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Membrane proximal cleavage of L-selectin: identification of the cleavage site and a 6-kD transmembrane peptide fragment of L-selectin

14 July 2018

1 reference

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Serum transferrin receptor is a truncated form of tissue receptor

14 July 2018

1 reference

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A nonsecretable cell surface mutant of tumor necrosis factor (TNF) kills by cell-to-cell contact

14 July 2018

1 reference

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Cleavage of amyloid beta peptide during constitutive processing of its precursor

14 July 2018

1 reference

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Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening.

14 July 2018

1 reference

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Selective inhibition of ADAM metalloproteases as a novel approach for modulating ErbB pathways in cancer.

31 October 2018

1 reference

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ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death.

31 October 2018

1 reference

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Characterization of sequential N-cadherin cleavage by ADAM10 and PS1.

31 October 2018

1 reference

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Stabilization of the autoproteolysis of TNF-alpha converting enzyme (TACE) results in a novel crystal form suitable for structure-based drug design studies.

31 October 2018

1 reference

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Pulmonary hypoplasia in mice lacking tumor necrosis factor-alpha converting enzyme indicates an indispensable role for cell surface protein shedding during embryonic lung branching morphogenesis.

31 October 2018

1 reference

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31 October 2018

1 reference

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Structural requirements for inducible shedding of the p55 tumor necrosis factor receptor

31 October 2018

1 reference

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A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

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12 December 2020

The 97-kDa (LABD97) and 120-kDa (LAD-1) fragments of bullous pemphigoid antigen 180/type XVII collagen have different N-termini

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The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site

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Fluorimetric assays of proteolytic enzymes

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Length of the linking domain of human pro-tumor necrosis factor determines the cleavage processing

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Role of the Juxtamembrane Domains of the Transforming Growth Factor-α Precursor and the β-Amyloid Precursor Protein in Regulated Ectodomain Shedding

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An essential role for ectodomain shedding in mammalian development

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ADAMs: focus on the protease domain

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Identifiers

DOI

10.1042/BJ20090549

1 reference

27 July 2017

1 reference

27 July 2017

1 reference

PubMed ID

19715556