A quantitative high-throughput screen for modulators of IL-6 signaling: a model for interrogating biological networks using chemical libraries (Q33492390)

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English	A quantitative high-throughput screen for modulators of IL-6 signaling: a model for interrogating biological networks using chemical libraries	scientific article

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scholarly article

1 reference

Europe PubMed Central

27 July 2017

A quantitative high-throughput screen for modulators of IL-6 signaling: a model for interrogating biological networks using chemical libraries (English)

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Europe PubMed Central

27 July 2017

4

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Europe PubMed Central

27 July 2017

object named as

Ajit Jadhav

3

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Christopher P Austin

10

object named as

Christopher P Austin

1 reference

Europe PubMed Central

27 July 2017

7

object named as

Menghang Xia

1 reference

Europe PubMed Central

27 July 2017

6

object named as

Ryan MacArthur

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Europe PubMed Central

27 July 2017

author name string

Ronald L Johnson

1

1 reference

Europe PubMed Central

27 July 2017

Ruili Huang

2

1 reference

Europe PubMed Central

27 July 2017

Jennifer Wichterman

5

1 reference

Europe PubMed Central

27 July 2017

Kun Bi

8

1 reference

Europe PubMed Central

27 July 2017

John Printen

9

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Europe PubMed Central

27 July 2017

James Inglese

11

1 reference

Europe PubMed Central

27 July 2017

publication date

19 June 2009

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Europe PubMed Central

27 July 2017

Molecular BioSystems

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Europe PubMed Central

27 July 2017

5

1 reference

Europe PubMed Central

27 July 2017

9

1 reference

Europe PubMed Central

27 July 2017

1039-1050

1 reference

Europe PubMed Central

27 July 2017

A miniaturized glucocorticoid receptor translocation assay using enzymatic fragment complementation evaluated with qHTS.

1 reference

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Cellular LanthaScreen and beta-lactamase reporter assays for high-throughput screening of JAK2 inhibitors

1 reference

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HTS assays using a disease-relevant cell model for interrogating the MAP kinase pathway initiated by multiple receptors

1 reference

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Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening

1 reference

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Compound Management for Quantitative High-Throughput Screening

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2747079

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Fluorescence spectroscopic profiling of compound libraries

1 reference

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8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008), a novel janus kinase 2 inhibitor, increases chemotherapy sensitivity in human ovarian cancer cells

1 reference

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High-throughput screening assays for the identification of chemical probes

1 reference

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An improved beta-lactamase reporter assay: multiplexing with a cytotoxicity readout for enhanced accuracy of hit identification

1 reference

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21 June 2018

The IL-6/sIL-6R complex as a novel target for therapeutic approaches

1 reference

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1 reference

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SD-1029 inhibits signal transducer and activator of transcription 3 nuclear translocation

1 reference

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21 June 2018

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries

1 reference

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Nanoliter dispensing for uHTS using pin tools

1 reference

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Piezo- and solenoid valve-based liquid dispensing for miniaturized assays

1 reference

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Application of division arrest technology to cell-based HTS: comparison with frozen and fresh cells

1 reference

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A cell-based beta-lactamase reporter gene assay for the identification of inhibitors of hepatitis C virus replication

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A beta-lactamase-dependent Gal4-estrogen receptor beta transactivation assay for the ultra-high throughput screening of estrogen receptor beta agonists in a 3456-well format

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Protein tyrosine phosphatase 1B inhibition: opportunities and challenges

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Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells

1 reference

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Principles of interleukin (IL)-6-type cytokine signalling and its regulation

1 reference

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21 June 2018

IL-6 mediated activation of STAT3 bypasses Janus kinases in terminally differentiated B lineage cells

1 reference

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21 June 2018

A road map for those who don't know JAK-STAT

1 reference

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Overexpression of IL-6 but not IL-8 increases paclitaxel resistance of U-2OS human osteosarcoma cells

1 reference

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21 June 2018

Autocrine production of interleukin 6 causes multidrug resistance in breast cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2747079

21 June 2018

Interleukin-6 induces androgen responsiveness in prostate cancer cells through up-regulation of androgen receptor expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2747079

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CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2747079

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Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2747079

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STAT proteins and transcriptional responses to extracellular signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2747079

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Fusions to beta-lactamase as a reporter for gene expression in live mammalian cells

1 reference

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Loss of IL-6 receptor expression in cervical carcinoma cells inhibits autocrine IL-6 stimulation: abrogation of constitutive monocyte chemoattractant protein-1 production

1 reference

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

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Naphthyl ketones: a new class of Janus kinase 3 inhibitors

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Quantitation of transcription and clonal selection of single living cells with beta-lactamase as reporter

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Interleukin 1alpha and interleukin 6 promote the in vitro growth of both normal and neoplastic human cervical epithelial cells

1 reference

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Receptors for interleukin (IL)-10 and IL-6-type cytokines use similar signaling mechanisms for inducing transcription through IL-6 response elements

1 reference

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Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

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Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

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1 reference

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Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor

1 reference

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Emodin has a cytotoxic activity against human multiple myeloma as a Janus-activated kinase 2 inhibitor

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https://pubmed.ncbi.nlm.nih.gov/19668870

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1 reference

https://pubmed.ncbi.nlm.nih.gov/19668870

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Action of recombinant human interleukin 6, interleukin 1 beta and tumor necrosis factor alpha on the mRNA induction of acute-phase proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19668870

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Identifiers

10.1039/B902021G

1 reference

Europe PubMed Central

27 July 2017

1 reference

Europe PubMed Central

27 July 2017

1 reference

Europe PubMed Central

27 July 2017

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