Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy (Q33463679)

27 July 2017

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title

Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy (English)

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27 July 2017

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Martin R Tremblay

1

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27 July 2017

Michael Nesler

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2

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27 July 2017

Robin Weatherhead

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3

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27 July 2017

Alfredo C Castro

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4

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27 July 2017

language of work or name

English

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publication date

1 August 2009

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Expert Opinion on Therapeutic Patents

27 July 2017

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27 July 2017

19

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27 July 2017

8

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27 July 2017

1039-1056

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Gli and hedgehog in cancer: tumours, embryos and stem cells.

27 July 2017

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https://api.crossref.org/works/10.1517%2F13543770903008551

The Hedgehog response network: sensors, switches, and routers

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

The cell biology of Smo signalling and its relationships with GPCRs

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Hedgehog: functions and mechanisms

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Vertebrate Smoothened functions at the primary cilium

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Beta-arrestin-mediated localization of smoothened to the primary cilium

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Hedgehog signalling in cancer formation and maintenance

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Hedgehog and patched in neural development and disease

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Activating Smoothened mutations in sporadic basal-cell carcinoma

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

A frequent activated smoothened mutation in sporadic basal cell carcinomas

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Mutations in SUFU predispose to medulloblastoma

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Loss of suppressor-of-fused function promotes tumorigenesis.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Hedgehog signalling in prostate regeneration, neoplasia and metastasis

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

A paracrine requirement for hedgehog signalling in cancer

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Induction of osteogenic differentiation by hedgehog proteins.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Hedgehog signaling in small-cell lung cancer: frequent in vivo but a rare event in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903008551

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Potent inhibitors of the hedgehog signaling pathway.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Medicinal chemistry of target family-directed masterkeys

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

A small-molecule antagonist of the hedgehog signaling pathway.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903008551

Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Teratogen-mediated inhibition of target tissue response to Shh signaling.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903008551

Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Medulloblastoma growth inhibition by hedgehog pathway blockade

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Activation of the hedgehog pathway in advanced prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903008551

HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903008551

Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903008551

Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903008551

Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903008551

Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903008551

Structural analogues of smoothened intracellular loops as potent inhibitors of Hedgehog pathway and cancer cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903008551

Ligand identification for G-protein-coupled receptors: a lead generation perspective

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Are target-family-privileged substructures truly privileged?

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

A small molecule that binds Hedgehog and blocks its signaling in human cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903008551

Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903008551

10.1517/13543770903008551

21 January 2018

Identifiers

DOI

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27 July 2017

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