Defective endomitosis during megakaryopoiesis leads to thrombocytopenia in Fanca-/- mice (Q33417872)

26 July 2017

Defective endomitosis during megakaryopoiesis leads to thrombocytopenia in Fanca-/- mice (English)

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26 July 2017

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2

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4 June 2020

William Vainchenker

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4 June 2020

author name string

Patrycja Pawlikowska

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4 June 2020

Filippo Rosselli

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4 June 2020

Valeria Naim

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4 June 2020

language of work or name

English

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publication date

26 September 2014

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26 July 2017

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4 June 2020

volume

124

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4 June 2020

page(s)

3613-3623

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4 June 2020

issue

24

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describes a project that uses

4 June 2020

ImageJ

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11 June 2022

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Learning from a paradox: recent insights into Fanconi anaemia through studying mouse models

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Presence of a defect in karyokinesis during megakaryocyte endomitosis

21 June 2018

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Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells

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Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes.

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Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia

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Cytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cells

21 June 2018

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A senescence-like cell-cycle arrest occurs during megakaryocytic maturation: implications for physiological and pathological megakaryocytic proliferation

21 June 2018

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Expanded roles of the Fanconi anemia pathway in preserving genomic stability

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21 June 2018

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ATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage response

21 June 2018

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Fanca-/- hematopoietic stem cells demonstrate a mobilization defect which can be overcome by administration of the Rac inhibitor NSC23766.

21 June 2018

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The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities

21 June 2018

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Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy.

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Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signaling.

31 October 2018

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12 December 2020

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Identifiers

DOI

10.1182/BLOOD-2014-01-551457

1 reference

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4 June 2020

1 reference

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4 June 2020

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