Modulating G-protein coupled receptor/G-protein signal transduction by small molecules suggested by virtual screening (Q33360557)

26 July 2017

title

Modulating G-protein coupled receptor/G-protein signal transduction by small molecules suggested by virtual screening (English)

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G protein-coupled receptor

26 July 2017

main subject

0 references

1 reference

Garland R Marshall

4

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author name string

Christina M Taylor

series ordinal

1

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26 July 2017

Yaniv Barda

series ordinal

2

1 reference

26 July 2017

Oleg G Kisselev

series ordinal

3

1 reference

26 July 2017

language of work or name

English

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publication date

16 August 2008

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Journal of Medicinal Chemistry

26 July 2017

published in

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26 July 2017

volume

51

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26 July 2017

issue

17

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26 July 2017

page(s)

5297-5303

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High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

26 July 2017

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21 June 2018

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Defining the interface between the C-terminal fragment of alpha-transducin and photoactivated rhodopsin

21 June 2018

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21 June 2018

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21 June 2018

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Focused library design in GPCR projects on the example of 5-HT(2c) agonists: comparison of structure-based virtual screening with ligand-based search methods

21 June 2018

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Modeling flexible loops in the dark-adapted and activated states of rhodopsin, a prototypical G-protein-coupled receptor

21 June 2018

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Consensus scoring criteria for improving enrichment in virtual screening

21 June 2018

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Managing molecular diversity

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Mutation of the fourth cytoplasmic loop of rhodopsin affects binding of transducin and peptides derived from the carboxyl-terminal sequences of transducin alpha and gamma subunits.

21 June 2018

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The amino terminus of the fourth cytoplasmic loop of rhodopsin modulates rhodopsin-transducin interaction

21 June 2018

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21 June 2018

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Antagonists of the receptor-G protein interface block Gi-coupled signal transduction.

21 June 2018

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Light-activated rhodopsin induces structural binding motif in G protein alpha subunit

21 June 2018

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Reciprocal effects of an inhibitory factor on catalytic activity and noncatalytic cGMP binding sites of rod phosphodiesterase

21 June 2018

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21 June 2018

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Virtual screening of biogenic amine-binding G-protein coupled receptors: comparative evaluation of protein- and ligand-based virtual screening protocols

31 October 2018

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Effect of digitonin on the rhodopsin meta I-meta II equilibrium

31 October 2018

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Successful virtual screening for a submicromolar antagonist of the neurokinin-1 receptor based on a ligand-supported homology model

31 October 2018

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Role of the retinal hydrogen bond network in rhodopsin Schiff base stability and hydrolysis

31 October 2018

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Virtual screening using protein-ligand docking: avoiding artificial enrichment.

31 October 2018

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Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor: discovery of novel and potent D3 ligands through a hybrid pharmacophore- and structure-based database searching approach.

31 October 2018

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Comparative evaluation of 11 scoring functions for molecular docking

31 October 2018

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Protein-based virtual screening of chemical databases. II. Are homology models of G-Protein Coupled Receptors suitable targets?

31 October 2018

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31 October 2018

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Consensus scoring: A method for obtaining improved hit rates from docking databases of three-dimensional structures into proteins.

31 October 2018

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Cooperative binding of the retinal rod G-protein, transducin, to light-activated rhodopsin

31 October 2018

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Absorption Spectrum of Rhodopsin denatured with Acid

31 October 2018

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12 December 2020

Rhodopsin content in the outer segment membranes of bovine and frog retinal rods

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12 December 2020

NMR structure of a receptor-bound G-protein peptide

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12 December 2020

Efficient Interaction with a Receptor Requires a Specific Type of Prenyl Group on the G Protein γ Subunit

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12 December 2020

Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin

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12 December 2020

Transducin-alpha C-terminal peptide binding site consists of C-D and E-F loops of rhodopsin

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12 December 2020

Structure-based drug discovery using GPCR homology modeling: successful virtual screening for antagonists of the alpha1A adrenergic receptor

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12 December 2020

Rhodopsin-interacting surface of the transducin gamma subunit

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12 December 2020

Antidermatophyte activity of medicago extracts and contained saponins and their structure-activity relationships

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12 December 2020

Alternate binding mode of C-terminal phenethylamine analogs of G(t)alpha(340-350) to photoactivated rhodopsin

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12 December 2020

Modeling of the complex between transducin and photoactivated rhodopsin, a prototypical G-protein-coupled receptor

1 reference

12 December 2020

Identifiers

DOI

10.1021/JM800326Q

1 reference

26 July 2017

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26 July 2017

1 reference