The crystal structure of netrin-1 in complex with DCC reveals the bifunctionality of netrin-1 as a guidance cue. (Q33358945)

26 July 2017

The crystal structure of netrin-1 in complex with DCC reveals the bifunctionality of netrin-1 as a guidance cue. (English)

1 reference

26 July 2017

8

1 reference

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3 June 2020

Dmitri Svergun

9

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3 June 2020

Rob Meijers

12

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3 June 2020

author name string

Lorenzo I Finci

1

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3 June 2020

Nina Krüger

2

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3 June 2020

Xiaqin Sun

3

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3 June 2020

Jie Zhang

4

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3 June 2020

Magda Chegkazi

5

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3 June 2020

Yu Wu

6

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3 June 2020

Gundolf Schenk

7

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3 June 2020

Yan Zhang

10

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3 June 2020

Jia-Huai Wang

11

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3 June 2020

language of work or name

English

0 references

publication date

7 August 2014

1 reference

26 July 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25123307%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

volume

83

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3 June 2020

page(s)

839-849

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3 June 2020

issue

4

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New developments in the ATSAS program package for small-angle scattering data analysis

3 June 2020

cites work

1 reference

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Optimization of protein purification and characterization using Thermofluor screens

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412161

Structure of the Repulsive Guidance Molecule (RGM)-Neogenin Signaling Hub

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412161

N-terminal horseshoe conformation of DCC is functionally required for axon guidance and might be shared by other neural receptors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412161

Less than 5 Netrin-1 molecules initiate attraction but 200 Sema3A molecules are necessary for repulsion.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412161

Crystal Structures of the Network-Forming Short-Arm Tips of the Laminin β1 and γ1 Chains

21 June 2018

1 reference

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Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours

21 June 2018

1 reference

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Crystal Structure of the Ligand Binding Domain of Netrin G2

21 June 2018

1 reference

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Structural basis for cell surface patterning through NetrinG-NGL interactions

21 June 2018

1 reference

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Netrins: versatile extracellular cues with diverse functions

21 June 2018

1 reference

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Overview of the CCP4 suite and current developments

21 June 2018

1 reference

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Mechanisms and molecules of neuronal wiring: a primer

21 June 2018

1 reference

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The netrin protein family

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412161

Interfering with multimerization of netrin-1 receptors triggers tumor cell death.

21 June 2018

1 reference

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Autoinhibition of UNC5b revealed by the cytoplasmic domain structure of the receptor

21 June 2018

1 reference

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DSCAM functions as a netrin receptor in commissural axon pathfinding

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412161

Dscam guides embryonic axons by Netrin-dependent and -independent functions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412161

Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions

21 June 2018

1 reference

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DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412161

Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling

21 June 2018

1 reference

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Heparin-induced cis- and trans-Dimerization Modes of the Thrombospondin-1 N-terminal Domain

21 June 2018

1 reference

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Netrins promote developmental and therapeutic angiogenesis.

21 June 2018

1 reference

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Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine phosphorylation

21 June 2018

1 reference

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Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction

21 June 2018

1 reference

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Netrin-1 controls colorectal tumorigenesis by regulating apoptosis

21 June 2018

1 reference

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Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin

21 June 2018

1 reference

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Heparin-protein interactions

21 June 2018

1 reference

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Molecular mechanisms of axon guidance

21 June 2018

1 reference

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Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation

21 June 2018

1 reference

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A novel member of the netrin family, beta-netrin, shares homology with the beta chain of laminin: identification, expression, and functional characterization

21 June 2018

1 reference

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Calcium signalling in the guidance of nerve growth by netrin-1.

21 June 2018

1 reference

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A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion

21 June 2018

1 reference

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Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors

21 June 2018

1 reference

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Deleted in colorectal carcinoma (DCC) binds heparin via its fifth fibronectin type III domain

21 June 2018

1 reference

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Deleted in Colorectal Cancer (DCC) encodes a netrin receptor

21 June 2018

1 reference

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Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord

21 June 2018

1 reference

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The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412161

The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412161

A hot spot of binding energy in a hormone-receptor interface

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412161

Identification of a chromosome 18q gene that is altered in colorectal cancers

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412161

Pattern of invasion of the embryonic mouse spinal cord by microglial cells at the time of the onset of functional neuronal networks.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412161

Profiling the sulfation specificities of glycosaminoglycan interactions with growth factors and chemotactic proteins using microarrays

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412161

Neogenin interacts with RGMa and netrin-1 to guide axons within the embryonic vertebrate forebrain.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412161

Identification of domains of netrin UNC-6 that mediate attractive and repulsive guidance and responses from cells and growth cones

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25123307

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

DCC constrains tumour progression via its dependence receptor activity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25123307

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

DAMMIF, a program for rapid ab-initio shape determination in small-angle scattering

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25123307

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.NEURON.2014.07.010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25123307%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25123307%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

1 reference

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