Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: a mechanism sensitive to the Kunitz protease inhibitor (Q33358106)

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English	Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: a mechanism sensitive to the Kunitz protease inhibitor	scientific article

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scholarly article

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Europe PubMed Central

26 July 2017

Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: a mechanism sensitive to the Kunitz protease inhibitor (English)

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Europe PubMed Central

26 July 2017

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Frederico Ferreira-da-Silva

object named as

Frederico Ferreira-da-Silva

2

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object named as

Isabel Cardoso

4

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Maria João Saraiva

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Maria J Saraiva

3

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author name string

Rita Costa

1

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Europe PubMed Central

26 July 2017

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publication date

6 August 2008

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Europe PubMed Central

26 July 2017

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Europe PubMed Central

26 July 2017

3

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Europe PubMed Central

26 July 2017

8

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Europe PubMed Central

26 July 2017

e2899

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Europe PubMed Central

26 July 2017

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Creative Commons Attribution 4.0 International

6 August 2008

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April 2022 Public Data File from Crossref

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Amyloid beta-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin

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Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta

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Transthyretin binding to A-Beta peptide--impact on A-Beta fibrillogenesis and toxicity.

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21 June 2018

LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-beta peptide in a blood-brain barrier in vitro model

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21 June 2018

Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Abeta toxicity

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Differences in extracellular matrix production and basic fibroblast growth factor response in skin fibroblasts from sporadic and familial Alzheimer's disease

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A beta oligomers - a decade of discovery

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beta-Amyloid degradation and Alzheimer's disease

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Clearance of amyloid-beta in Alzheimer's disease: progress, problems and perspectives

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APP processing and the APP-KPI domain involvement in the amyloid cascade.

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Comparative proteomics of cerebrospinal fluid in neuropathologically-confirmed Alzheimer's disease and non-demented elderly subjects

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Proteolytic mechanisms in amyloid-beta metabolism: therapeutic implications for Alzheimer's disease

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Protein measurement with the Folin phenol reagent

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Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme

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Neurodegeneration: new clues on inclusions

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Medin: an integral fragment of aortic smooth muscle cell-produced lactadherin forms the most common human amyloid

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Translating cell biology into therapeutic advances in Alzheimer's disease

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A stop-codon mutation in the BRI gene associated with familial British dementia

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Binding of gelsolin, a secretory protein, to amyloid beta-protein

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21 June 2018

Cerebrospinal fluid transthyretin: aging and late onset Alzheimer's disease

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21 June 2018

Cell-specific expression of beta-amyloid precursor protein isoform mRNAs and proteins in neurons and astrocytes.

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21 June 2018

The alternatively spliced Kunitz protease inhibitor domain alters amyloid beta protein precursor processing and amyloid beta protein production in cultured cells.

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21 June 2018

Transthyretin gene in Alzheimer's disease patients.

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21 June 2018

Transthyretin sequesters amyloid beta protein and prevents amyloid formation

1 reference

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21 June 2018

Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans

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21 June 2018

Senile cerebral amyloid. Prealbumin as a common constituent in the neuritic plaque, in the neurofibrillary tangle, and in the microangiopathic lesion

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21 June 2018

The contribution of thyroxine-binding prealbumin to the binding of thyroxine in human serum, as assessed by immunoadsorption

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21 June 2018

Production of recombinant human transthyretin with biological activities toward the understanding of the molecular basis of familial amyloidotic polyneuropathy (FAP).

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21 June 2018

Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme.

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21 January 2018

Serum insulin-like growth factor I regulates brain amyloid-beta levels.

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Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis.

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21 January 2018

Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin).

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21 January 2018

Transthyretin, a new cryptic protease

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21 January 2018

ApoA-I cleaved by transthyretin has reduced ability to promote cholesterol efflux and increased amyloidogenicity.

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21 January 2018

LRP-mediated clearance of Abeta is inhibited by KPI-containing isoforms of APP.

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21 January 2018

Structural and kinetic features of amyloid beta-protein fibrillogenesis.

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Cholesterol metabolism and brain amyloidosis: evidence for a role of copper in the clearance of Abeta through the liver.

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21 January 2018

The amyloid beta-protein precursor of Alzheimer's disease is degraded extracellularly by a Kunitz protease inhibitor domain-sensitive trypsin-like serine protease in cultures of chick sympathetic neurons.

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21 January 2018

Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways.

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31 October 2018

Demonstration of transthyretin mRNA in the brain and other extrahepatic tissues in the rat.

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Thyroxine binding to transthyretin Met 119. Comparative studies of different heterozygotic carriers and structural analysis

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based on heuristic

inferred from PubMed ID database lookup

Interaction of transthyretin with amyloid beta-protein: binding and inhibition of amyloid formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18682830

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nucleation of calcium oxalate crystals by albumin: involvement in the prevention of stone formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18682830

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1371/JOURNAL.PONE.0002899

1 reference

Europe PubMed Central

26 July 2017

2008PLoSO...3.2899C

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1 reference

Europe PubMed Central

26 July 2017

1 reference

Europe PubMed Central

26 July 2017

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