Sequestering of the prehairpin intermediate of gp41 by peptide N36Mut(e,g) potentiates the human immunodeficiency virus type 1 neutralizing activity of monoclonal antibodies directed against the N-terminal helical repeat of gp41 (Q33356323)

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English	Sequestering of the prehairpin intermediate of gp41 by peptide N36Mut(e,g) potentiates the human immunodeficiency virus type 1 neutralizing activity of monoclonal antibodies directed against the N-terminal helical repeat of gp41	scientific article

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scholarly article

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11 January 2020

Sequestering of the prehairpin intermediate of gp41 by peptide N36Mut(e,g) potentiates the human immunodeficiency virus type 1 neutralizing activity of monoclonal antibodies directed against the N-terminal helical repeat of gp41 (English)

1 reference

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11 January 2020

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based on heuristic

inferred from title

monoclonal antibody

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based on heuristic

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G. Marius Clore

3

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11 January 2020

author name string

Elena Gustchina

1

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11 January 2020

Carole A Bewley

2

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publication date

30 July 2008

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11 January 2020

Journal of Virology

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11 January 2020

82

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11 January 2020

10032-10041

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11 January 2020

Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics.

1 reference

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HIV-1 envelope glycoprotein-mediated fusion and pathogenesis: implications for therapy and vaccine development

1 reference

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Assessment of antibody responses against gp41 in HIV-1-infected patients using soluble gp41 fusion proteins and peptides derived from M group consensus envelope

1 reference

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A monoclonal Fab derived from a human nonimmune phage library reveals a new epitope on gp41 and neutralizes diverse human immunodeficiency virus type 1 strains.

1 reference

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1 reference

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Synergistic inhibition of HIV-1 envelope-mediated membrane fusion by inhibitors targeting the N and C-terminal heptad repeats of gp41.

1 reference

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Membrane-anchored inhibitory peptides capture human immunodeficiency virus type 1 gp41 conformations that engage the target membrane prior to fusion

1 reference

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Characterization of antibody responses elicited by human immunodeficiency virus type 1 primary isolate trimeric and monomeric envelope glycoproteins in selected adjuvants

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Characterization and HIV-1 fusion inhibitory properties of monoclonal Fabs obtained from a human non-immune phage library selected against diverse epitopes of the ectodomain of HIV-1 gp41.

1 reference

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A human monoclonal antibody neutralizes diverse HIV-1 isolates by binding a critical gp41 epitope

1 reference

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Conformational changes in HIV-1 gp41 in the course of HIV-1 envelope glycoprotein-mediated fusion and inactivation.

1 reference

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Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodies

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Recommendations for the design and use of standard virus panels to assess neutralizing antibody responses elicited by candidate human immunodeficiency virus type 1 vaccines

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14 July 2018

HIV-1 gp41 as a target for viral entry inhibition

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14 July 2018

HIV-1 gp41: mediator of fusion and target for inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2566276

14 July 2018

Covalent trimers of the internal N-terminal trimeric coiled-coil of gp41 and antibodies directed against them are potent inhibitors of HIV envelope-mediated cell fusion.

1 reference

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Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics

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14 July 2018

Dissection of human immunodeficiency virus type 1 entry with neutralizing antibodies to gp41 fusion intermediates

1 reference

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14 July 2018

A potent cross-clade neutralizing human monoclonal antibody against a novel epitope on gp41 of human immunodeficiency virus type 1.

1 reference

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14 July 2018

Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41.

1 reference

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14 July 2018

Design of potent inhibitors of HIV-1 entry from the gp41 N-peptide region

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Design and properties of N(CCG)-gp41, a chimeric gp41 molecule with nanomolar HIV fusion inhibitory activity

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Mechanisms of viral membrane fusion and its inhibition

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14 July 2018

Protein design of an HIV-1 entry inhibitor

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14 July 2018

Evidence that the transition of HIV-1 gp41 into a six-helix bundle, not the bundle configuration, induces membrane fusion

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Human immunodeficiency virus type 1 spinoculation enhances infection through virus binding

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Sequential CD4-coreceptor interactions in human immunodeficiency virus type 1 Env function: soluble CD4 activates Env for coreceptor-dependent fusion and reveals blocking activities of antibodies against cryptic conserved epitopes on gp120.

1 reference

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Inhibiting HIV-1 entry: discovery of D-peptide inhibitors that target the gp41 coiled-coil pocket

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Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease

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Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug target

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14 July 2018

A conformation-specific monoclonal antibody reacting with fusion-active gp41 from the human immunodeficiency virus type 1 envelope glycoprotein.

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14 July 2018

Three-dimensional solution structure of the 44 kDa ectodomain of SIV gp41

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HIV entry and its inhibition

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14 July 2018

Capture of an early fusion-active conformation of HIV-1 gp41

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Atomic structure of a thermostable subdomain of HIV-1 gp41

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14 July 2018

Atomic structure of the ectodomain from HIV-1 gp41

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14 July 2018

Core structure of gp41 from the HIV envelope glycoprotein

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14 July 2018

Increased envelope spike density and stability are not required for the neutralization resistance of primary human immunodeficiency viruses

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14 July 2018

Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1

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HIV-1 inhibition by a peptide

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14 July 2018

Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infection

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A broadly neutralizing human monoclonal antibody against gp41 of human immunodeficiency virus type 1.

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14 July 2018

Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates.

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14 July 2018

A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1

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14 July 2018

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

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14 July 2018

Dissociation of gp120 from HIV-1 virions induced by soluble CD4.

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14 July 2018

Structural basis for HIV-1 neutralization by a gp41 fusion intermediate-directed antibody.

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31 October 2018

Kinetic dependence to HIV-1 entry inhibition

1 reference

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31 October 2018

Design of a novel peptide inhibitor of HIV fusion that disrupts the internal trimeric coiled-coil of gp41.

1 reference

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31 October 2018

A trimeric structural domain of the HIV-1 transmembrane glycoprotein.

1 reference

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31 October 2018

Generalized Equations for the Analysis of Inhibitions of Michaelis-Menten and Higher-Order Kinetic Systems with Two or More Mutually Exclusive and Nonexclusive Inhibitors

1 reference

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31 October 2018

Steric accessibility of the HIV-1 gp41 N-trimer region

1 reference

https://pubmed.ncbi.nlm.nih.gov/18667502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exposure of the membrane-proximal external region of HIV-1 gp41 in the course of HIV-1 envelope glycoprotein-mediated fusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/18667502

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/JVI.01050-08

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18667502%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18667502%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18667502%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

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