Structures of human proteinase 3 and neutrophil elastase--so similar yet so different (Q33348995)

26 July 2017

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title

Structures of human proteinase 3 and neutrophil elastase--so similar yet so different (English)

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26 July 2017

Nathalie Reuter

5

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Véronique Witko-Sarsat

series ordinal

4

object named as

Véronique Witko-Sarsat

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26 July 2017

Eric Hajjar

1

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26 July 2017

Torben Broemstrup

series ordinal

2

1 reference

26 July 2017

Chahrazade Kantari

series ordinal

3

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26 July 2017

language of work or name

English

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publication date

1 May 2010

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26 July 2017

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26 July 2017

277

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26 July 2017

10

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26 July 2017

2238-2254

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Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells

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Azurocidin and a homologous serine protease from neutrophils. Differential antimicrobial and proteolytic properties

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Neutrophils and immunity: challenges and opportunities

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Degradation of outer membrane protein A in Escherichia coli killing by neutrophil elastase

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Killing activity of neutrophils is mediated through activation of proteases by K+ flux

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Neutrophil serine proteases: potential key regulators of cell signalling during inflammation

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Neutrophil serine proteases: specific regulators of inflammation

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Neutrophils and B lymphocytes in ANCA-associated vasculitis

21 January 2018

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Inspection of the binding sites of proteinase3 for the design of a highly specific substrate

21 January 2018

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Differences in the substrate binding sites of murine and human proteinase 3 and neutrophil elastase

21 January 2018

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Influence of Charge Distribution at the Active Site Surface on the Substrate Specificity of Human Neutrophil Protease 3 and Elastase

21 January 2018

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Computational prediction of the binding site of proteinase 3 to the plasma membrane

21 January 2018

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Structural characterization of mouse neutrophil serine proteases and identification of their substrate specificities: relevance to mouse models of human inflammatory diseases

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On the size of the active site in proteases. I. Papain

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Primary structure of human neutrophil elastase

21 January 2018

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Molecular cloning of complementary DNA for human medullasin: an inflammatory serine protease in bone marrow cells

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Nucleotide sequence of human bone marrow serine protease (medullasin) gene

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Wegener's autoantigen decoded

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Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils

21 January 2018

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Biosynthesis and processing of proteinase 3 in U937 cells. Processing pathways are distinct from those of cathepsin G.

21 January 2018

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Processing and targeting of granule proteins in human neutrophils

21 January 2018

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Inhibition of human neutrophil elastase. 4. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of P2-modified, orally active peptidyl pentafluoroethyl ketones

21 January 2018

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Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151)

21 January 2018

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Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution

21 January 2018

1 reference

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The refined 2.3 A crystal structure of human leukocyte elastase in a complex with a valine chloromethyl ketone inhibitor

21 January 2018

1 reference

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X-ray Snapshot of the Mechanism of Inactivation of Human Neutrophil Elastase by 1,2,5-Thiadiazolidin-3-one 1,1-Dioxide Derivatives †

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07659.X

Complex of human neutrophil elastase with 1/2SLPI

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07659.X

The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies

21 January 2018

1 reference

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Multiple protein sequence alignment from tertiary structure comparison: assignment of global and residue confidence levels

21 January 2018

1 reference

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Functional significance of Asn-linked glycosylation of proteinase 3 for enzymatic activity, processing, targeting, and recognition by anti-neutrophil cytoplasmic antibodies

21 January 2018

1 reference

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The 2.2-A crystal structure of human pro-granzyme K reveals a rigid zymogen with unusual features

21 January 2018

1 reference

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Challenges in pKa predictions for proteins: the case of Asp213 in human proteinase 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07659.X

Electrostatic interactions drive membrane association of the human immunodeficiency virus type 1 Gag MA domain

21 January 2018

1 reference

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Membrane binding of peptides containing both basic and aromatic residues. Experimental studies with peptides corresponding to the scaffolding region of caveolin and the effector region of MARCKS.

21 January 2018

1 reference

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The role of electrostatics in protein-membrane interactions

21 January 2018

1 reference

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Specificity of porcine pancreatic elastase, human leukocyte elastase and cathepsin G Inhibition with peptide chloromethyl ketones

21 January 2018

1 reference

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Substrate specificity of the elastase and the chymotrypsin-like enzyme of the human granulocyte

21 January 2018

1 reference

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Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II. Bovine chymotrypsin A alpha, and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester s

21 January 2018

1 reference

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Catalysis by human leukocyte elastase: mechanistic insights into specificity requirements.

21 January 2018

1 reference

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Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors

21 January 2018

1 reference

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Compared action of neutrophil proteinase 3 and elastase on model substrates. Favorable effect of S'-P' interactions on proteinase 3 catalysts

21 January 2018

1 reference

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Human neutrophil proteinase 3: mapping of the substrate binding site using peptidyl thiobenzyl esters

21 January 2018

1 reference

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Substrate and inhibitor studies on proteinase 3

21 January 2018

1 reference

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Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates

21 January 2018

1 reference

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Inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamides

21 January 2018

1 reference

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Serine protease mechanism and specificity

21 January 2018

1 reference

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Molecular dynamics simulations

21 January 2018

1 reference

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Molecular dynamics simulations of biomolecules

21 January 2018

1 reference

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Molecular dynamics: survey of methods for simulating the activity of proteins

21 January 2018

1 reference

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Cleavage of p21/WAF1/CIP1 by proteinase 3 modulates differentiation of a monocytic cell line. Molecular analysis of the cleavage site.

21 January 2018

1 reference

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Membrane expression of proteinase 3 is genetically determined

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07659.X

Membrane-bound proteinase 3 and its receptors: relevance for the pathogenesis of Wegener's Granulomatosis

21 January 2018

1 reference

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Interaction of proteinase 3 with its associated partners: implications in the pathogenesis of Wegener's granulomatosis

21 January 2018

1 reference

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Interaction of proteinase 3 with CD11b/CD18 (beta2 integrin) on the cell membrane of human neutrophils

21 January 2018

1 reference

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The presence of membrane Proteinase 3 in neutrophil lipid rafts and its colocalization with FcgammaRIIIb and cytochrome b558.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07659.X

Membrane proteinase 3 and its interactions within microdomains of neutrophil membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07659.X

Proteinase 3 and CD177 are expressed on the plasma membrane of the same subset of neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07659.X

NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils

21 January 2018

1 reference

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Apoptosis-induced proteinase 3 membrane expression is independent from degranulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07659.X

Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07659.X

Catalytic activity and inhibition of wegener antigen proteinase 3 on the cell surface of human polymorphonuclear neutrophils.

21 January 2018

1 reference

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Mechanism of membrane binding of the phospholipase D1 PX domain

21 January 2018

1 reference

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Plasma membrane phosphoinositide organization by protein electrostatics

21 January 2018

1 reference

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Biochemical characterization of rous sarcoma virus MA protein interaction with membranes

21 January 2018

1 reference

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Unique membrane interaction mode of group IIF phospholipase A2

21 January 2018

1 reference

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Modeling a spin-labeled fusion peptide in a membrane: implications for the interpretation of EPR experiments

21 January 2018

1 reference

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Self-induced docking site of a deeply embedded peripheral membrane protein

21 January 2018

1 reference

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Inhibition of proteinase 3 by ANCA and its correlation with disease activity in Wegener's granulomatosis.

21 January 2018

1 reference

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Diversity of PR3-ANCA epitope specificity in Wegener's granulomatosis. Analysis using the biosensor technology

21 January 2018

1 reference

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Autoantibodies to neutrophil cytoplasmic antigens (ANCA) do not bind to polymorphonuclear neutrophils in blood

21 January 2018

1 reference

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Human anti-neutrophil cytoplasm autoantibodies to proteinase 3 (PR3-ANCA) bind to neutrophils

21 January 2018

1 reference

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Epitope mapping of anti-proteinase 3 and anti-myeloperoxidase antibodies

21 January 2018

1 reference

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Antineutrophil cytoplasmic antibodies to proteinase 3 in Wegener's granulomatosis: epitope analysis using synthetic peptides

21 January 2018

1 reference

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Epitope mapping of anti-PR3 antibodies using chimeric human/mouse PR3 recombinant proteins

21 January 2018

1 reference

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Human proteinase 3 (PR3) and its binding molecules: implications for inflammatory and PR3-related autoimmune responses

21 January 2018

1 reference

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B cell epitope specificity in ANCA-associated vasculitis: does it matter?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07659.X

Anti-neutrophil cytoplasmic antibodies (ANCA) from patients with systemic vasculitis recognize restricted epitopes of proteinase 3 involving the catalytic site

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07659.X

Differences between human proteinase 3 and neutrophil elastase and their murine homologues are relevant for murine model experiments

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07659.X

Neutrophil serine proteases fine-tune the inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07659.X

Sequence determinants of function and evolution in serine proteases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07659.X

Cleavage of p21waf1 by proteinase-3, a myeloid-specific serine protease, potentiates cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07659.X

Proteinase-3 induces procaspase-3 activation in the absence of apoptosis: potential role of this compartmentalized activation of membrane-associated procaspase-3 in neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07659.X

A hydrophobic patch on proteinase 3, the target of autoantibodies in Wegener granulomatosis, mediates membrane binding via NB1 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07659.X

Configuration of influenza hemagglutinin fusion peptide monomers and oligomers in membranes

21 January 2018

1 reference

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10.1111/J.1742-4658.2010.07659.X

21 January 2018

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DOI

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26 July 2017

1 reference