ET-743. (Q33342402)

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scientific article

Language	Label	Description	Also known as
English	ET-743.	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

1 reference

Europe PubMed Central

ET-743. (English)

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

3

object named as

Greg L Plosker

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

David P Figgitt

2

object named as

David P Figgitt

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

author name string

Risto S Cvetkovic

1

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

publication date

1 January 2002

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

62

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

1185-92; discussion 1193-4

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

https://scigraph.springernature.com/pub.10.2165/00003495-200262080-00005

0 references

In vitro antitumor activity of the novel marine agent, ecteinascidin-743 (ET-743, NSC-648766) against human tumors explanted from patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ecteinascidin 743 induces protein-linked DNA breaks in human colon carcinoma HCT116 cells and is cytotoxic independently of topoisomerase I expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adriamycin versus epirubicin in advanced soft tissue sarcomas. A randomized phase II/phase III study of the EORTC Soft Tissue and Bone Sarcoma Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomized comparison of doxorubicin and vindesine to doxorubicin for patients with metastatic soft-tissue sarcomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclophosphamide versus ifosfamide: a randomized phase II trial in adult soft-tissue sarcomas. The European Organization for Research and Treatment of Cancer [EORTC], Soft Tissue and Bone Sarcoma Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inefficiency of incisions of ecteinascidin 743-DNA adducts by the UvrABC nuclease and the unique structural feature of the DNA adducts can be used to explain the repair-dependent toxicities of this antitumor agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I and pharmacokinetic study of ecteinascidin 743 administered as a 72-hour continuous intravenous infusion in patients with solid malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical detection of P-glycoprotein: prognostic correlation in soft tissue sarcoma of childhood

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomized comparison of three adriamycin regimens for metastatic soft tissue sarcomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomised phase II trial of pegylated liposomal doxorubicin (DOXIL/CAELYX) versus doxorubicin in the treatment of advanced or metastatic soft tissue sarcoma: a study by the EORTC Soft Tissue and Bone Sarcoma Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid activation of MDR1 gene expression in human metastatic sarcoma after in vivo exposure to doxorubicin

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro schedule-dependency of myelotoxicity and cytotoxicity of Ecteinascidin 743 (ET-743).

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Primary gastrointestinal sarcomas: analysis of prognostic variables

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ecteinascidin-743, a new marine natural product with potent antitumor activity on human ovarian carcinoma xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Search for metabolites of ecteinascidin 743, a novel, marine-derived, anti-cancer agent, in man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics and pharmacodynamics of the novel marine-derived anticancer agent ecteinascidin 743 in a phase I dose-finding study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of P-glycoprotein in high-grade osteosarcomas in relation to clinical outcome

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reporting results of cancer treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unique pattern of ET-743 activity in different cellular systems with defined deficiencies in DNA-repair pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Results of single-agent and combination chemotherapy for advanced soft tissue sarcomas. Implications for decision making in the clinic.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High antitumour activity of ET743 against human tumour xenografts from melanoma, non-small-cell lung and ovarian cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Doxorubicin versus CYVADIC versus doxorubicin plus ifosfamide in first-line treatment of advanced soft tissue sarcomas: a randomized study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomized comparison of doxorubicin alone versus ifosfamide plus doxorubicin or mitomycin, doxorubicin, and cisplatin against advanced soft tissue sarcomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensitivity of soft tissue sarcoma cell lines to chemotherapeutic agents: identification of ecteinascidin-743 as a potent cytotoxic agent.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence-dependent enhancement of cytotoxicity produced by ecteinascidin 743 (ET-743) with doxorubicin or paclitaxel in soft tissue sarcoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12010079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2165/00003495-200262080-00005

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

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