A tale of switched functions: from cyclooxygenase inhibition to M-channel modulation in new diphenylamine derivatives (Q33312365)

25 July 2017

A tale of switched functions: from cyclooxygenase inhibition to M-channel modulation in new diphenylamine derivatives (English)

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25 July 2017

Asher Peretz

1

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25 July 2017

Nurit Degani-Katzav

2

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25 July 2017

Maya Talmon

3

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25 July 2017

Eyal Danieli

4

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25 July 2017

Anna Gopin

5

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25 July 2017

Eti Malka

6

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25 July 2017

Rachel Nachman

7

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25 July 2017

Amiram Raz

8

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25 July 2017

Doron Shabat

9

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25 July 2017

Bernard Attali

10

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25 July 2017

language of work or name

English

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publication date

26 December 2007

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25 July 2017

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25 July 2017

2

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25 July 2017

12

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25 July 2017

e1332

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Creative Commons Attribution 4.0 International

25 July 2017

start time

26 December 2007

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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hERG potassium channels and cardiac arrhythmia

21 June 2018

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Synthesis, in vitro and in vivo antimycobacterial activities of diclofenac acid hydrazones and amides

21 June 2018

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Molecular physiology of cardiac repolarization

21 June 2018

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Selective cyclooxygenase 2 inhibitors and cardiovascular events

21 June 2018

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The role of COX-1 and COX-2 in Alzheimer's disease pathology and the therapeutic potentials of non-steroidal anti-inflammatory drugs.

21 June 2018

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Coxibs and cardiovascular disease

21 June 2018

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A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385

21 June 2018

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Nonsteroidal anti-inflammatory drug use and acute myocardial infarction

21 June 2018

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Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2

21 June 2018

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KCNQ potassium channels: physiology, pathophysiology, and pharmacology

21 June 2018

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Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations

21 June 2018

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Neuronal KCNQ potassium channels: physiology and role in disease.

21 June 2018

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Cyclooxygenases: structural, cellular, and molecular biology

21 June 2018

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Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors

21 June 2018

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Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors

21 June 2018

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Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis

21 June 2018

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21 June 2018

Cyclooxygenases 1 and 2

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21 June 2018

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Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

21 June 2018

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Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2

21 June 2018

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21 June 2018

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The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

21 June 2018

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The effects of replacing ester by amide on the biological properties of compounds related to acetylcholine

21 June 2018

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Differential regulation of cyclooxygenases 1 and 2 by interleukin-1 beta, tumor necrosis factor-alpha, and transforming growth factor-beta 1 in human lung fibroblasts

21 June 2018

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Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties

21 January 2018

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Kv7/KCNQ/M and HCN/h, but not KCa2/SK channels, contribute to the somatic medium after-hyperpolarization and excitability control in CA1 hippocampal pyramidal cells.

21 January 2018

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KCNQ/M channels control spike afterdepolarization and burst generation in hippocampal neurons.

21 January 2018

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Cyclooxygenase-2 plays a suppressive role for induction of apoptosis in isoliquiritigenin-treated mouse colon cancer cells

21 January 2018

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Three mechanisms underlie KCNQ2/3 heteromeric potassium M-channel potentiation.

21 January 2018

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Synthesis and pharmacological evaluation of amide conjugates of NSAIDs with L-cysteine ethyl ester, combining potent antiinflammatory and antioxidant properties with significantly reduced gastrointestinal toxicity

21 January 2018

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Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors

21 January 2018

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Molecular modelling of the differential interaction between several non-steroidal anti-inflammatory drugs and human prostaglandin endoperoxide H synthase-2 (h-PGHS-2).

21 January 2018

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Differential binding mode of diverse cyclooxygenase inhibitors

21 January 2018

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Pre- and postsynaptic activation of M-channels by a novel opener dampens neuronal firing and transmitter release.

21 January 2018

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KCNQ/M currents in sensory neurons: significance for pain therapy.

21 January 2018

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Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine.

31 October 2018

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10.1371/JOURNAL.PONE.0001332

31 October 2018

Identifiers

DOI

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25 July 2017

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25 July 2017

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