Structure-function relationships in the cysteine proteinases actinidin, papain and papaya proteinase omega. Three-dimensional structure of papaya proteinase omega deduced by knowledge-based modelling and active-centre characteristics determined by t (Q33281473)

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English	Structure-function relationships in the cysteine proteinases actinidin, papain and papaya proteinase omega. Three-dimensional structure of papaya proteinase omega deduced by knowledge-based modelling and active-centre characteristics determined by t	scientific article

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scholarly article

1 reference

Europe PubMed Central

7 November 2017

Structure-function relationships in the cysteine proteinases actinidin, papain and papaya proteinase omega. Three-dimensional structure of papaya proteinase omega deduced by knowledge-based modelling and active-centre characteristics determined by t (English)

1 reference

Europe PubMed Central

7 November 2017

2

1 reference

Europe PubMed Central

7 November 2017

author name string

Topham CM

1

1 reference

Europe PubMed Central

7 November 2017

Frazao C

3

1 reference

Europe PubMed Central

7 November 2017

Kowlessur D

4

1 reference

Europe PubMed Central

7 November 2017

Thomas M

6

1 reference

Europe PubMed Central

7 November 2017

Brocklehurst SM

7

1 reference

Europe PubMed Central

7 November 2017

Patel M

8

1 reference

Europe PubMed Central

7 November 2017

Thomas EW

9

1 reference

Europe PubMed Central

7 November 2017

Brocklehurst K

10

1 reference

Europe PubMed Central

7 November 2017

language of work or name

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publication date

1 November 1991

1 reference

Europe PubMed Central

7 November 2017

Biochemical Journal

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Europe PubMed Central

7 November 2017

280 ( Pt 1)

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Europe PubMed Central

7 November 2017

79-92

1 reference

Europe PubMed Central

7 November 2017

Differences in the interaction of the catalytic groups of the active centres of actinidin and papain. Rapid purification of fully active actinidin by covalent chromatography and characterization of its active centre by use of two-protonic-state reac

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1130603

21 June 2018

Structure of papain refined at 1.65 A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1130603

21 June 2018

Chymopapain. Chromatographic purification and immunological characterization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1130603

21 June 2018

Comparative resonance Raman spectroscopic and kinetic studies of acyl-enzymes involving papain, actinidin and papaya peptidase II

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1130603

21 June 2018

Problems of classification of papaya latex proteinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1130603

21 June 2018

Effects of conformational selectivity and of overlapping kinetically influential ionizations on the characteristics of pH-dependent enzyme kinetics. Implications of free-enzyme pKa variability in reactions of papain for its catalytic mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1130603

21 June 2018

Fractionation of proteolytic enzymes of dried papaya latex. Isolation and preliminary characterization of a new proteolytic enzyme

1 reference

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21 June 2018

Covalent chromatography. Preparation of fully active papain from dried papaya latex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1130603

21 June 2018

Fresh non-fruit latex of Carica papaya contains papain, multiple forms of chymopapain A and papaya proteinase omega

1 reference

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21 June 2018

Beta-hairpin families in globular proteins

1 reference

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21 June 2018

Using known substructures in protein model building and crystallography

1 reference

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21 June 2018

Substrate-derived two-protonic-state electrophiles as sensitive kinetic specificity probes for cysteine proteinases. Activation of 2-pyridyl disulphides by hydrogen-bonding

1 reference

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21 June 2018

Knowledge based modelling of homologous proteins, Part II: Rules for the conformations of substituted sidechains

1 reference

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21 June 2018

18th Sir Hans Krebs lecture. Knowledge-based protein modelling and design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1130603

21 June 2018

Supracrystallographic resolution of interactions contributing to enzyme catalysis by use of natural structural variants and reactivity-probe kinetics

1 reference

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Analysis and prediction of the different types of beta-turn in proteins

1 reference

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21 June 2018

The thiol proteinases from the latex of Carica papaya L. II. The primary structure of proteinase omega

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1130603

21 June 2018

Structural and electrostatic differences between actinidin and papain account for differences in activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1130603

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1130603

21 June 2018

Differences in the chemical and catalytic characteristics of two crystallographically 'identical' enzyme catalytic sites. Characterization of actinidin and papain by a combination of pH-dependent substrate catalysis kinetics and reactivity probe stu

1 reference

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21 June 2018

Identification of signalling and non-signalling binding contributions to enzyme reactivity. Alternative combinations of binding interactions provide for change in transition-state geometry in reactions of papain

1 reference

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21 June 2018

The interplay of electrostatic fields and binding interactions determining catalytic-site reactivity in actinidin. A possible origin of differences in the behaviour of actinidin and papain

1 reference

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Purification and characterization of a digestive cysteine proteinase from the American lobster (Homarus americanus).

1 reference

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Affinity purification of the novel cysteine proteinase papaya proteinase IV, and papain from papaya latex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1130603

21 June 2018

The thiol proteinases from the latex of Carica papaya L. III. The primary structure of chymopapain

1 reference

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Conformation of beta-hairpins in protein structures. A systematic classification with applications to modelling by homology, electron density fitting and protein engineering

1 reference

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Kinetic parameters of the acyl-enzyme mechanism and conditions for quasi-equilibrium and for optimal catalytic characteristics

1 reference

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A protein engineering study of the role of aspartate 158 in the catalytic mechanism of papain

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Dependence of the P2-S2 stereochemical selectivity of papain on the nature of the catalytic-site chemistry. Quantification of selectivity in the catalysed hydrolysis of the enantiomeric N-acetylphenylalanylglycine 4-nitroanilides

1 reference

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A re-appraisal of the structural basis of stereochemical recognition in papain. Insensitivity of binding-site-catalytic-site signalling to P2-chirality in a time-dependent inhibition

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A general kinetic equation for multihydronic state reactions and rapid procedures for parameter evaluation.

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Preliminary crystallographic data for protease omega

1 reference

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Binding of chloromethyl ketone substrate analogues to crystalline papain

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https://pubmed.ncbi.nlm.nih.gov/1741760

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https://pubmed.ncbi.nlm.nih.gov/1741760

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https://pubmed.ncbi.nlm.nih.gov/1741760

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https://pubmed.ncbi.nlm.nih.gov/1741760

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https://pubmed.ncbi.nlm.nih.gov/1741760

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The thiol proteinases from the latex of Carica papaya L. IV. Proteolytic specificities of chymopapain and papaya proteinase omega determined by digestion of alpha-globin chains

1 reference

https://pubmed.ncbi.nlm.nih.gov/1741760

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based on heuristic

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The thiol proteinases from the latex of Carica papaya L. I. Fractionation, purification and preliminary characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/1741760

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based on heuristic

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https://pubmed.ncbi.nlm.nih.gov/1741760

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Identifiers

10.1042/BJ2800079

1 reference

Europe PubMed Central

7 November 2017

1 reference

Europe PubMed Central

7 November 2017

1 reference

Europe PubMed Central

7 November 2017

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