Proinsulin is refractory to protein fibrillation: topological protection of a precursor protein from cross-beta assembly (Q33225633)

24 July 2017

Proinsulin is refractory to protein fibrillation: topological protection of a precursor protein from cross-beta assembly (English)

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24 July 2017

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Kun Huang

1

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24 July 2017

Jian Dong

2

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24 July 2017

Nelson B Phillips

3

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24 July 2017

Paul R Carey

4

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24 July 2017

Michael A Weiss

5

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24 July 2017

language of work or name

English

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publication date

20 October 2005

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Journal of Biological Chemistry

24 July 2017

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24 July 2017

280

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24 July 2017

42345-42355

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24 July 2017

51

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The spontaneous reoxidation of reduced beef and rat proinsulins

24 July 2017

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The role of assembly in insulin's biosynthesis

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Intracellular transport of proinsulin in pancreatic beta-cells. Structural maturation probed by disulfide accessibility

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Partially folded intermediates in insulin fibrillation

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Mechanism of insulin fibrillation: the structure of insulin under amyloidogenic conditions resembles a protein-folding intermediate.

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Toward understanding insulin fibrillation

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Effect of environmental factors on the kinetics of insulin fibril formation: elucidation of the molecular mechanism

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The protofilament structure of insulin amyloid fibrils

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A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR

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Constraints on supramolecular structure in amyloid fibrils from two-dimensional solid-state NMR spectroscopy with uniform isotopic labeling.

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Laser Raman spectroscopy and the conformation of insulin and proinsulin

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Formation of insulin amyloid fibrils followed by FTIR simultaneously with CD and electron microscopy.

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Putative disulfide-forming pathway of porcine insulin precursor during its refolding in vitro

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Mechanism of insulin chain combination. Asymmetric roles of A-chain alpha-helices in disulfide pairing

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Application of circular dichroism to study RNA folding transitions

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Effect of glucose on the intracellular pH of pancreatic islet cells

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pH-independent and -dependent cleavage of proinsulin in the same secretory vesicle

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The internal pH and membrane potential of the insulin-secretory granule

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Structural properties of Abeta protofibrils stabilized by a small molecule.

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Comparing protein-ligand interactions in solution and single crystals by Raman spectroscopy

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Laser Raman spectra of native and denatured insulin in the solid state

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Insulin at pH 2: structural analysis of the conditions promoting insulin fibre formation

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Probing the mechanism of insulin fibril formation with insulin mutants

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NMR and photo-CIDNP studies of human proinsulin and prohormone processing intermediates with application to endopeptidase recognition

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Raman spectroscopic characterization of secondary structure in natively unfolded proteins: alpha-synuclein

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Protein misfolding, evolution and disease

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Protein folding and disease: a view from the first Horizon Symposium.

21 January 2018

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The binding of thioflavin-T to amyloid fibrils: localisation and implications

21 January 2018

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Structural origins of the functional divergence of human insulin-like growth factor-I and insulin

21 January 2018

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Crystal structure of human insulin-like growth factor-1: detergent binding inhibits binding protein interactions

21 January 2018

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Oxidative refolding of insulin-like growth factor 1 yields two products of similar thermodynamic stability: a bifurcating protein-folding pathway

21 January 2018

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A protein caught in a kinetic trap: structures and stabilities of insulin disulfide isomers

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Conformational disease

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Conformational constraints for amyloid fibrillation: the importance of being unfolded

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Folding proteins in fatal ways

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Outcome in systemic AL amyloidosis in relation to changes in concentration of circulating free immunoglobulin light chains following chemotherapy

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Structural properties of an amyloid precursor of beta(2)-microglobulin

21 January 2018

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Formation of amyloid fibrils from fully reduced hen egg white lysozyme

21 January 2018

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Conformational prerequisites for alpha-lactalbumin fibrillation

21 January 2018

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Review: model peptides and the physicochemical approach to beta-amyloids

21 January 2018

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Solid state NMR reveals a pH-dependent antiparallel beta-sheet registry in fibrils formed by a beta-amyloid peptide.

21 January 2018

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Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils

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Prions, peptides and protein misfolding

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Perk is essential for translational regulation and cell survival during the unfolded protein response

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Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

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Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse

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Role of zinc in insulin biosynthesis. Some possible zinc-insulin interactions in the pancreatic B-cell

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Cloning of complementary DNAs encoding islet amyloid polypeptide, insulin, and glucagon precursors from a New World rodent, the degu, Octodon degus

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Amino acid sequence from degu islet amyloid-derived insulin shows unique sequence characteristics.

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Complex with a phage display-derived peptide provides insight into the function of insulin-like growth factor I

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Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3

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What beta-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism

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Incomplete processing of proinsulin to insulin accompanied by elevation of Des-31,32 proinsulin intermediates in islets of mice lacking active PC2.

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21 January 2018

Identifiers

DOI

10.1074/JBC.M507110200

1 reference

24 July 2017

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