Drug binding in human P-glycoprotein causes conformational changes in both nucleotide-binding domains. (Q33185124)

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14 December 2019

title

Drug binding in human P-glycoprotein causes conformational changes in both nucleotide-binding domains (English)

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14 December 2019

1

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14 December 2019

author name string

M Claire Bartlett

series ordinal

2

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14 December 2019

David M Clarke

series ordinal

3

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language of work or name

English

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publication date

5 November 2002

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Journal of Biological Chemistry

14 December 2019

published in

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14 December 2019

volume

278

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14 December 2019

issue

3

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14 December 2019

page(s)

1575-1578

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Biochemical, cellular, and pharmacological aspects of the multidrug transporter

14 December 2019

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HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.

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Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs

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Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

21 January 2018

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Membrane topology of a cysteine-less mutant of human P-glycoprotein

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Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescence

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The minimum functional unit of human P-glycoprotein appears to be a monomer.

21 January 2018

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The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.

21 January 2018

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Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance

21 January 2018

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Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

21 January 2018

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Effects of lipids on ATPase activity of purified Chinese hamster P-glycoprotein

21 January 2018

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Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state

21 January 2018

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The "LSGGQ" motif in each nucleotide-binding domain of human P-glycoprotein is adjacent to the opposing walker A sequence

21 January 2018

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Superfolding of the partially unfolded core-glycosylated intermediate of human P-glycoprotein into the mature enzyme is promoted by substrate-induced transmembrane domain interactions.

21 January 2018

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Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

21 January 2018

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Cross-linking of human multidrug resistance P-glycoprotein by the substrate, tris-(2-maleimidoethyl)amine, is altered by ATP hydrolysis. Evidence for rotation of a transmembrane helix.

21 January 2018

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Blockage of drug resistance in vitro by disulfiram, a drug used to treat alcoholism

21 January 2018

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P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site

21 January 2018

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Vanadate trapping of nucleotide at the ATP-binding sites of human multidrug resistance P-glycoprotein exposes different residues to the drug-binding site

21 January 2018

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Characterization of the human multidrug resistance protein containing mutations in the ATP-binding cassette signature region

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Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

21 January 2018

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Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis

21 January 2018

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Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil

21 January 2018

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FRET analysis indicates that the two ATPase active sites of the P-glycoprotein multidrug transporter are closely associated.

21 January 2018

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Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

21 January 2018

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The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

21 January 2018

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ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer

21 January 2018

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Inhibition of Oxidative Cross-linking between Engineered Cysteine Residues at Positions 332 in Predicted Transmembrane Segments (TM) 6 and 975 in Predicted TM12 of Human P-glycoprotein by Drug Substrates

21 January 2018

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Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

21 January 2018

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Identification of Residues within the Drug-binding Domain of the Human Multidrug Resistance P-glycoprotein by Cysteine-scanning Mutagenesis and Reaction with Dibromobimane

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M211307200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12421806%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

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