Isolated limb perfusion for extremity soft-tissue sarcomas, in-transit metastases, and other unresectable tumors: credits, debits, and future perspectives (Q33182076)

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English	Isolated limb perfusion for extremity soft-tissue sarcomas, in-transit metastases, and other unresectable tumors: credits, debits, and future perspectives	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

23 July 2017

1 reference

Europe PubMed Central

Isolated limb perfusion for extremity soft-tissue sarcomas, in-transit metastases, and other unresectable tumors: credits, debits, and future perspectives (English)

1 reference

Europe PubMed Central

PubMed publication ID

23 July 2017

author name string

Eggermont AM

1

1 reference

Europe PubMed Central

PubMed publication ID

23 July 2017

ten Hagen TL

2

1 reference

Europe PubMed Central

PubMed publication ID

23 July 2017

publication date

1 July 2001

1 reference

Europe PubMed Central

PubMed publication ID

23 July 2017

Current Oncology Reports

1 reference

Europe PubMed Central

PubMed publication ID

23 July 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

23 July 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

23 July 2017

359-367

1 reference

Europe PubMed Central

PubMed publication ID

23 July 2017

https://scigraph.springernature.com/pub.10.1007/s11912-001-0090-8

0 references

Sarcomas of the limbs. Results of adjuvant chemotherapy using isolation perfusion.

1 reference

https://api.crossref.org/works/10.1007%2FS11912-001-0090-8

21 January 2018

Synergistic effects of TNF-alpha and melphalan in an isolated limb perfusion model of rat sarcoma: a histopathological, immunohistochemical and electron microscopical study

1 reference

https://api.crossref.org/works/10.1007%2FS11912-001-0090-8

21 January 2018

Reduction of interstitial fluid pressure after TNF-alpha treatment of three human melanoma xenografts

1 reference

https://api.crossref.org/works/10.1007%2FS11912-001-0090-8

21 January 2018

Antitumor effect of recombinant tumor necrosis factor-alpha against murine sarcomas at visceral sites: tumor size influences the response to therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic variables in recurrent limb melanoma treated with hyperthermic antiblastic perfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemotherapy of cancer: regional perfusion utilizing an extracorporeal circuit

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of patients with melanoma of the extremity using hyperthermic isolated limb perfusion with melphalan, tumor necrosis factor, and interferon gamma: results of a tumor necrosis factor dose-escalation study

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A randomized controlled trial of prophylactic isolated cytotoxic perfusion for poor-prognosis primary melanoma of the lower limb.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemotherapy of Sarcomas of the Limbs by Regional Perfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenovirus-mediated interleukin 3 beta gene transfer by isolated limb perfusion inhibits growth of limb sarcoma in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic factors for tumor response and limb recurrence-free interval in patients with advanced melanoma of the limbs treated with regional isolated perfusion with melphalan

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

31P magnetic resonance spectroscopy as predictor of clinical response in human extremity sarcomas treated by single dose TNF-alpha + melphalan isolated limb perfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A retrospective comparative study evaluating the results of mild hyperthermic versus controlled normothermic perfusion for recurrent melanoma of the extremities

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early endothelium activation and polymorphonuclear cell invasion precede specific necrosis of human melanoma and sarcoma treated by intravascular high-dose tumour necrosis factor alpha (rTNF alpha)

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolated limb perfusion with tumour necrosis factor-alpha and melphalan with or without interferon-gamma for the treatment of in-transit melanoma metastases: a multicentre randomized phase II study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of hyperthermic perfusion as a first step in the treatment of soft tissue sarcoma of the extremities

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimization of isolated hyperthermic limb perfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of two methods of treating primary malignant melanomas Clark IV and V, thickness 1.5 mm and greater, localized on the extremities. Wide surgical excision with and without adjuvant regional perfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soft tissue sarcomas of the extremity. Multidisciplinary therapy employing hyperthermic perfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toxic effect of tumor necrosis factor on tumor vasculature in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolated limb perfusion with tumor necrosis factor and melphalan for limb salvage in 186 patients with locally advanced soft tissue extremity sarcomas. The cumulative multicenter European experience

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The efficacy of combined treatment with recombinant human tumor necrosis factor-alpha and 5-fluorouracil is dependent on the development of capillaries in tumor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of primary or relapsing limb cancer by isolation perfusion with high-dose alpha-tumor necrosis factor, gamma-interferon, and melphalan

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperthermic perfusion with chemotherapy for melanoma of the extremities

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prophylactic isolation-perfusion as the primary therapy for invasive malignant melanoma of the limbs

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo anti-tumour activity of recombinant human and murine TNF, alone and in combination with murine IFN-gamma, on a syngeneic murine melanoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the anti-tumor efficacy of systemically administered recombinant tumor necrosis factor against several murine tumors in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recombinant Human Tumor Necrosis Factor Administered as a 24-Hour Intravenous Infusion. A Phase I and Pharmacologic Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Barriers to drug delivery in solid tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Results of regional isolation perfusion with cytostatics in patients with soft tissue tumors of the extremities

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Objective regression of unexcised melanoma in-transit metastases after hyperthermic isolation perfusion of the limbs with melphalan

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complete response of melanoma-in-transit metastasis after isolated limb perfusion with tumor necrosis factor alpha and melphalan without massive tumor necrosis: a clinical and histopathological study of the delayed-type reaction pattern.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A clinical and pharmacokinetic study of isolated limb perfusion with heat and melphalan for melanoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolated limb perfusion with TNF alpha and melphalan in a rat osteosarcoma model: a new anti-tumour approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperthermic limb perfusion for malignant melanoma and soft tissue sarcoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolated limb perfusion with tumour necrosis factor-alpha and melphalan for unresectable bone sarcomas of the lower extremity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of the role of neutrophils on the antitumor effect of TNFalpha in an in vivo isolated limb perfusion model in sarcoma-bearing brown Norway rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective heat sensitivity of cancer cells. Biochemical and clinical studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolated limb perfusion for melanoma: effectiveness and toxicity of cisplatin compared with that of melphalan and other drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolated limb perfusion for malignant melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

VWF release and platelet aggregation in human melanoma after perfusion with TNF alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional hyperthermic perfusion with melphalan after surgery for recurrent malignant melanoma of the extremities. Swedish Melanoma Study Group.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperthermic isolated limb perfusion for malignant melanoma: response and survival.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperthermic isolated limb perfusion with tumor necrosis factor alpha, interferon gamma, and melphalan for locally advanced nonmelanoma skin tumors of the extremities: a multicenter study

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Results of isolated regional perfusion in the treatment of malignant soft tissue tumors of the extremities

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-dose recombinant tumor necrosis factor alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Limb recurrence-free interval and survival in patients with recurrent melanoma of the extremities treated with normothermic isolated perfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prophylactic isolated limb perfusion for localized, high-risk limb melanoma: results of a multicenter randomized phase III trial. European Organization for Research and Treatment of Cancer Malignant Melanoma Cooperative Group Protocol 18832, the Wor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A prospective randomized study of regional extremity perfusion in patients with malignant melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Value of therapeutic hyperthermic limb perfusion in advanced recurrent melanoma of the lower extremity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic leakage during isolated limb perfusion for melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Melphalan uptake, hyperthermic synergism and drug resistance in a human cell culture model for the isolated limb perfusion of melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolated limb perfusion with high-dose tumor necrosis factor-alpha in combination with interferon-gamma and melphalan for nonresectable extremity soft tissue sarcomas: a multicenter trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An endotoxin-induced serum factor that causes necrosis of tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low-dose tumour necrosis factor alpha and melphalan in hyperthermic isolated limb perfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II study on neoadjuvant hyperthermic-antiblastic perfusion with doxorubicin in patients with intermediate or high grade limb sarcomas.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toxicity of hyperthermic isolated limb perfusion with cisplatin for recurrent melanoma of the lower extremity after previous perfusion treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Palliation of regional symptoms of advanced extremity melanoma by isolated limb perfusion with melphalan and high-dose tumor necrosis factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dosimetry in isolation perfusion of the limbs by assessment of perfused tissue volume and grading of toxic tissue reactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic antitumour effect of recombinant human tumour necrosis factor alpha with melphalan in isolated limb perfusion in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improved survival for soft tissue sarcoma of the extremities by regional hyperthermic perfusion, local excision and radiation therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endothelial P-selectin expression is reduced in advanced primary melanoma and melanoma metastasis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soft tissue limb sarcomas: Italian clinical trials with hyperthermic antiblastic perfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic antitumor effects of tumor necrosis factor and gamma-interferon on human colon carcinoma cell lines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TNF-alpha augments intratumoural concentrations of doxorubicin in TNF-alpha-based isolated limb perfusion in rat sarcoma models and enhances anti-tumour effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of melanoma in-transit metastases confined to the limb.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolated limb perfusion for local gene delivery: efficient and targeted adenovirus-mediated gene transfer into soft tissue sarcomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide synthase inhibition results in synergistic anti-tumour activity with melphalan and tumour necrosis factor alpha-based isolated limb perfusions

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A retrospective comparative study evaluating the results of a single-perfusion versus double-perfusion schedule with melphalan in patients with recurrent melanoma of the lower limb

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

To perfuse or not to perfuse? A retrospective comparative study to evaluate the effect of adjuvant isolated regional perfusion in patients with stage I extremity melanoma with a thickness of 1.5 mm or greater

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional chemotherapy for melanoma. A 35-year experience

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prerequisites for effective isolated limb perfusion using tumour necrosis factor alpha and melphalan in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperthermic antiblastic perfusion in the treatment of cancer of the extremities.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toxicity and antitumor activity of interferon gamma alone and in combinations with TNFalpha and melphalan in isolated limb perfusion in the BN175 sarcoma tumor model in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperthermic isolated perfusion with melphalan in the treatment of advanced malignant melanoma of the lower limb

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional therapy of melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional perfusion treatment with melphalan for melanoma in a limb: an evaluation of drug kinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/11389822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11912-001-0090-8

1 reference

Europe PubMed Central

PubMed publication ID

23 July 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

23 July 2017

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