A phase I combination study of olaparib with cisplatin and gemcitabine in adults with solid tumors. (Q33161027)

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24 January 2020

title

A phase I combination study of olaparib with cisplatin and gemcitabine in adults with solid tumors (English)

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Baskar Mannargudi

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Giuseppe Giaccone

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Corey A Carter

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author name string

Arun Rajan

1

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Ronan J Kelly

3

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Martin Gutierrez

4

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Shivaani Kummar

5

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Mary Ann Yancey

7

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Jiuping Ji

8

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Sukyung Woo

10

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Shawn Spencer

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William Douglas Figg

12

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language of work or name

English

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publication date

27 February 2012

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24 January 2020

published in

Clinical Cancer Research

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volume

18

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issue

8

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page(s)

2344-2351

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Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?

24 January 2020

cites work

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12 December 2020

Base excision repair is impaired in mammalian cells lacking Poly(ADP-ribose) polymerase-1.

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12 December 2020

Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor

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12 December 2020

Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survival

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12 December 2020

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12 December 2020

The concept of synthetic lethality in the context of anticancer therapy

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12 December 2020

Promoter hypermethylation of FANCF plays an important role in the occurrence of ovarian cancer through disrupting Fanconi anemia-BRCA pathway

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12 December 2020

Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition

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12 December 2020

Combination therapy of poly (ADP-ribose) polymerase inhibitor 3-aminobenzamide and gemcitabine shows strong antitumor activity in pancreatic cancer cells

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12 December 2020

A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair

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12 December 2020

4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1.

1 reference

12 December 2020

Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors.

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12 December 2020

A phase IB trial of intravenous INO-1001 plus oral temozolomide in subjects with unresectable stage-III or IV melanoma.

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12 December 2020

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

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12 December 2020

ATM polymorphisms and risk of lung cancer among never smokers

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12 December 2020

Iniparib plus chemotherapy in metastatic triple-negative breast cancer

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12 December 2020

PARP and cancer--if it's broke, don't fix it.

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12 December 2020

A phase I study of the safety and tolerability of olaparib (AZD2281, KU0059436) and dacarbazine in patients with advanced solid tumours

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12 December 2020

Potential chemotherapeutic activity of 4-iodo-3-nitrobenzamide. Metabolic reduction to the 3-nitroso derivative and induction of cell death in tumor cells in culture

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12 December 2020

Cisplatin and DNA repair in cancer chemotherapy

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12 December 2020

10.1158/1078-0432.CCR-11-2425

Identifiers

DOI

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PubMed publication ID

22371451

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