MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension (Q32884516)

11 July 2017

MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension (English)

1 reference

SMAD specific E3 ubiquitin protein ligase 1

11 July 2017

1 reference

negative regulation of BMP signaling pathway

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

microRNA

1 reference

inferred from title

arterial hypertension

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27214554%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Nicholas W Morrell

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27214554%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Allan Lawrie

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27214554%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

5

Loredana Ciuclan

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27214554%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

author name string

Nadine D Arnold

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27214554%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Josephine A Pickworth

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27214554%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

James Iremonger

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27214554%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Robert M H Allen

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27214554%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Sabine Guth-Gundel

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27214554%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Mark Southwood

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27214554%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Matthew Thomas

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27214554%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Sheila E Francis

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27214554%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

David J Rowlands

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27214554%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

language of work or name

English

0 references

publication date

23 May 2016

1 reference

Journal of Clinical Investigation

11 July 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27214554%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

volume

126

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27214554%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27214554%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

page(s)

2495-2508

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27214554%20AND%20SRC:MED&resulttype=core&format=json

2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS):

7 June 2020

cites work

1 reference

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Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension.

28 July 2018

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Elafin Reverses Pulmonary Hypertension via Caveolin-1-Dependent Bone Morphogenetic Protein Signaling.

28 July 2018

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Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension.

28 July 2018

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Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation

28 July 2018

1 reference

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MicroRNA in pulmonary vascular disease.

28 July 2018

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Updated treatment algorithm of pulmonary arterial hypertension.

28 July 2018

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Relevant issues in the pathology and pathobiology of pulmonary hypertension

28 July 2018

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28 July 2018

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miR-140 suppresses tumor growth and metastasis of non-small cell lung cancer by targeting insulin-like growth factor 1 receptor

28 July 2018

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FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension.

28 July 2018

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Downregulation of miR-140 promotes cancer stem cell formation in basal-like early stage breast cancer

28 July 2018

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Treatment of HCV infection by targeting microRNA

28 July 2018

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Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation

28 July 2018

1 reference

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MicroRNA-140-5p suppresses tumor growth and metastasis by targeting transforming growth factor β receptor 1 and fibroblast growth factor 9 in hepatocellular carcinoma

28 July 2018

1 reference

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Inhibition of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension

28 July 2018

1 reference

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Estrogen receptor α signaling regulates breast tumor-initiating cells by down-regulating miR-140 which targets the transcription factor SOX2.

28 July 2018

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A Smurf1 tale: function and regulation of an ubiquitin ligase in multiple cellular networks

28 July 2018

1 reference

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An evaluation of long-term survival from time of diagnosis in pulmonary arterial hypertension from the REVEAL Registry

28 July 2018

1 reference

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MINT, the molecular interaction database: 2012 update

28 July 2018

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SMURF1 amplification promotes invasiveness in pancreatic cancer

28 July 2018

1 reference

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MiR-140 is co-expressed with Wwp2-C transcript and activated by Sox9 to target Sp1 in maintaining the chondrocyte proliferation.

28 July 2018

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Paigen diet-fed apolipoprotein E knockout mice develop severe pulmonary hypertension in an interleukin-1-dependent manner

28 July 2018

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Role for miR-204 in human pulmonary arterial hypertension

28 July 2018

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Somatic chromosome abnormalities in the lungs of patients with pulmonary arterial hypertension

28 July 2018

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28 July 2018

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HTqPCR: high-throughput analysis and visualization of quantitative real-time PCR data in R.

28 July 2018

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MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses

28 July 2018

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Inflammation, growth factors, and pulmonary vascular remodeling

28 July 2018

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28 July 2018

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28 July 2018

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Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension.

28 July 2018

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MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis

28 July 2018

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Downregulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension

28 July 2018

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Reversal of experimental pulmonary hypertension by PDGF inhibition

28 July 2018

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Towards a proteome-scale map of the human protein–protein interaction network

28 July 2018

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TRANSFAC: transcriptional regulation, from patterns to profiles

28 July 2018

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Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins

28 July 2018

1 reference

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Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family

28 July 2018

1 reference

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Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene

28 July 2018

1 reference

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A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

28 July 2018

1 reference

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Discordant Regulation of microRNA Between Multiple Experimental Models and Human Pulmonary Hypertension.

28 July 2018

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Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension

31 October 2018

1 reference

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Imatinib mesylate as add-on therapy for pulmonary arterial hypertension: results of the randomized IMPRES study.

31 October 2018

1 reference

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Sildenafil potentiates bone morphogenetic protein signaling in pulmonary arterial smooth muscle cells and in experimental pulmonary hypertension

31 October 2018

1 reference

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Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression.

31 October 2018

1 reference

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MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach

31 October 2018

1 reference

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Developing microRNA therapeutics

31 October 2018

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ASPIRE registry: assessing the Spectrum of Pulmonary hypertension Identified at a REferral centre.

31 October 2018

1 reference

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A novel murine model of severe pulmonary arterial hypertension

31 October 2018

1 reference

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Targeted gene delivery of BMPR2 attenuates pulmonary hypertension.

31 October 2018

1 reference

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Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function

31 October 2018

1 reference

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Smurf1 ubiquitin ligase causes downregulation of BMP receptors and is induced in monocrotaline and hypoxia models of pulmonary arterial hypertension

31 October 2018

1 reference

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Genetics and genomics of pulmonary arterial hypertension

31 October 2018

1 reference

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Mutations in bone morphogenetic protein type II receptor cause dysregulation of Id gene expression in pulmonary artery smooth muscle cells: implications for familial pulmonary arterial hypertension

31 October 2018

1 reference

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Evidence of a role for osteoprotegerin in the pathogenesis of pulmonary arterial hypertension

31 October 2018

1 reference

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Phospho.ELM: a database of phosphorylation sites--update 2008.

31 October 2018

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Bone morphogenetic protein type 2 receptor gene therapy attenuates hypoxic pulmonary hypertension

31 October 2018

1 reference

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Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension.

31 October 2018

1 reference

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Imatinib for the treatment of pulmonary arterial hypertension

31 October 2018

1 reference

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Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension

31 October 2018

1 reference

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Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation

31 October 2018

1 reference

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Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle

31 October 2018

1 reference

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Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4922709

Overexpression of the serine elastase inhibitor elafin protects transgenic mice from hypoxic pulmonary hypertension.

31 October 2018

1 reference

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Dysfunctional Smad Signaling Contributes to Abnormal Smooth Muscle Cell Proliferation in Familial Pulmonary Arterial Hypertension

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4922709

Bisoprolol Delays Progression Towards Right Heart Failure in Experimental Pulmonary Hypertension

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27214554

12 December 2020

inferred from PubMed ID database lookup

Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27214554

12 December 2020

inferred from PubMed ID database lookup

Dysregulated Bone Morphogenetic Protein Signaling in Monocrotaline-Induced Pulmonary Arterial Hypertension

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27214554

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1172/JCI83361

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27214554%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27214554%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference