Effect of tocilizumab on neutrophils in adult patients with rheumatoid arthritis: pooled analysis of data from phase 3 and 4 clinical trials (Q31151183)

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Language	Label	Description	Also known as
English	Effect of tocilizumab on neutrophils in adult patients with rheumatoid arthritis: pooled analysis of data from phase 3 and 4 clinical trials	scientific article

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scholarly article

1 reference

Europe PubMed Central

14 October 2017

10 references

13 March 2019

17 June 2019

30 June 2019

27 September 2019

12 October 2019

18 October 2019

27 November 2019

13 December 2019

22 August 2020

14 November 2020

0 references

Effect of tocilizumab on neutrophils in adult patients with rheumatoid arthritis: pooled analysis of data from phase 3 and 4 clinical trials (English)

1 reference

Europe PubMed Central

14 October 2017

phase III clinical trial

0 references

rheumatoid arthritis

10 references

13 March 2019

17 June 2019

30 June 2019

27 September 2019

12 October 2019

18 October 2019

27 November 2019

13 December 2019

22 August 2020

14 November 2020

monoclonal antibody

1 reference

27 September 2019

1 reference

12 October 2019

hemic and immune systems

1 reference

18 October 2019

1 reference

27 November 2019

1 reference

13 December 2019

1 reference

22 August 2020

disease-modifying antirheumatic drug

1 reference

14 November 2020

1 reference

based on heuristic

inferred from title

Andrea Rubbert-Roth

8

object named as

Andrea Rubbert-Roth

0 references

Ronald van Vollenhoven

9

object named as

Ronald van Vollenhoven

1 reference

Europe PubMed Central

14 October 2017

author name string

Robert J Moots

1

1 reference

Europe PubMed Central

14 October 2017

Anthony Sebba

2

1 reference

Europe PubMed Central

14 October 2017

William Rigby

3

1 reference

Europe PubMed Central

14 October 2017

Andrew Ostor

4

1 reference

Europe PubMed Central

14 October 2017

Benjamin Porter-Brown

5

1 reference

Europe PubMed Central

14 October 2017

Francis Donaldson

6

1 reference

Europe PubMed Central

14 October 2017

Sophie Dimonaco

7

1 reference

Europe PubMed Central

14 October 2017

Andrea Rubbert-Roth

8

1 reference

Europe PubMed Central

14 October 2017

Mark C Genovese

10

1 reference

Europe PubMed Central

14 October 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

24 December 2016

1 reference

Europe PubMed Central

14 October 2017

1 April 2017

10 references

13 March 2019

17 June 2019

30 June 2019

27 September 2019

12 October 2019

18 October 2019

27 November 2019

13 December 2019

22 August 2020

14 November 2020

11 references

Europe PubMed Central

14 October 2017

13 March 2019

17 June 2019

30 June 2019

27 September 2019

12 October 2019

18 October 2019

27 November 2019

13 December 2019

22 August 2020

14 November 2020

56

1 reference

Europe PubMed Central

14 October 2017

4

1 reference

Europe PubMed Central

14 October 2017

541-549

1 reference

Europe PubMed Central

14 October 2017

copyright license

Creative Commons Attribution-NonCommercial 4.0 International

10 references

Europe PubMed Central

13 March 2019

Europe PubMed Central

17 June 2019

Europe PubMed Central

30 June 2019

Europe PubMed Central

27 September 2019

Europe PubMed Central

12 October 2019

Europe PubMed Central

18 October 2019

Europe PubMed Central

27 November 2019

Europe PubMed Central

13 December 2019

Europe PubMed Central

22 August 2020

Europe PubMed Central

14 November 2020

on focus list of Wikimedia project

0 references

Subcutaneous tocilizumab versus placebo in combination with disease-modifying antirheumatic drugs in patients with rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410975

21 June 2018

The multifactorial role of neutrophils in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410975

21 June 2018

A randomised, double-blind, parallel-group study of the safety and efficacy of subcutaneous tocilizumab versus intravenous tocilizumab in combination with traditional disease-modifying antirheumatic drugs in patients with moderate to severe rheumato

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410975

21 June 2018

Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410975

21 June 2018

Longterm safety and efficacy of tocilizumab in patients with rheumatoid arthritis: a cumulative analysis of up to 4.6 years of exposure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410975

21 June 2018

Significance of sex in achieving sustained remission in the consortium of rheumatology researchers of North America cohort of rheumatoid arthritis patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410975

21 June 2018

Integrated safety in tocilizumab clinical trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410975

21 June 2018

The comparative risk of serious infections among rheumatoid arthritis patients starting or switching biological agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410975

21 June 2018

The pro- and anti-inflammatory properties of the cytokine interleukin-6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410975

21 June 2018

Anti-TNF therapy is associated with an increased risk of serious infections in patients with rheumatoid arthritis especially in the first 6 months of treatment: updated results from the British Society for Rheumatology Biologics Register with specia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410975

21 June 2018

Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410975

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410975

21 June 2018

IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410975

21 June 2018

Time-dependent increase in risk of hospitalisation with infection among Swedish RA patients treated with TNF antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410975

21 June 2018

Interleukin-6 and chronic inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410975

21 June 2018

Myelotoxicity from chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410975

21 June 2018

Tocilizumab inhibits signal transduction mediated by both mIL-6R and sIL-6R, but not by the receptors of other members of IL-6 cytokine family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410975

21 June 2018

IL-6 plays an essential role in neutrophilia under inflammation.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEW370

21 January 2018

Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEW370

21 January 2018

Infections in patients with rheumatoid arthritis treated with biologic agents

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEW370

21 January 2018

Effects of IL-6 and IL-6 blockade on neutrophil function in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/28013198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutropenia in patients receiving anti-tumor necrosis factor therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/28013198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of pro-inflammatory cytokines on spontaneous apoptosis in leukocyte sub-sets within a whole blood culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/28013198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/28013198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/28013198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 induces demargination of intravascular neutrophils and shortens their transit in marrow

1 reference

https://pubmed.ncbi.nlm.nih.gov/28013198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of s

1 reference

https://pubmed.ncbi.nlm.nih.gov/28013198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation of spontaneous and immune complex-induced neutrophil apoptosis by proinflammatory cytokines. Role of oxidants, Bax and caspase-3

1 reference

https://pubmed.ncbi.nlm.nih.gov/28013198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/RHEUMATOLOGY/KEW370

1 reference

Europe PubMed Central

14 October 2017

1 reference

Europe PubMed Central

14 October 2017

1 reference

Europe PubMed Central

14 October 2017

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