Uncertainties in biological responses that influence hazard and risk approaches to the regulation of endocrine active substances. (Q31143281)

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27 March 2020

title

Uncertainties in biological responses that influence hazard and risk approaches to the regulation of endocrine active substances (English)

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27 March 2020

2

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Lennart Weltje

7

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8

James R Wheeler

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3

Kristin E Brugger

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Sarah M Kadlec

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27 March 2020

author name string

Joanne L Parrott

1

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L Earl Gray

4

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27 March 2020

Taisen Iguchi

5

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publication date

18 January 2017

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Integrated Environmental Assessment and Management

27 March 2020

published in

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volume

13

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issue

2

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27 March 2020

page(s)

293-301

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Effects of the androgenic growth promoter 17-beta-trenbolone on fecundity and reproductive endocrinology of the fathead minnow

27 March 2020

cites work

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Temporal changes in biological responses and uncertainty in assessing risks of endocrine-disrupting chemicals: insights from intensive time-course studies with fish

21 January 2018

1 reference

Toxicity of dimethoate and fenoxycarb to honey bee brood (Apis mellifera), using a new in vitro standardized feeding method.

21 January 2018

1 reference

Persistence of endocrine disruption in zebrafish (Danio rerio) after discontinued exposure to the androgen 17β-trenbolone.

21 January 2018

1 reference

Reversibility of endocrine disruption in zebrafish (Danio rerio) after discontinued exposure to the estrogen 17α-ethinylestradiol.

21 January 2018

1 reference

Chronic perchlorate exposure causes morphological abnormalities in developing stickleback

21 January 2018

1 reference

Evaluating the effects of endocrine disruptors on endocrine function during development

21 January 2018

1 reference

Potency matters: thresholds govern endocrine activity

21 January 2018

1 reference

Modernizing problem formulation for risk assessment necessitates articulation of mode of action

21 January 2018

1 reference

Lack of a heritable reproductive defect in the offspring of male rainbow trout exposed to the environmental estrogen 17alpha-ethynylestradiol

21 January 2018

1 reference

Exposure of Japanese quail embryos to o,p'-DDT has long-term effects on reproductive behaviors, hematology, and feather morphology

21 January 2018

1 reference

Hormesis: why it is important to toxicology and toxicologists

21 January 2018

1 reference

Current limitations and recommendations to improve testing for the environmental assessment of endocrine active substances.

21 January 2018

1 reference

The between-population genetic architecture of growth, maturation, and plasticity in Atlantic salmon

21 January 2018

1 reference

Use of gene expression, biochemical and metabolite profiles to enhance exposure and effects assessment of the model androgen 17β-trenbolone in fish

21 January 2018

1 reference

Investigations of putative reproductive toxicity of low-dose exposures to flutamide in Wistar rats

21 January 2018

1 reference

Inhibition of rat and human steroidogenesis by triazole antifungals

21 January 2018

1 reference

Latent effects of pesticides and toxic substances on sexual differentiation of rodents

21 January 2018

1 reference

Developmental effects of an environmental antiandrogen: the fungicide vinclozolin alters sex differentiation of the male rat.

21 January 2018

1 reference

A dose-response analysis of the reproductive effects of a single gestational dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male Long Evans Hooded rat offspring

21 January 2018

1 reference

Effects of the hormone mimetic insecticide tebufenozide on Chironomus riparius larvae in two different exposure setups.

21 January 2018

1 reference

Density-dependent processes in the life history of fishes: evidence from laboratory populations of zebrafish Danio rerio

21 January 2018

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Mechanistic basis for estrogenic effects in fathead minnow (Pimephales promelas) following exposure to the androgen 17alpha-methyltestosterone: conversion of 17alpha-methyltestosterone to 17alpha-methylestradiol

21 January 2018

1 reference

In utero exposure to the environmental androgen trenbolone masculinizes female Sprague-Dawley rats

21 January 2018

1 reference

Old wine in new bottles: reaction norms in salmonid fishes

21 January 2018

1 reference

A retrospective analysis of the two-generation study: what is the added value of the second generation?

21 January 2018

1 reference

Avian transgenerational reproductive toxicity test with in ovo exposure.

21 January 2018

1 reference

The "low dose" hypothesis: validity and implications for human risk

21 January 2018

1 reference

Non-monotonic dose-response relationships and endocrine disruptors: a qualitative method of assessment

21 January 2018

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Regulation of iodothyronine deiodinases and sodium iodide symporter mRNA expression by perchlorate in larvae and adult Chinese rare minnow (Gobiocypris rarus).

21 January 2018

1 reference

Population-relevant endpoints in the evaluation of endocrine-active substances (EAS) for ecotoxicological hazard and risk assessment

21 January 2018

1 reference

A review of the effects of azole compounds in fish and their possible involvement in masculinization of wild fish populations

21 January 2018

1 reference

21 January 2018

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17β-Trenbolone exposure programs metabolic dysfunction in larval medaka.

21 January 2018

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Trenbolone causes irreversible masculinization of zebrafish at environmentally relevant concentrations

21 January 2018

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Long-term exposure to environmental concentrations of the pharmaceutical ethynylestradiol causes reproductive failure in fish

21 January 2018

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Comparison of vitellogenin induction, sex ratio, and gonad morphology between zebrafish and Japanese medaka after exposure to 17alpha-ethinylestradiol and 17beta-trenbolone

21 January 2018

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Life-cycle exposure of fathead minnows (Pimephales promelas) to an ethinylestradiol concentration below 1 ng/L reduces egg fertilization success and demasculinizes males

21 January 2018

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Effects of 17alpha-ethinylestradiol in a fathead minnow (Pimephales promelas) gonadal recrudescence assay

21 January 2018

1 reference

Perchlorate disrupts embryonic androgen synthesis and reproductive development in threespine stickleback without changing whole-body levels of thyroid hormone.

21 January 2018

1 reference

Reproductive toxicants have a threshold of adversity

21 January 2018

1 reference

Low-dose effects and nonmonotonic dose-responses of endocrine disrupting chemicals: has the case been made?

21 January 2018

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Linear low-dose extrapolation for noncancer heath effects is the exception, not the rule.

21 January 2018

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On the impact of second generation mating and offspring in multi-generation reproductive toxicity studies on classification and labelling of substances in Europe.

21 January 2018

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Concentration- and time-dependent effects of the synthetic estrogen, 17alpha-ethinylestradiol, on reproductive capabilities of the zebrafish, Danio rerio

21 January 2018

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Sensitivity of different generations and developmental stages in studies on reproductive toxicity.

21 January 2018

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Parental effects of endocrine disrupting compounds in aquatic wildlife: Is there evidence of transgenerational inheritance?

21 January 2018

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No threshold dose for estradiol-induced sex reversal of turtle embryos: how little is too much?

21 January 2018

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Propiconazole inhibits steroidogenesis and reproduction in the fathead minnow (Pimephales promelas).

21 January 2018

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The definition of hormesis and its implications for in vitro to in vivo extrapolation and risk assessment.

21 January 2018

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Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses

21 January 2018

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In utero exposure to environmental estrogens and male reproductive health: a systematic review of biological and epidemiologic evidence

21 January 2018

1 reference

Low-dose in utero effects of xenoestrogens in mice and their relevance to humans: an analytical review of the literature

21 January 2018

1 reference

Exposure to 17alpha-ethynylestradiol impairs reproductive functions of both male and female zebrafish (Danio rerio).

21 January 2018

1 reference

Assessment of 17alpha-ethinylestradiol effects and underlying mechanisms in a continuous, multigeneration exposure of the Chinese rare minnow (Gobiocypris rarus).

21 January 2018

1 reference

Assessing dose-response relationships for endocrine disrupting chemicals (EDCs): a focus on non-monotonicity

21 January 2018

1 reference

Population relevance of toxicant mediated changes in sex ratio in fish: An assessment using an individual-based zebrafish (Danio rerio) model

21 January 2018

1 reference

Effects of the synthetic estrogen 17α-ethinylestradiol on the life-cycle of the fathead minnow (Pimephales promelas)

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/IEAM.1866

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27862884%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

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