The anti-inflammatory effect of A3 adenosine receptor agonists: a novel targeted therapy for rheumatoid arthritis (Q31132502)

29 June 2017

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title

The anti-inflammatory effect of A3 adenosine receptor agonists: a novel targeted therapy for rheumatoid arthritis (English)

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29 June 2017

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6

Pnina Fishman

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29 June 2017

Sara Bar-Yehuda

1

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29 June 2017

Michael H Silverman

2

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29 June 2017

William D Kerns

3

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29 June 2017

Avivit Ochaion

4

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29 June 2017

Shira Cohen

5

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29 June 2017

language of work or name

English

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publication date

1 October 2007

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Expert Opinion on Investigational Drugs

29 June 2017

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29 June 2017

16

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29 June 2017

10

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29 June 2017

1601-1613

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New concepts in the treatment of rheumatoid arthritis

29 June 2017

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How is it best to treat early rheumatoid arthritis patients?

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Cloned adenosine A3 receptors: pharmacological properties, species differences and receptor functions

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Adenosine receptors: new opportunities for future drugs.

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Inflammatory cytokines regulate function and expression of adenosine A(2A) receptors in human monocytic THP-1 cells.

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IB-MECA and cardioprotection

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Activation of adenosine A3 receptors reduces ischemic brain injury in rodents.

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Agonists to the A3 adenosine receptor induce G-CSF production via NF-kappaB activation: a new class of myeloprotective agents

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The A3 adenosine receptor is highly expressed in tumor versus normal cells: potential target for tumor growth inhibition

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Elevated expression of A3 adenosine receptors in human colorectal cancer is reflected in peripheral blood cells

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A3 adenosine receptor activation in melanoma cells: association between receptor fate and tumor growth inhibition

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An agonist to the A3 adenosine receptor inhibits colon carcinoma growth in mice via modulation of GSK-3 beta and NF-kappa B.

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CF101, an agonist to the A3 adenosine receptor, enhances the chemotherapeutic effect of 5-fluorouracil in a colon carcinoma murine model

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A novel adenosine analog, thio-Cl-IB-MECA, induces G0/G1 cell cycle arrest and apoptosis in human promyelocytic leukemia HL-60 cells

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The PI3K-NF-kappaB signal transduction pathway is involved in mediating the anti-inflammatory effect of IB-MECA in adjuvant-induced arthritis

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Suppression of macrophage inflammatory protein (MIP)-1alpha production and collagen-induced arthritis by adenosine receptor agonists

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Adenosine A2A agonists in development for the treatment of inflammation

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A1 adenosine receptor upregulation and activation attenuates neuroinflammation and demyelination in a model of multiple sclerosis.

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The A2B adenosine receptor protects against inflammation and excessive vascular adhesion

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Tachycardia caused by A2A adenosine receptor agonists is mediated by direct sympathoexcitation in awake rats

21 January 2018

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Expression of A3 adenosine receptors in human lymphocytes: up-regulation in T cell activation

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ADOA3R as a therapeutic target in experimental colitis: proof by validated high-density oligonucleotide microarray analysis.

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Effect of gamma-butyrobetaine on fatty liver in juvenile visceral steatosis mice

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Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype

21 January 2018

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Structure-activity relationships of N6-benzyladenosine-5'-uronamides as A3-selective adenosine agonists

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Multiple signaling states of G-protein-coupled receptors

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Akt: versatile mediator of cell survival and beyond

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Necessary role of phosphatidylinositol 3-kinase in transforming growth factor beta-mediated activation of Akt in normal and rheumatoid arthritis synovial fibroblasts

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Akt is an endogenous inhibitor toward tumor necrosis factor-related apoptosis inducing ligand-mediated apoptosis in rheumatoid synovial cells

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NF-kappaB and rheumatic diseases

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Inhibition of transcription factors by anti-inflammatory and anti-rheumatic drugs: can variability in response be overcome?

21 January 2018

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Vasoactive intestinal peptide ameliorates synovial cell functions of collagen-induced arthritis rats by down-regulating NF-kappaB activity.

21 January 2018

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Apoptosis as a therapeutic tool in rheumatoid arthritis

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Inhibition of neutrophil apoptosis by type 1 IFN depends on cross-talk between phosphoinositol 3-kinase, protein kinase C-delta, and NF-kappa B signaling pathways

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Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis

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Involvement of phosphatidylinositol 3-kinase gamma in neutrophil apoptosis

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Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3β, and induction of the mitochondrial-dependent intrinsic caspase pathway

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Mechanisms of immune injury in rheumatoid arthritis: evidence for the involvement of T cells and heat-shock protein

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Arthritis induced by a T-lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycans

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The cellular basis of adjuvant arthritis. II. Characterization of the cells mediating passive transfer

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Methotrexate enhances the anti-inflammatory effect of CF101 via up-regulation of the A3 adenosine receptor expression

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Rheumatoid arthritis. Pathophysiology and implications for therapy

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Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand

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Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

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Interleukin-1beta and tumor necrosis factor-alpha, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells

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Bone loss in inflammatory arthritis: mechanisms and treatment strategies

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The adenosine A3 receptor agonist, N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide, is protective in two murine models of colitis

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Methotrexate in rheumatoid arthritis: an update with focus on mechanisms involved in toxicity

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Leflunomide in rheumatoid arthritis: recommendations through a process of consensus

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The effectiveness and toxicity of cyclosporin A in rheumatoid arthritis: longitudinal analysis of a population-based registry

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10.1517/13543784.16.10.1601

21 January 2018

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DOI

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29 June 2017

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